An anti-senescence nanoplatform and its underlying mechanism. The project will bring together complementary expertise and skills by combining biomaterials, cell and molecular biology, and engineering, to develop a novel nano-biomaterial platform for anti-senescence and gain an in-depth understanding of its underlying mechanisms. The underlying mechanisms of senescence remain elusive and bone substitutes with anti-senescence property have not been explored and becoming a growing field of interest ....An anti-senescence nanoplatform and its underlying mechanism. The project will bring together complementary expertise and skills by combining biomaterials, cell and molecular biology, and engineering, to develop a novel nano-biomaterial platform for anti-senescence and gain an in-depth understanding of its underlying mechanisms. The underlying mechanisms of senescence remain elusive and bone substitutes with anti-senescence property have not been explored and becoming a growing field of interest in bone regeneration. The project will develop a well-defined and efficient nanomaterial platform with optimal combination of nano-surface features and chemistry for cell rejuvenation, and it will give unprecedented depth of interdisciplinary understanding of senescence rejuvenation mechanisms.Read moreRead less
Engineering the convergence of telecare and telehealth. This project will design a wrist-worn pendant that represents the convergence of telecare (fall detection and personal alarm pendants) and telehealth (remote management of chronic disease). The system has the potential to be retro-fitted to 100,000s of telecare systems deployed by an industry partner and to herald a new form of low-cost patient monitoring.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100200
Funder
Australian Research Council
Funding Amount
$270,427.00
Summary
AutoStem: a high performance, automated stem cell bioengineering facility. This project aims to establish an automated stem cell bioengineering ("AutoStem") facility that will enable critical insights into the molecular mechanisms that underly the loss in stem cell function and tissue homeostasis as we age. The AutoStem facility expects to lead to the discovery of the key drivers of stem cell ageing and the development of novel technological solutions to maintain tissue function with age. The o ....AutoStem: a high performance, automated stem cell bioengineering facility. This project aims to establish an automated stem cell bioengineering ("AutoStem") facility that will enable critical insights into the molecular mechanisms that underly the loss in stem cell function and tissue homeostasis as we age. The AutoStem facility expects to lead to the discovery of the key drivers of stem cell ageing and the development of novel technological solutions to maintain tissue function with age. The outcomes produced from the AutoStem facility will have significant economic and social benefits in enabling healthy ageing and increased productivity for an ageing Australia.Read moreRead less
The development of flexible, graded plasma surface engineered coatings for superior interfacial performance. The next generation of intraocular lenses, medical devices to treat patients with cataracts, will be developed through application of advanced surface engineering technologies. These superior coated lenses will improve biocompatibility and function, leading to additional benefit for the forecasted 2.7 million Australians with cataracts by 2021.
Modelling and manipulating brain network dynamics across the lifespan. This project aims to integrate advanced computational modelling and state-of-the-art recording techniques to generate new knowledge on the neural basis of ageing. People are said to grow wiser as they grow older, though more likely they will experience cognitive slowing and reduced memory functions that interfere with their daily lives. The anticipated goal of the project is to develop techniques to predict the personalised e ....Modelling and manipulating brain network dynamics across the lifespan. This project aims to integrate advanced computational modelling and state-of-the-art recording techniques to generate new knowledge on the neural basis of ageing. People are said to grow wiser as they grow older, though more likely they will experience cognitive slowing and reduced memory functions that interfere with their daily lives. The anticipated goal of the project is to develop techniques to predict the personalised effects of brain stimulation on the ageing brain. The outcomes of this research could significantly improve understanding of brain ageing, and advance the fields of systems neuroscience, network science, and brain stimulation.Read moreRead less
Efficient learning from multiple brain imaging data sets. Brain imaging data analysis methods have proven to be very effective in the study of brain functions and the identification of brain disorders because they minimise the modelling assumptions on the underlying structure of the problem. Analysis of multiple brain imaging data sets, either of the same modality as in multitask or multisubject data sets or from different modalities as in the case of data fusion, is a challenging problem in bi ....Efficient learning from multiple brain imaging data sets. Brain imaging data analysis methods have proven to be very effective in the study of brain functions and the identification of brain disorders because they minimise the modelling assumptions on the underlying structure of the problem. Analysis of multiple brain imaging data sets, either of the same modality as in multitask or multisubject data sets or from different modalities as in the case of data fusion, is a challenging problem in biomedical image analysis. This project will lead to fundamental contributions as well as techniques that address both problems: extraction of relevant features information from multisubject brain imaging data sets of the same modality or from fusion of brain imaging data sets collected from multimodalities.Read moreRead less
Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principl ....Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principles as macroscopic machines. Comparing the artificial motor with biological motors will provide insight into the workings of natural motors. This project should lead to molecular motors for nanobiotechnology.Read moreRead less
Encoding Interactions and Printability into Hairy Colloidal Biomaterials. Printing mixtures of live cells and biomaterials (or 'BioInks') to make bespoke engineered tissues has the potential to enable personalised platforms for therapeutic discovery and organ replacement. Using a novel high throughput approach to materials synthesis, BioInk design and process optimisation, this project aims to discover new biomaterials and printing nozzles to help realise this potential. It will produce new insi ....Encoding Interactions and Printability into Hairy Colloidal Biomaterials. Printing mixtures of live cells and biomaterials (or 'BioInks') to make bespoke engineered tissues has the potential to enable personalised platforms for therapeutic discovery and organ replacement. Using a novel high throughput approach to materials synthesis, BioInk design and process optimisation, this project aims to discover new biomaterials and printing nozzles to help realise this potential. It will produce new insights in colloid science, cell-laden biomaterials design, and BioInk processing. Structure-property-function guides for colloid-based BioInks and quality-assured bioprinting as outcomes represent significant benefits for researchers and industries alike engaged in biofabrication, cell therapy and biotherapeutics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100715
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Tunable plasmonics in ultra-doped transition metal oxides and chalcogenides. The project is designed to explore new classes of plasmonic materials based on low-dimensional transition metal oxide and chalcogenide nanostructures. These crystals, with stratified structures and high surface affinities to charged particles, present a new frontier in plasmonics by allowing reversible stimuli induced doping and defect embedding. The project plans to focus on achieving tunable plasmonic properties acros ....Tunable plasmonics in ultra-doped transition metal oxides and chalcogenides. The project is designed to explore new classes of plasmonic materials based on low-dimensional transition metal oxide and chalcogenide nanostructures. These crystals, with stratified structures and high surface affinities to charged particles, present a new frontier in plasmonics by allowing reversible stimuli induced doping and defect embedding. The project plans to focus on achieving tunable plasmonic properties across a broad spectrum from ultraviolet to infrared light. Targets are systems with low propagation losses or ultra-sensitivity towards environmental changes. The anticipated outcomes will serve as a base to establish the next generation plasmonic communication and sensing systems with active on-chip controllability, which could be used as the base of future telecommunications, energy harvesting and sensing systems.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100119
Funder
Australian Research Council
Funding Amount
$424,607.00
Summary
Manipulation of non-wetting droplets for cell culture. We have recently discovered an innovative and interdisciplinary approach for manipulating non-wetting droplets called “liquid marbles” as a platform for three-dimensional cell culture. This project aims to elucidate the fundamental physics underpinning the electrostatic handling concept of this platform technology. The project is expected to deliver an inexpensive but sophisticated cell culture platform that is well-suited for high-throughpu ....Manipulation of non-wetting droplets for cell culture. We have recently discovered an innovative and interdisciplinary approach for manipulating non-wetting droplets called “liquid marbles” as a platform for three-dimensional cell culture. This project aims to elucidate the fundamental physics underpinning the electrostatic handling concept of this platform technology. The project is expected to deliver an inexpensive but sophisticated cell culture platform that is well-suited for high-throughput drug screening and preparing cells for implantation therapy. Significant benefits for end users in pharmaceutical industry, life sciences research and hospitals are expected from the project and the application of the developed technology.Read moreRead less