The Role Of LIM Domain Kinase 1 In The Pathogenesis Of Alzheimer’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$565,531.00
Summary
Alzheimer’s disease is characterized by progressive loss of cognition. Few Australians have remained untouched by the effects of Alzheimer’s disease in their families or social circles. Unfortunately, there is no cure and current therapies are limited to modest symptomatic relief. This project will explore the role of a protein that regulates the structural integrity of brain cells in disease, and test if targeting this protein could prevent disease progression.
Microtubule Stabilisation: Promoting Adaptive Plasticity, Brain Healing And Functional Recovery After Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$507,258.00
Summary
Traumatic brain injury (TBI) continues to be the leading cause of death and disability for individuals under 45 years of age. There are currently no effective pharmacotherapeutics available that are able to prevent or minimise brain damage following TBI. My team will use sophisticated in vivo techniques to fully characterise the brain's response to injury and to test whether microtubule stabilisation via new generation taxol-like drugs improves post-trauma outcomes.