Managing infectious disease through partial wildlife social networks. This project aims to investigate the dynamics of the spread of infectious disease in wildlife, derived from incomplete information about contact networks. Infectious diseases in wildlife are difficult to track and control, because it is not feasible to monitor each individual in a population and know the contact network for a population. The project will create ways to best utilise incomplete observational data of contact netw ....Managing infectious disease through partial wildlife social networks. This project aims to investigate the dynamics of the spread of infectious disease in wildlife, derived from incomplete information about contact networks. Infectious diseases in wildlife are difficult to track and control, because it is not feasible to monitor each individual in a population and know the contact network for a population. The project will create ways to best utilise incomplete observational data of contact networks to develop robust predictions of disease spread and population fate, and to reliably predict the outcomes of management interventions. These robust prediction methods will provide better insights for conservation of Australian wildlife.Read moreRead less
Transitions between modes of sex-determination in a changing world. Sex-determination controls the largest variation within animals—the division into males and females. While the different systems of sex-determination—involving genetic or environmental control—are fairly well understood, transitions between these systems remain enigmatic in evolutionary biology. This project aims to address this gap by revealing the molecular change required to transition between systems, using one of only two k ....Transitions between modes of sex-determination in a changing world. Sex-determination controls the largest variation within animals—the division into males and females. While the different systems of sex-determination—involving genetic or environmental control—are fairly well understood, transitions between these systems remain enigmatic in evolutionary biology. This project aims to address this gap by revealing the molecular change required to transition between systems, using one of only two known lizard species exhibiting both genetic and temperature control of sex. This knowledge will have important implications for species conservation, facilitating predictions of highly biased sex ratios under climate change, plus potential commercial applications for species where production of one sex is favoured.Read moreRead less
Cellular mechanisms that protect against copper-bound beta-amyloid. This project will investigate some of the brain’s own mechanisms for protecting itself against Alzheimer’s disease. Understanding these mechanisms will be important for developing future therapeutic strategies for treating Alzheimer’s disease.
Meta-modelling of ecological, evolutionary and climatic systems dynamics. This project aims to improve forecasts of the response of biodiversity to future climate change and so improve on-ground conservation management. Using dynamic systems modelling, tested against field data from a wide variety of case studies, the project models will integrate a variety of biological and geophysical inputs to produce more realistic forecasts of change.
Fire, air, water and earth: Using fossils to discover the evolution of Australia’s open vegetation. How Australia came to be dominated by open, tough-leaved vegetation is an old but still highly controversial question, especially with recent developments in molecular biology that challenge paradigms established from the fossil record. The project will test this new molecular paradigm with innovative use of characteristics of fossil leaves to identify the timing and drivers of the evolution of Au ....Fire, air, water and earth: Using fossils to discover the evolution of Australia’s open vegetation. How Australia came to be dominated by open, tough-leaved vegetation is an old but still highly controversial question, especially with recent developments in molecular biology that challenge paradigms established from the fossil record. The project will test this new molecular paradigm with innovative use of characteristics of fossil leaves to identify the timing and drivers of the evolution of Australia’s open vegetation. The integration of new and rigorous evidence derived from living and fossil plants will provide the clearest evidence yet for the origins of Australian environments. This has ramifications for understanding plant responses to past and future climate changes.Read moreRead less
Capturing Proteus: 65 million years of ecosystem change revealed through evolution of Proteaceae in Australasia. By assessing past changes in the iconic Australian plant family Proteaceae, this research will show how the Australasian vegetation has responded to 65 million years of profound landscape and climate changes. This knowledge from the past will give important insights into how ecosystems can be expected to change under future climate scenarios.
Mechanisms of acclimation of coralline algae to ocean acidification. This project aims to investigate the biological and ecological mechanisms by which reef-building coralline algae may have survived past ocean acidification and warming events and may acclimate to future changes. Coralline algae play critical roles in coral reef ecology but are sensitive to human-induced ocean acidification. However, the abundant geological record coincident with past acidification events is inconsistent with th ....Mechanisms of acclimation of coralline algae to ocean acidification. This project aims to investigate the biological and ecological mechanisms by which reef-building coralline algae may have survived past ocean acidification and warming events and may acclimate to future changes. Coralline algae play critical roles in coral reef ecology but are sensitive to human-induced ocean acidification. However, the abundant geological record coincident with past acidification events is inconsistent with their sensitivity to high carbon dioxide. Acclimation and adaptation is therefore possible but in ways we do not yet understand. The project expects to provide insights to the ability of key marine organisms to acclimate to rapid environmental change and provide information critical for the conservation of valuable marine systems.Read moreRead less
Using metallothioneins as a model for understanding cellular and biochemical interactions between neurons and astrocytes within the brain. This research will reveal some of the changes that occur in the relationship between neurons and astrocytes as a consequence injury, aging or disease to the human brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or in neurodegenerative diseases. These a ....Using metallothioneins as a model for understanding cellular and biochemical interactions between neurons and astrocytes within the brain. This research will reveal some of the changes that occur in the relationship between neurons and astrocytes as a consequence injury, aging or disease to the human brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or in neurodegenerative diseases. These are significant community issues in both economical and social terms. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest cellular processes associated with aging or disease of the brain, and will provide clues to promoting healthy aging.Read moreRead less
Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to th ....Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or neurodegenerative disease. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest biochemical and cellular processes associated with aging or disease of the brain.Read moreRead less
Improved management of coastal plankton systems by ancient DNA technology. This project aims to assemble comprehensive long term Australian plankton records spanning 50 to 1000 years, by applying ancient DNA technology to dated sediment depth cores. Long-term data for Australian coastal and estuarine waters are sparse, so cannot be used for management of fisheries, tourism or urban development. Long-term records are essential to understand how disruptive algal and jellyfish blooms, introduced sp ....Improved management of coastal plankton systems by ancient DNA technology. This project aims to assemble comprehensive long term Australian plankton records spanning 50 to 1000 years, by applying ancient DNA technology to dated sediment depth cores. Long-term data for Australian coastal and estuarine waters are sparse, so cannot be used for management of fisheries, tourism or urban development. Long-term records are essential to understand how disruptive algal and jellyfish blooms, introduced species and increased human use of coastal resources affect dynamic plankton ecosystems. This project’s findings are expected to explore cyclical patterns, define range expansions and understand and manage how dynamic coastal ecosystems respond to multistressor anthropogenic change. Findings will improve understanding of how dynamic marine environments retain their biodiversity values and critical ecological functions.Read moreRead less