Australian Laureate Fellowships - Grant ID: FL160100139
Funder
Australian Research Council
Funding Amount
$2,965,538.00
Summary
Outside-In: Strain stiffening as a key to cell control. Outside-In: Strain stiffening as a key to cell control. This research project aims to unravel the highly complex mechanical behaviour of the extracellular matrix, and develop a whole new class of sophisticated and responsive extracellular matrix (ECM) materials. In any multicellular organism, the ECM provides cells with essential mechanical (such as strain stiffening) and biochemical support. The ECM is also critical for biological processe ....Outside-In: Strain stiffening as a key to cell control. Outside-In: Strain stiffening as a key to cell control. This research project aims to unravel the highly complex mechanical behaviour of the extracellular matrix, and develop a whole new class of sophisticated and responsive extracellular matrix (ECM) materials. In any multicellular organism, the ECM provides cells with essential mechanical (such as strain stiffening) and biochemical support. The ECM is also critical for biological processes inside the cell, including proliferation, differentiation and migration. Exactly how the physical and chemical properties of ECMs on the outside of the cell modify the behaviour of a cell on the inside remains unclear. Outcomes would include a blueprint for synthetic ECMs, pushing the boundaries of materials development in the biological and life sciences.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL230100095
Funder
Australian Research Council
Funding Amount
$3,095,070.00
Summary
Materials Nanotectonics: Designing Conductive Inorganic Porous Materials. This project aims to develop the next generation of conductive porous materials through an integrated approach which combines inorganic synthesis with informatics. Using this approach, transition metals can be combined with nonmetals creating mesoporous materials with precise control of their internal space allowing the correlations between structure, composition, properties, and performance to be revealed. This project is ....Materials Nanotectonics: Designing Conductive Inorganic Porous Materials. This project aims to develop the next generation of conductive porous materials through an integrated approach which combines inorganic synthesis with informatics. Using this approach, transition metals can be combined with nonmetals creating mesoporous materials with precise control of their internal space allowing the correlations between structure, composition, properties, and performance to be revealed. This project is expected to generate new highly efficient electrocatalysts and energy conversion devices based on low-cost and earth-abundant transition metals. The project outcomes will position Australia at the forefront of research and development in advanced materials, smart catalysts, and renewable energy technologies.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL160100089
Funder
Australian Research Council
Funding Amount
$2,600,796.00
Summary
In situ electron microscopy toward new materials and applications. In situ electron microscopy toward new materials and applications. This project aims to develop materials for structural and green energy applications, using spatially-resolved, dynamic in situ transmission electron microscopy to research fundamental mechanical, electrical, thermal, optical, optoelectronic and photovoltaic properties of diverse nanostructures. These techniques measure nanomaterial (one-dimensional nanotubes and n ....In situ electron microscopy toward new materials and applications. In situ electron microscopy toward new materials and applications. This project aims to develop materials for structural and green energy applications, using spatially-resolved, dynamic in situ transmission electron microscopy to research fundamental mechanical, electrical, thermal, optical, optoelectronic and photovoltaic properties of diverse nanostructures. These techniques measure nanomaterial (one-dimensional nanotubes and nanowires and two-dimensional graphene-like nanosheets) response to external stimuli, including mechanical, electrical, optical and thermal stimuli. Anticipated outcomes are new ultralight and superstrong structural composites and ‘green-energy’ nanomaterials, such as solar cells, touch panels, batteries, supercapacitors, field-effect transistors, light sensors and displays.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL110100003
Funder
Australian Research Council
Funding Amount
$1,814,346.00
Summary
New directions, new problems and new data types in statistical science. Statistically challenging problems today involve answering many more questions than we have data. Solving them will elucidate the causes of diseases such as cancer, and provide better security for the community. The project will develop new methods for tackling these challenging problems, taking statistical science in new directions.
Australian Laureate Fellowships - Grant ID: FL140100027
Funder
Australian Research Council
Funding Amount
$2,898,150.00
Summary
Under the hood: single-molecule studies of multi-protein machines. Under the hood: single-molecule studies of multi-protein machines. Living cells are filled with complex protein machines that are responsible for the molecular processes supporting life. This project is aimed towards the development of physical tools that enable the study of these protein complexes at the level of single molecules. This project aims to study the protein machinery responsible for DNA replication, the process of du ....Under the hood: single-molecule studies of multi-protein machines. Under the hood: single-molecule studies of multi-protein machines. Living cells are filled with complex protein machines that are responsible for the molecular processes supporting life. This project is aimed towards the development of physical tools that enable the study of these protein complexes at the level of single molecules. This project aims to study the protein machinery responsible for DNA replication, the process of duplicating genomic information before cell division. By making real-time single-molecule movies of the replication process, this project aims to unravel the molecular mechanisms of this important process and provide the knowledge required to understand disease mechanisms and catalyse drug development.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL140100052
Funder
Australian Research Council
Funding Amount
$2,500,000.00
Summary
Macromolecular design for bio-imaging and targeted delivery. Macromolecular design for bio-imaging and targeted delivery. A thorough understanding of how nanoparticles interact with biological systems is imperative if advances are to be made in using nanotechnology for therapeutic applications. Fundamental aspects of nanoparticle transport, targeting and cell uptake will be investigated. This project aims to design novel nanoparticulate systems for the delivery of both an endogenous signalling ....Macromolecular design for bio-imaging and targeted delivery. Macromolecular design for bio-imaging and targeted delivery. A thorough understanding of how nanoparticles interact with biological systems is imperative if advances are to be made in using nanotechnology for therapeutic applications. Fundamental aspects of nanoparticle transport, targeting and cell uptake will be investigated. This project aims to design novel nanoparticulate systems for the delivery of both an endogenous signalling molecule and genes to cells. The project aims to inform future optimal design criteria for bespoke nanoparticle delivery systems.Read moreRead less