Advanced Nanostructured Biointerfaces for Cell Capture. The expected outcomes of this interdisciplinary project, which apply the most recent advances in nanotechnology and biophysics to cancer research, will enhance Australia's capacity in Frontier Technology and build strength in Nanobiotechnology. They will bring competitive advantages to the Australian biotechnology and biomedical community for further developments and applications in the multi-billion dollar field of biodiagnostics. These in ....Advanced Nanostructured Biointerfaces for Cell Capture. The expected outcomes of this interdisciplinary project, which apply the most recent advances in nanotechnology and biophysics to cancer research, will enhance Australia's capacity in Frontier Technology and build strength in Nanobiotechnology. They will bring competitive advantages to the Australian biotechnology and biomedical community for further developments and applications in the multi-billion dollar field of biodiagnostics. These innovative biodiagnostic strategies will potentially achieve a significant step in the direction of the once elusive goal of early detection and improved understanding of cancer.Read moreRead less
Tissue distraction: A novel approach to enhance tissue growth for soft tissue engineering purposes. This project will provide new tissues for the expanding field of regenerative medicine to treat numerous tissue defects and
1.Benefit the health & economic well being of Australian society by rapidly supplying organs and tissues.
2.Benefit the academic community by a multidisciplinary approach, involving several academic Institutions in the fields of surgery, tissue engineering, physiology, morph ....Tissue distraction: A novel approach to enhance tissue growth for soft tissue engineering purposes. This project will provide new tissues for the expanding field of regenerative medicine to treat numerous tissue defects and
1.Benefit the health & economic well being of Australian society by rapidly supplying organs and tissues.
2.Benefit the academic community by a multidisciplinary approach, involving several academic Institutions in the fields of surgery, tissue engineering, physiology, morphology, polymer chemistry & biomolecular engineering that will produce basic scientific data with a practical application. Post-graduate students and staff will train & gain significant knowledge in this area.
3. Benefit industry through new product development and IP. This project advances a platform technology with multiple applications.Read moreRead less
Development and validation of virtual epithelial cancer models using an integrated modelling and experimental three-dimensional approach. The mathematical and experimental modelling of the human prostate and ovary applying quantitative bioengineering concepts will lead to virtual cancer models. This project aims to validate these multi-scale models to delineate biological and pathological avenues in healthy and disease tissue and improve prevention and treatment of prostate and ovarian cancer.
Multivalent drug delivery carrier for the targeted delivery of platinum anticancer agents to hepatocytes. Hepatocellular carcinoma (HCC) is often treated with chemotherapy using cytotoxic drugs. This systemic treatment results in the distribution of the drug throughout the body. Employing a polymer particle as a drug carrier for these drugs ensures a temporal control of the release and therefore supply of the drug within the body. By attaching carbohydrate moieties onto the surface of the polyme ....Multivalent drug delivery carrier for the targeted delivery of platinum anticancer agents to hepatocytes. Hepatocellular carcinoma (HCC) is often treated with chemotherapy using cytotoxic drugs. This systemic treatment results in the distribution of the drug throughout the body. Employing a polymer particle as a drug carrier for these drugs ensures a temporal control of the release and therefore supply of the drug within the body. By attaching carbohydrate moieties onto the surface of the polymer particle the drug carrier can specifically be recognized by cell receptors, thus allowing a targeted delivery of the drug to the desired area in the body. A range of carbohydrate-based drug carriers will be synthesized and tested towards their interaction with hepatocytes to allow optimisation of this drug carrier system.
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Core-shell nanoparticle from polymers with pendant cyclodextrins. A better drug delivery system will be developed for the treatment of cancer with albendazole. These nanoparticles enhance the circulation time in the body, but also facilitate the delivery of the drug to the site of the tumour, which will increase the efficacy of the treatment. The nanoparticles are obtained by processing polymers with pendant cyclodextrin groups, which are a type of complex sugars. Aim of this work is the explora ....Core-shell nanoparticle from polymers with pendant cyclodextrins. A better drug delivery system will be developed for the treatment of cancer with albendazole. These nanoparticles enhance the circulation time in the body, but also facilitate the delivery of the drug to the site of the tumour, which will increase the efficacy of the treatment. The nanoparticles are obtained by processing polymers with pendant cyclodextrin groups, which are a type of complex sugars. Aim of this work is the exploration of synthetic routes to generate nanoparticles. Tailoring the underpinning polymer structure of these nanoparticles will allow the optimisation of the release of albendazole from the drug carrier, thus improving cancer treatment.Read moreRead less
Magnetic Nanoparticles for Biomedical Applications. This project will develop biocompatible magnetic nanoparticles for future generations of therapeutic and diagnostic applications. Applications include the reduction in overall toxicity of chemo- and radio- therapy by magnetic target drug delivery, enhanced ability to detect and diagnose diseases using magnetic binding/sorting techniques and an enhanced ability to repair detached retinas. The development of these products provides the potential ....Magnetic Nanoparticles for Biomedical Applications. This project will develop biocompatible magnetic nanoparticles for future generations of therapeutic and diagnostic applications. Applications include the reduction in overall toxicity of chemo- and radio- therapy by magnetic target drug delivery, enhanced ability to detect and diagnose diseases using magnetic binding/sorting techniques and an enhanced ability to repair detached retinas. The development of these products provides the potential for the development of new commercial opportunities in biotechnology and biomedical science in which Australia has an excellent track record. The project will also enhance Australia's capabilities in both nanotechnologiocal and biotechnological sciences.Read moreRead less
Scalable, high throughput microfluidic platforms for tissue specific biomaterials development and tissue genesis. The co-development of novel biomaterial platforms and new generation production methods for tissue analogues will provide the necessary stimulus for improved and more relevant methods of enhanced repair or regeneration of diseased or damaged tissues. These outcomes will result in faster time-to-market new generation therapeutic products for Australia and the world. These advances wil ....Scalable, high throughput microfluidic platforms for tissue specific biomaterials development and tissue genesis. The co-development of novel biomaterial platforms and new generation production methods for tissue analogues will provide the necessary stimulus for improved and more relevant methods of enhanced repair or regeneration of diseased or damaged tissues. These outcomes will result in faster time-to-market new generation therapeutic products for Australia and the world. These advances will have a significant impact on our healthcare costs and the quality of life for all Australians.Read moreRead less