Randomised, Double-blind, Placebo Controlled Trial Of Lithium Carbonate For The Management Of Human Cannabis Withdrawal
Funder
National Health and Medical Research Council
Funding Amount
$523,509.00
Summary
This project aims to help dependent cannabis users stop using cannabis by exploring the safety and effectiveness of lithium in reducing the severity of withdrawal that occurs on cessation of use. Participants will be admitted to an inpatient drug treatment unit (Sydney or Lismore) for 7 days and will be randomly assigned to receive either lithium or placebo. Participants receiving lithium are expected to have less severe withdrawal and higher rates of abstinence from cannabis at follow-up.
Characterising Neurobiological Abnormalities In Cannabis Use Disorders
Funder
National Health and Medical Research Council
Funding Amount
$731,571.00
Summary
Severe Cannabis Use Disorders cause significant harms to quality of life and outcomes including mental health, cognition, motivation and general well being. We will characterise, for the first time, the neuroadaptations associated with cannabis dependence relative to regular use via advanced imaging techniques and examine links between neural alterations and quality of life. This study will help to identify new treatment targets and develop a new neural model of cannabis addiction.
Healthy, Wealthy And Wise: The Long-term Effectiveness Of An Online Universal Program To Prevent Substance Use And Mental Health Problems Among Australian Youth
Funder
National Health and Medical Research Council
Funding Amount
$1,472,709.00
Summary
The proposed study represents a unique opportunity to build on the NHMRC funded Climate Schools Combined (CSC) study, a world-first trial of a combined, internet-delivered school-based approach to preventing substance use, anxiety and depression. Having successfully implemented this trial and followed these students for 3 years, we propose to extend follow-up of this large trial cohort over the critical transition from secondary school into early adulthood.
Heavy Cannabis Use In Two Remote Aboriginal Communities: Prospects For A Population Based Intervention.
Funder
National Health and Medical Research Council
Funding Amount
$301,814.00
Summary
The proposed study is a combined intervention and summative evaluation with two parallel strands. We proposed to develop, deliver and evaluate an educational instrument targeting the use of cannabis amongst Aboriginal people living in remote communities in the Northern Territory. Additionally we proposed to describe and model harmful behaviours and effects of substance misuse with a focus on cannabis and to explore in some detail Aboriginal cultural knowledge and attitudes towards harm and harmf ....The proposed study is a combined intervention and summative evaluation with two parallel strands. We proposed to develop, deliver and evaluate an educational instrument targeting the use of cannabis amongst Aboriginal people living in remote communities in the Northern Territory. Additionally we proposed to describe and model harmful behaviours and effects of substance misuse with a focus on cannabis and to explore in some detail Aboriginal cultural knowledge and attitudes towards harm and harmful behaviours related to substance misuse using self-reported estimates and life histories.Read moreRead less
What Can We Learn About Cannabis Vaping Through The Internet?
Funder
National Health and Medical Research Council
Funding Amount
$61,192.00
Summary
More research is required to address the growing popularity of vaping as a novel method of delivering cannabis in order to minimise harm to mental health, especially in adolescents. This project will examine: 1) the latest trends in cannabis vaping, 2) cannabis vaping communications using data from online cryptomarkets, videos, and social media platforms. The knowledge generated can inform debate and future policies around cannabis use, which is timely and highly controversial in Australia.
The Pharmacology And Toxicity Of Synthetic Cannabinoids
Funder
National Health and Medical Research Council
Funding Amount
$744,808.00
Summary
Synthetic cannabinoids (SCs) have been recently linked to many deaths and hospitalizations but there is limited data available that addresses these issues. We have identified SCs which display unprecedented cannabinoid receptor function, unusual selectivity, and SCs with high activity at cannabinoid receptors. This project will define the role of CB receptors in the actions of SCs, and provide an evidence-based rationale for treating SC overdoses.
Efficacy Of A 3-month Aerobic Exercise Regime For Restoring 'brain Health' In Heavy Cannabis Users
Funder
National Health and Medical Research Council
Funding Amount
$1,209,221.00
Summary
Over a ten-year period, we, and others have documented the brain and psychological harms associated with regular cannabis use. We have now shown that these harms are not permanent, but can be restored. However, the recovery process takes a long time. This study will build on our extensive work to date and, for the first time, investigate whether a specific form of exercise will cause accelerated and beneficial changes in i) the brain and ii) the daily lives of heavy cannabis users.
Cannabidiol May Protect The Brain Against The Harmful Effects Of Marijuana
Funder
National Health and Medical Research Council
Funding Amount
$974,586.00
Summary
While marijuana holds therapeutic potential, prolonged and heavy use is associated with adverse effects on the brain. However, the key constituents of marijuana (THC and CBD) have been found to have opposing effects on the brain (i.e., harmful vs protective). This project will be the first comprehensive examination of the key question - can CBD protect against marijuana-related brain and psychosocial harms?