Improving and manipulating the immune adjuvant properties of recombinant fowlpox vectors. Unbalanced immune responses may cause or worsen common and important diseases such as infections, allergies, cancers and autoimmunity. Interleukin-4 (IL-4) is the only immune active product or cytokine that safely skews an aberrant immune response to a healing type of response. Fowlpox viruses (FPV) provide safe and effective human vaccines. Engineering FPV to make both a relevant antigen and a cytokine is ....Improving and manipulating the immune adjuvant properties of recombinant fowlpox vectors. Unbalanced immune responses may cause or worsen common and important diseases such as infections, allergies, cancers and autoimmunity. Interleukin-4 (IL-4) is the only immune active product or cytokine that safely skews an aberrant immune response to a healing type of response. Fowlpox viruses (FPV) provide safe and effective human vaccines. Engineering FPV to make both a relevant antigen and a cytokine is proprietary technology. With our commercial partner and using experimental mice, we will test the concept that FPV making a model antigen and IL-4 initiate and/or maintain beneficial Type 2 responses. A successful outcome will guide clinical FPV-based vaccine development for the treatment of important human and veterinary diseases.Read moreRead less
New technology for the delivery of peptide-based T-cell vaccines for tumour immunotherapy. This project is dedicated to finding simple methods for vaccinating humans and animals against a wide variety of cancers. Should this be achieved millions of Australians will be protected from the devastating consequences of cancer. Consequently there will be great benefits socially, medically and economically.
New stable and specific mimics of T cell epitopes for tumor immunotherapy. This project is dedicated to finding simple methods for vaccinating humans and animals against a wide variety of cancers. Should this be achieved millions of Australians will be protected from the devastating consequences of cancer. Consequently there will be great benefits socially, medically and economically.
Aboriginal and non-Aboriginal sex-offenders in Australia: Assessing risk for practice and policy. A key priority of Australian governments is to improve community safety through reducing the risk of sex offenders re-offending after release from prison. This project will assess the validity of tools used to predict the risk of sexual offender recidivism and identify alternate risk assessment tools for Indigenous and non-Indigenous sex offenders.
Strengthening Australia's national integrity system. Strengthening Australia's national integrity system. This project aims to equip governments and civil society stakeholders with evidence-based options to improve the structure and operations of integrity institutions, by undertaking a second National Integrity System Assessment. Public integrity is vital to social and economic prosperity and the quality of democracy. This project intends to identify new, more effective strategies to prevent co ....Strengthening Australia's national integrity system. Strengthening Australia's national integrity system. This project aims to equip governments and civil society stakeholders with evidence-based options to improve the structure and operations of integrity institutions, by undertaking a second National Integrity System Assessment. Public integrity is vital to social and economic prosperity and the quality of democracy. This project intends to identify new, more effective strategies to prevent corruption and other integrity violations; coordinate the work of integrity institutions; ensure their accountability; and measure the effectiveness of integrity and anti-corruption policy settings. This research is expected to contribute to better evaluation of integrity policies worldwide.Read moreRead less
Development and Assessment of Chimaeric Feline Caliciviruses as Vaccines. Feline caliciviruses are major pathogens of cats worldwide, but current vaccines offer only incomplete protection. This project aims to develop novel recombinant vaccine strains that will generate more cross protective immunity and thus provide greater protection for vaccinated cats.
Optimising illicit dark net marketplace interventions. Optimising illicit dark net marketplace interventions. This project aims to develop and test a series of interventions to disrupt identify theft activities, and design an operational risk framework that will aid law enforcement agencies and organisations to timely and appropriately intervene in cyber space. The buying and selling of identity credentials via dark net forums is a significant and growing problem. This research— based on systems ....Optimising illicit dark net marketplace interventions. Optimising illicit dark net marketplace interventions. This project aims to develop and test a series of interventions to disrupt identify theft activities, and design an operational risk framework that will aid law enforcement agencies and organisations to timely and appropriately intervene in cyber space. The buying and selling of identity credentials via dark net forums is a significant and growing problem. This research— based on systems analyses of dark net forums, and bringing together researchers, practitioners, theories and methods from human factors, sociotechnical systems, criminology, and cyber security—is expected to increase understanding of the dark net and improve ways of disrupting identity theft and trading.Read moreRead less
Building an integrated system for Australian bushfire prevention. Building an integrated system for Australian bushfire prevention. This project aims to develop a comprehensive approach to prevent arson. Bushfires are a serious issue in Australia, made worse by climate change; since most of these fires are started by people, it is important to prevent arson. Building on previous work, this project intends to improve community responses, and build a model to predict risk and improve data sharing. ....Building an integrated system for Australian bushfire prevention. Building an integrated system for Australian bushfire prevention. This project aims to develop a comprehensive approach to prevent arson. Bushfires are a serious issue in Australia, made worse by climate change; since most of these fires are started by people, it is important to prevent arson. Building on previous work, this project intends to improve community responses, and build a model to predict risk and improve data sharing. The intended outcome is an all-risks approach to arson prevention and community engagement. This research should reduce the incidence of arson in Australia, and also be useful overseas.Read moreRead less
Reducing antibiotic usage in pig herds: controlling Lawsonia intracellularis by vaccination, housing and hygiene. Pigs are major consumers of antibiotics in Australia. Many of these antibiotics are fed to pigs to prevent proliferative enteritis (PE). There are increasing public concerns regarding the development and spread of antibiotic-resistant bacteria and the potential impact on human health. The adoption of an effective commercial vaccine to prevent PE will reduce the volume of antibiotics ....Reducing antibiotic usage in pig herds: controlling Lawsonia intracellularis by vaccination, housing and hygiene. Pigs are major consumers of antibiotics in Australia. Many of these antibiotics are fed to pigs to prevent proliferative enteritis (PE). There are increasing public concerns regarding the development and spread of antibiotic-resistant bacteria and the potential impact on human health. The adoption of an effective commercial vaccine to prevent PE will reduce the volume of antibiotics used in the pig industry and hence reduce the risk of antibiotic-resistant bacteria developing.Read moreRead less
Development of an Attenuated Infectious Laryngotracheitis Virus Vaccine. This project will develop novel methods for identification of genes involved in virulence of the important avian pathogen Infectious Laryngotracheitis Virus and produce an attenuated, antigenically marked infectious laryngotracheitis virus vaccine strain by specific disruption and deletion of two or more genes in the virusÕs genome.
Infectious laryngotracheitis is a major disease of chickens throughout the world, but curre ....Development of an Attenuated Infectious Laryngotracheitis Virus Vaccine. This project will develop novel methods for identification of genes involved in virulence of the important avian pathogen Infectious Laryngotracheitis Virus and produce an attenuated, antigenically marked infectious laryngotracheitis virus vaccine strain by specific disruption and deletion of two or more genes in the virusÕs genome.
Infectious laryngotracheitis is a major disease of chickens throughout the world, but current vaccines retain some capacity to cause disease. The development of novel attenuated vaccines will thus enhance control of this important disease of poultry.Read moreRead less