Professor Stick is a career clinician researcher in Paediatric Respiratory Medicine. He has established worl-leading research teams focused on respiratory diseases in young children such as cystic fibrosis and asthma. He has has developed innovative methods to study early childhood respiratory diseases and has been responsible for training scores of clinicians and scientists in the field. He has received national and international awards in recognition of his achievements.
The Next Generation Of Impact In Cystic Fibrosis - Adolescent Mental Health And Beyond
Funder
National Health and Medical Research Council
Funding Amount
$76,365.00
Summary
My project studies adolescents with cystic fibrosis and explore how mental health issues influence and associate with important health outcomes relating to respiratory health, sleep quality, pain issues, family functioning, financial and social status and ability to manage treatment plans. I will recruit participants from the AREST CF (Australian Respiratory Early Surveillance Team for Cystic Fibrosis) project that studies children with CF from diagnosis.
Dr Reid is a respiratory physician determining the relationships between bacterial pathogen behaviour and the host immune response in Cystic Fibrosis. The aim of his research is to use observations made in the clinical setting to develop novel therapeutics and identification of biomarkers that will be employed to pre-empt and better treat clinical disease with the ultimate aim of improving length and quality of life.
Mucous In Heterogeneous And Progressive Early Cystic Fibrosis Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$347,948.00
Summary
Cystic fibrosis (CF) is the most common genetically acquired, life-shortening chronic illness affecting young Australians today. Individuals with CF have a reduced ability to clear mucous from the airways resulting in respiratory infections and inflammation. This project will quantify the biochemical and biophysical properties of mucous in young children with CF to generate novel insights into the pathogenesis of early disease, biomarkers of disease progression and therapeutic targets.
Identification Of The Mechanisms Of Hepatic Fibrogenesis Aid In The Detection And Prediction Of Clinical Outcomes In Paediatric Cholestatic Liver Disease.
Funder
National Health and Medical Research Council
Funding Amount
$624,429.00
Summary
Biliary Atresia (BA) and Cystic Fibrosis Liver Disease (CFLD) are important causes of childhood cirrhosis. Diagnosis is difficult, treatments problematic, and outcomes suboptimal. In BA, bile duct obstruction in infants rapidly progresses to liver failure. It is the most common indication for liver transplantation in children. CFLD causes significant morbidity/mortality in about 20% of CF children. This proposal investigates the mechanisms of liver fibrosis (scarring) and the role of fibrosis in ....Biliary Atresia (BA) and Cystic Fibrosis Liver Disease (CFLD) are important causes of childhood cirrhosis. Diagnosis is difficult, treatments problematic, and outcomes suboptimal. In BA, bile duct obstruction in infants rapidly progresses to liver failure. It is the most common indication for liver transplantation in children. CFLD causes significant morbidity/mortality in about 20% of CF children. This proposal investigates the mechanisms of liver fibrosis (scarring) and the role of fibrosis in both diagnosis and predicting clinical outcome.Read moreRead less
Early Origins Study Of Cystic Fibrosis-related Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$128,188.00
Summary
Cystic Fibrosis is a genetic condition that causes recurrent lung infections and early death. Some patients also develop diabetes which causes a more rapid decline. Many young children with CF have “pre-diabetes” but guidelines do not recommend screening high glucose in this group. In order to intervene early, this study aims to determine if “pre-diabetes” in very young children with Cystic Fibrosis causes poorer growth, lung function or an increase in bacterial infections to.
A Randomized Controlled Trial Of Effects Of Early Life Exposure To General Anaesthesia On Neurobehavioural Outcomes In Children With Cystic Fibrosis (CF)
Funder
National Health and Medical Research Council
Funding Amount
$587,240.00
Summary
Anaesthesia permits surgeries and other interventional procedures that benefit the health of children to be performed painlessly and non-traumatically. This study will provide critical information about whether the drugs used commonly for general anaesthesia represents a risk to very young children in terms of their neurobehavioural development.
Identifying And Preventing The Epithelial Triggers Of Neutrophilic Inflammation In Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$961,124.00
Summary
We have identified aberrant immune responses to viruses and bacteria as potential triggers of damaging airway inflammation soon after children are diagnosed with cystic fibrosis after newborn screening. We will investigate the mechanisms underlying these responses and develop therapies with the potential to reduce inflammation and prevent lung disease.
Clinical And Psychosocial Changes Over Late Childhood And Adolescence And Early Life Determinants Of Long Term Clinical Outcomes In Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$1,135,570.00
Summary
Cystic fibrosis is the most common life shortening inherited disease in Caucasians. Lung damage starts in infancy and lung function falls most rapidly in adolescence although why and how this happens and early life determinants are not known. This study takes advantage of a previous study that monitored young children from 3 months to 5 years of life and follows them closely through early adolescence to investigate the protective and risk factors for falling lung function.