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Early Life Exposures And Chronic Disease: Mechanisms And Preventative Strategies
Funder
National Health and Medical Research Council
Funding Amount
$851,980.00
Summary
The world is facing an epidemic of chronic disease and adverse environmental exposures in early life are partly responsible. One reason why we have not been able to do more to prevent this is the lack of appropriate methods for measuring environmental exposures during pregnancy and infancy. My research will develop and validate methods for measuring exposures early life and the health consequences of these exposures with the aim of developing preventative interventions
Inflammatory Airway Diseases In Children: Mechanisms Underlying And Preventative Strategies
Funder
National Health and Medical Research Council
Funding Amount
$823,008.00
Summary
Professor Sly’s research concentrates on understanding why some children develop chronic lung disease and on finding ways to prevent this from happening.
Mechanisms Of Hepatic Fibrogenesis In Chronic Liver Disease
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
Despite advances made in understanding the mechanisms of liver injury, chronic liver disease continues to be one of the most rapidly growing causes of death in subjects aged <65 years. This is the result of uncontrolled wound healing and regeneration leading ultimately to cirrhosis and liver cancer. This research will identify and characterise pathways that control the wound healing response to liver injury, involving the processes of inflammation, scarring and restitution of normal liver mas ....Despite advances made in understanding the mechanisms of liver injury, chronic liver disease continues to be one of the most rapidly growing causes of death in subjects aged <65 years. This is the result of uncontrolled wound healing and regeneration leading ultimately to cirrhosis and liver cancer. This research will identify and characterise pathways that control the wound healing response to liver injury, involving the processes of inflammation, scarring and restitution of normal liver mass.Read moreRead less
Iron is essential in the diet but it is also toxic when present in excess, so both iron deficiency and iron overload can have significant clinical consequences. I will investigate the basic mechanisms by which the body acquires iron and how iron can lead to toxicity. The goal of these studies is to provide more effective iron supplements and to improve diagnosis and treatment of iron-related diseases. Iron metabolism in pregnancy, infants and respiratory diseases will be a particular focus.
This fellowship support will allow A/Prof Xiao-Jun DU to pursue his recent pre-clinical research findings on novel therapeutic interventions for cardiovascular diseases. He will particularly focus on new treatment of accumulation of excessive scar tissues (fibrosis) in the heart and large arteries following disease and cardiac inflammation, factors knowing to play pivotal roles in progression of cardiovascular diseases.
Liver Injury And Iron Homeostasis In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
Iron disorders and liver disease are a significant burden on society, affecting many in the prime of their life. Disordered iron metabolism also plays a significant role in many disorders and diseases including cancers, neurodegenerative and iron overload disorders, and anaemia associated with chronic disease. My objective is to understand the molecules and mechanisms involved, and to develop strategies and reagents to diagnose, prevent and treat liver and iron-related disease.
I am a matrix biologist determining the molecular mechanisms and novel therapeutic targets for fibrosis (tissue scarring). In particular, my research, which has a strong translational focus, is involved with elucidating the anti-fibrotic potential of the relaxin peptide-hormones (either alone or as an adjunct therapies to existing/other novel treatments) – as a means of developing therapeutic strategies for the treatment of cardiac and renal fibrosis.
Integrated Basic And Clinical Cardiovascular Research For The Development Of Innovative Approaches To The Treatment Of Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$925,346.00
Summary
Heart failure (HF) is a common cardiovascular problem which causes disabling symptoms and reduces life expectancy. HF is the commonest cause or contributor to hospitalization in people over 65 years. For patients with advanced HF, survival is worse than that for aggresive cancers. At present, for patients with advanced HF and its complications, there are very few treatment options. Over the next 5 years I will conduct a comprehensive series of studies in animal models and in patients to develop ....Heart failure (HF) is a common cardiovascular problem which causes disabling symptoms and reduces life expectancy. HF is the commonest cause or contributor to hospitalization in people over 65 years. For patients with advanced HF, survival is worse than that for aggresive cancers. At present, for patients with advanced HF and its complications, there are very few treatment options. Over the next 5 years I will conduct a comprehensive series of studies in animal models and in patients to develop new treatment options.Read moreRead less
Mechanistic And Translational Studies Targeting Kidney Inflammation And Fibrosis.
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
The progression of kidney disease to end-stage renal failure requires support by dialysis or kidney transplantation, leading to reduced quality of life, loss of productivity, and the huge cost of renal replacement therapy in Australia ($1 billion in 2010). This research program focuses on two areas; advancing our understanding of the basic mechanisms of disease pathogenesis, and working with commercial partners to translate my current research effort towards new therapies for kidney disease.
Research Fellowship: Protection Of Myocardial Function In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
Heart failure (HF) is a major cause of death in Australia. A/Prof Rebecca Ritchie heads Heart Failure Pharmacology at Baker IDI. Her research focuses on new drug strategies to maintain heart function in response to diabetes & heart attack, common precursors of HF. Many of the treatments discovered from this work are naturally-occurring antioxidants; enhancing their activity will ultimately reduce progression to HF & death in the >3 million Australians affected by these disorders.