Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100043
Funder
Australian Research Council
Funding Amount
$389,000.00
Summary
Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies. This project aims to undertake fast probe-free biochemical/chemical imaging of heterogeneity within cells and materials surfaces with new infrared and Raman imaging. It will generate new fundamental knowledge on: cell heterogeneity and dynamic processes; technologies for optimising cell printing; understanding toxicity of microplastics; and protocols for measuring materials of technological relevance. Expected outcomes inc ....Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies. This project aims to undertake fast probe-free biochemical/chemical imaging of heterogeneity within cells and materials surfaces with new infrared and Raman imaging. It will generate new fundamental knowledge on: cell heterogeneity and dynamic processes; technologies for optimising cell printing; understanding toxicity of microplastics; and protocols for measuring materials of technological relevance. Expected outcomes include: interdisciplinary collaborations in new protocols for in-vitro drug development; cell printing technologies; environmental impacts of microplastics; and materials design. Expected benefits include innovative approaches to early stage drug design; improved environmental controls and advances in innovative materials.Read moreRead less
How does warming prevent soil nitrogen availability from declining in response to elevated CO2? The sustainable use of the terrestrial environment depends upon maintaining ecosystem productivity which in turn depends upon nutrient availability within the soil. Increasing levels of CO2 in the atmosphere are known to decrease nutrient availability while warming prevents this from happening. The aims of this project are to determine how warming is able to prevent elevated CO2 concentrations from re ....How does warming prevent soil nitrogen availability from declining in response to elevated CO2? The sustainable use of the terrestrial environment depends upon maintaining ecosystem productivity which in turn depends upon nutrient availability within the soil. Increasing levels of CO2 in the atmosphere are known to decrease nutrient availability while warming prevents this from happening. The aims of this project are to determine how warming is able to prevent elevated CO2 concentrations from reducing soil N availability and hence productivity in a native grassland ecosystems. This is important, as it will allow likely problems caused by global climate change to be predicted by increasing the understanding of the underlying mechanisms as well as improving the management of grasslands in an environmentally sustainable way. Read moreRead less
Special Research Initiatives - Grant ID: SR0354740
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
CaGaWaLo: regulation of carbon gain and water loss by woody vegetation. Trees and shrubs are widely perceived as central to solving problems of national and international significance. Seed funding is sought to facilitate establishment of a research network focused on their ability to sequester carbon and transmit water to the atmosphere. The proposed network is broadly based in plant physiology and ecology and contains a strong cross-section of leading international expertise in relevant sub- ....CaGaWaLo: regulation of carbon gain and water loss by woody vegetation. Trees and shrubs are widely perceived as central to solving problems of national and international significance. Seed funding is sought to facilitate establishment of a research network focused on their ability to sequester carbon and transmit water to the atmosphere. The proposed network is broadly based in plant physiology and ecology and contains a strong cross-section of leading international expertise in relevant sub-disciplines. By leveraging the huge pool of international expertise and focusing on a range of scales (from molecular to biosphere scales), this network will yield new ideas and approaches that will produce outputs and outcomes of national significance.Read moreRead less
Lamarckian lizards: novel integration of telomere epigenetics, free radicals and innate antioxidants in condition-dependant sexual signal evolution. In 2009, the Nobel Prize in physiology was awarded Drs. Blackburn, Greider and Szostak for discoveries on telomeres. This project will investigate how telomeres not only cap chromosomes from destruction by free radicals, but also have a key role in life itself, in their influence on ageing, longevity, ornaments and lifetime reproductive success.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100006
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
An adaptable and dedicated linear accelerator for medical radiation research. Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using this highly adaptable linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected.
Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-th ....Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-thalassaemia, understanding the specific aHb-binding factor, AHSP is a goal of national significance. In the long term, manipulation of AHSP function through gene therapy may have a direct role in the treatment of thalassaemia.Read moreRead less
Bio-optical model of Antarctic sea-ice algae photosynthesis. Antarctica contains no permanent human population; however the impact of climate change is being observed. Sea-ice is slowly becoming less thick and covering smaller areas of the Southern Ocean. Algae grow on the underside of this sea-ice which feed krill, which in turn support most of the Antarctic food web. Understanding how changes in sea-ice and snow thickness will change the productivity of Antarctica will have significant implica ....Bio-optical model of Antarctic sea-ice algae photosynthesis. Antarctica contains no permanent human population; however the impact of climate change is being observed. Sea-ice is slowly becoming less thick and covering smaller areas of the Southern Ocean. Algae grow on the underside of this sea-ice which feed krill, which in turn support most of the Antarctic food web. Understanding how changes in sea-ice and snow thickness will change the productivity of Antarctica will have significant implications to our management of this wilderness. Knowledge of how sea-ice algae responds to changes in light can be incorporated in climate change models.Read moreRead less
Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge mic ....Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge microscopy techniques to visualise whether the endogenous astrocyte protein metallothionein can promote regeneration in the injured nervous system of living zebrafish. The successful outcomes of this project will provide significant insight into understanding how the brain responds to injury.Read moreRead less
Uncovering the genetic basis for saxitoxin production in Australian marine and freshwater systems: novel molecular tools for management. In Australia, toxic algal blooms have had a devastating impact on marine and freshwater resources. In collaboration with a biotechnology company, this project will use an innovative method to design a molecular genetic tool to monitor, research and potentially mitigate the effects of saxitoxin production on water supplies and aquaculture industries. In working ....Uncovering the genetic basis for saxitoxin production in Australian marine and freshwater systems: novel molecular tools for management. In Australia, toxic algal blooms have had a devastating impact on marine and freshwater resources. In collaboration with a biotechnology company, this project will use an innovative method to design a molecular genetic tool to monitor, research and potentially mitigate the effects of saxitoxin production on water supplies and aquaculture industries. In working with monitoring authorities throughout Australia, we will produce a specific, sensitive and cost-effective technology that will ultimately be applicable worldwide. Read moreRead less
Special Research Initiatives - Grant ID: SR0354787
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Research Network for Biotechnological and Environmental Applications of Microalgae (BEAM). The network will facilitate inderdisciplinary and collaborative research into the limitations on microalgal growth leading to the development of new, commercial-scale microalgae culture systems, the production of fine chemicals, bioactive compounds and renewable fuels (hydrogen), as well as environmental applications such as monitoring the physiological state of phytoplankton in the environment, CO2 biorem ....Research Network for Biotechnological and Environmental Applications of Microalgae (BEAM). The network will facilitate inderdisciplinary and collaborative research into the limitations on microalgal growth leading to the development of new, commercial-scale microalgae culture systems, the production of fine chemicals, bioactive compounds and renewable fuels (hydrogen), as well as environmental applications such as monitoring the physiological state of phytoplankton in the environment, CO2 bioremediation and algal/bacterial systems for the bioremediation of contaminated soils. This will be achieved by applying research on photosynthetic light utilisation efficiency and carbon fixation, chlorophyll fluorescence, biochemistry of secondary metabolites, molecular biology and photobioreactor design and engineering, informed by an understanding of the ecology of these algae.Read moreRead less