Testosterone Intervention For The Prevention Of Diabetes Mellitus In High Risk Men: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$5,054,654.00
Summary
Type 2 diabetes (T2DM) is increasingly common, costly and deadly. Some men at risk of T2DM have low testosterone (T) levels. Our preliminary data suggests that T treatment may prevent the development of T2DM, and improve cardiovascular and sexual function, body composition and bone density, and mood. This remains to be fully tested in a randomized placebo-controlled trial, and this project will do so in a 2-year study of T treatment compared to placebo in men at risk of T2DM participating in a l ....Type 2 diabetes (T2DM) is increasingly common, costly and deadly. Some men at risk of T2DM have low testosterone (T) levels. Our preliminary data suggests that T treatment may prevent the development of T2DM, and improve cardiovascular and sexual function, body composition and bone density, and mood. This remains to be fully tested in a randomized placebo-controlled trial, and this project will do so in a 2-year study of T treatment compared to placebo in men at risk of T2DM participating in a lifestyle program.Read moreRead less
Coping with temperature extremes: morphological constraints on leaf function in a warmer, drier climate. This project will determine how hydraulic properties of temperate, evergreen leaves affect their capacity to cope with seasonal variation in temperature extremes. The results will enhance mechanistic understanding of temperature tolerance, and inform prediction of vegetation change in response to climate warming and increasing CO2 concentrations.
Fiddling while home burns: climate change and fiddler crabs. Climate change is already affecting many Australian animals, including fiddler crabs. This project will use extensive knowledge of fiddler crab biology to determine whether they can behaviourally compensate for the rapid changes that are occurring by using experiments and observations conducted under natural conditions in the mangroves of Darwin harbour.
The Role Of Innate Inflammatory Responses In Viral Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$782,514.00
Summary
Viruses are known to cause arthritis (HIV, hepatitis viruses, mosquito borne viruses). Symptoms of viral arthritis include joint pain, stiffness, and swelling. The mechanism of disease is poorly understood. We have developed a novel animal model of disease and human cell culture models by which to study disease caused by viral infections. This models provide an excellent opportunity to explore the mechanisms of rheumatic disease in a functioning animal and to explore new treatment regimes.
Detecting stress-induced changes to subcellular copper pools in brain cells. Copper (Cu) plays essential roles in the functioning of brain cells, but the regulation and activity of this metal is poorly understood. This project aims to map sub-cellular Cu pools in brain cells, with particular emphasis on the effects of cellular stresses on these pools. These studies are expected to contribute important new methods for the study of Cu biology, and could provide valuable information about how Cu ho ....Detecting stress-induced changes to subcellular copper pools in brain cells. Copper (Cu) plays essential roles in the functioning of brain cells, but the regulation and activity of this metal is poorly understood. This project aims to map sub-cellular Cu pools in brain cells, with particular emphasis on the effects of cellular stresses on these pools. These studies are expected to contribute important new methods for the study of Cu biology, and could provide valuable information about how Cu homeostasis is maintained or perturbed under various stresses. In the future, this work is expected to form the basis of studies of brain Cu pools in neurodegenerative diseases.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100177
Funder
Australian Research Council
Funding Amount
$290,000.00
Summary
A regional optical dating facility in Australia. This project aims to establish an open access, end-user friendly optical dating facility in Australia. This will address shortcomings in the capacity and geographical coverage of the existing national geochronology infrastructure and enable Australian researchers to reconstruct past records of climate change, human evolution, ecological vulnerabilities, natural and man-made hazards and environmental disturbance over historical to near-million-year ....A regional optical dating facility in Australia. This project aims to establish an open access, end-user friendly optical dating facility in Australia. This will address shortcomings in the capacity and geographical coverage of the existing national geochronology infrastructure and enable Australian researchers to reconstruct past records of climate change, human evolution, ecological vulnerabilities, natural and man-made hazards and environmental disturbance over historical to near-million-year timeframes. This project is expected to increase commercial demand for geoscience services and lead to better understanding of Australia’s natural heritage and its long-term vulnerabilities.Read moreRead less
Locating the Commonweal: Community, Environment and Local Governance Regimes in Reform Era Indonesia. The Indonesian government is currently implementing decentralisation legislation to address increasing regional discontent. In the context of political and economic crisis, these institutional reforms are intended to bring about greater popular participation in the political process and in resource management. This research will study several intersecting dimensions of reform in the local domai ....Locating the Commonweal: Community, Environment and Local Governance Regimes in Reform Era Indonesia. The Indonesian government is currently implementing decentralisation legislation to address increasing regional discontent. In the context of political and economic crisis, these institutional reforms are intended to bring about greater popular participation in the political process and in resource management. This research will study several intersecting dimensions of reform in the local domain: popular participation in decentralised governance; resource access and management by local communities; and the implications of reform for local sustainability and equity. The research will produce a comparative analysis of emerging governance patterns in the Reform Era based on locally grounded case studies spanning the Indonesian archipelago.Read moreRead less
Future Keepers: impacts of climate change on ecosystem function providers. The aim of this project is to predict how key ecosystem service providers may change under resource limitation and thermal stress. The project seeks to assess how common species respond to climatic fluctuations and resource limitations when competing for resources in familiar and novel environments along six biogeographic transects throughout Australia. In combination with hypothesis-driven field, laboratory and transplan ....Future Keepers: impacts of climate change on ecosystem function providers. The aim of this project is to predict how key ecosystem service providers may change under resource limitation and thermal stress. The project seeks to assess how common species respond to climatic fluctuations and resource limitations when competing for resources in familiar and novel environments along six biogeographic transects throughout Australia. In combination with hypothesis-driven field, laboratory and transplant experiments, citizen science will be used to create a longitudinal data set of the constraints put on dominant and functionally important species. The project also seeks to enable more robust forecasting of biological responses to environmental change by integrating both empirical and theoretical capabilities.Read moreRead less
Social relations and social engagement in older adulthood: implications for health, well being and cognition. This project will examine the nature of changes in peoples' social networks that occur with age, and the effects of these changes on health and well being in later life. The project will use information collected from several ongoing Australian studies of ageing, and will have important implications for social policy in Australia.