Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying ....Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying regulators of lipid metabolism. The large diversity in humans necessitate sufficient sample sizes to identify true genetic regulators, but to date techniques capturing phenotypic data (lipids) have been largely limited. It is anticipated that this study will identify new regulators of lipid metabolism in humans.Read moreRead less
Skin Microbes and Animal Health: Understanding the Ecological Context. This project aims to understand the fundamental ecological relationships between animal hosts (frogs, geckos) and bacteria on their skin by separating host effects from environmental factors that determine skin microbiome composition. The research is significant because it will generate new knowledge needed to understand how skin microbes function in providing protection against disease. Expected outcomes include the provisio ....Skin Microbes and Animal Health: Understanding the Ecological Context. This project aims to understand the fundamental ecological relationships between animal hosts (frogs, geckos) and bacteria on their skin by separating host effects from environmental factors that determine skin microbiome composition. The research is significant because it will generate new knowledge needed to understand how skin microbes function in providing protection against disease. Expected outcomes include the provision of essential information that will guide future research efforts on the factors that determine a healthy skin microbial community (which is needed before skin diseases can be combated). The research will provide significant benefits, including more targeted conservation efforts to combat wildlife skin diseases.Read moreRead less