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I am an immunologist-cell biologist investigating the regulation of human immune responses in health and disease. The overall goal of this work is to improve immunity in individuals with immunodeficiencies, or during vaccination, or to attenuate immune re
The Australia Fellowship will enable Prof Good to pursue the development of vaccines for two major pathogens – malaria and group A streptococcus (GAS). Both research programs are entering exciting phases as we move into Phase I clinical trials. At the same time, the Fellowship will enable us to explore the development of the next generation vaccine candidates for these diseases. Malaria is responsible for approximately 1 million deaths per year, mainly of children under 5 years of age, while dis ....The Australia Fellowship will enable Prof Good to pursue the development of vaccines for two major pathogens – malaria and group A streptococcus (GAS). Both research programs are entering exciting phases as we move into Phase I clinical trials. At the same time, the Fellowship will enable us to explore the development of the next generation vaccine candidates for these diseases. Malaria is responsible for approximately 1 million deaths per year, mainly of children under 5 years of age, while diseases caused by group A streptococcus (such as rheumatic heart disease [RHD] and RHD-related stroke) are responsible for at least 500,000 deaths per year. Australia’s Indigenous population suffer the highest documented rate of RHD in the world. We have strong international support and collaboration for these vaccine research programs and have approached the US FDA for a license to conduct the trial for a GAS vaccine and will soon approach them for a licence to undertake the malaria vaccine trial.Read moreRead less
Prof Carbone’s laboratory specialises in the study of immunity at the body surfaces. These surfaces include skin and mucosal tissues such as respiratory and gastrointestinal tract, all of which are the common points of entry for a variety of infectious agents. He has found that there exist cells at these peripheral sites that are separate from the immune components that one finds in the blood and, more importantly, that provide a profound level of protection during new infection. He now propose ....Prof Carbone’s laboratory specialises in the study of immunity at the body surfaces. These surfaces include skin and mucosal tissues such as respiratory and gastrointestinal tract, all of which are the common points of entry for a variety of infectious agents. He has found that there exist cells at these peripheral sites that are separate from the immune components that one finds in the blood and, more importantly, that provide a profound level of protection during new infection. He now propose to determine how best to induce this type of peripheral immune protection and how one can exploit these mechanisms for the purpose of infection control.Read moreRead less