Determining Fundamental Mechanisms Compromised In Kir-linked Disease States
Funder
National Health and Medical Research Council
Funding Amount
$600,040.00
Summary
The human nervous system and organs are reliant on precisely controlled transmission of electrical currents through sodium and potassium channels. Their core functions are compromised when currents fail to switch on and off normally. Faulty potassium channels are implicated in diabetes, epilepsy and heart failure. This project re-examines the mechanisms controlling potassium channels, with a view to scientific and therapeutic discrimination between the different classes present in human cells.
Structural Studies On Cell Signalling Via The LIF Receptor And Gp130
Funder
National Health and Medical Research Council
Funding Amount
$453,943.00
Summary
The cytokines play important roles in the immune system during blood cell development and inflammation, and in nerve growth, bone remodeling, reproduction and heart development. Cell responses are initiated by a cytokine bringing together on the cell surface a receptor complex made up of multiple molecules. This project will investigate the atomic structure of the cell surface macromolecular complex, and hence the underlying mechanism by which cytokine signals are initiated.
A Direct Approach to Crystal Structure Determination - a solution to the phase problem. The purpose of this research is to determine the positions of atoms in crystals and nano-crystals. We have developed a theory that shows how to extract all of the information required to determine atomic positions from such crystals and we have carried through initial successful tests on simple materials. In particular, we have found that crystallographic phase, hitherto not directly measurable, can in fact b ....A Direct Approach to Crystal Structure Determination - a solution to the phase problem. The purpose of this research is to determine the positions of atoms in crystals and nano-crystals. We have developed a theory that shows how to extract all of the information required to determine atomic positions from such crystals and we have carried through initial successful tests on simple materials. In particular, we have found that crystallographic phase, hitherto not directly measurable, can in fact be extracted uniquely from a single electron diffraction pattern. This constitutes a solution to the phase problem in crystallography. It is now our aim to develop this method into a routine technique.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100076
Funder
Australian Research Council
Funding Amount
$155,000.00
Summary
The first Australian high pressure Synchrotron facility for geoscience research. In high-pressure mineral physics and chemistry, mineral properties, stress-strain relationships and processes like partial melting are applied to geophysical research about the deep Earth. This project will provide a large volume, high pressure capability at the Australian Synchrotron which will allow these mineral properties to be measured under conditions which simulate the deep earth.
Discovery Early Career Researcher Award - Grant ID: DE150100770
Funder
Australian Research Council
Funding Amount
$358,536.00
Summary
Solving the mystery of natural carbon mineralisation in Australian lakes. Some lakes, such as the Coorong lakes in South Australia, naturally sequester carbon dioxide in magnesium carbonate minerals. These minerals, which form in association with microorganisms in lake water, represent the safest possible long-term traps for carbon dioxide pollution. This project aims to determine the essential geochemical constraints on formation of magnesium carbonate minerals in the Coorong lakes, which are u ....Solving the mystery of natural carbon mineralisation in Australian lakes. Some lakes, such as the Coorong lakes in South Australia, naturally sequester carbon dioxide in magnesium carbonate minerals. These minerals, which form in association with microorganisms in lake water, represent the safest possible long-term traps for carbon dioxide pollution. This project aims to determine the essential geochemical constraints on formation of magnesium carbonate minerals in the Coorong lakes, which are unique natural laboratories for studying carbon dioxide sequestration. By delivering fundamental understanding of how microbial populations alter water chemistry for carbonate production, this project aims to inform the design of efficient and sustainable technologies for carbon dioxide sequestration that emulate natural processes in lakes.Read moreRead less
Self-zoning in natural uraninite: radiation driven chemical separation. In this project we aim to explore and define the effects of the substitution of lead and rare earths on the crystal chemistry of uranium dioxide (uraninite) and related minerals, towards establishing the oxygen stoichiometry (as a measure of oxygen fugacity) of these materials both in nature and in synthetic materials. This project will use synthetic materials to understand the variability of oxygen stoichiometry, establish ....Self-zoning in natural uraninite: radiation driven chemical separation. In this project we aim to explore and define the effects of the substitution of lead and rare earths on the crystal chemistry of uranium dioxide (uraninite) and related minerals, towards establishing the oxygen stoichiometry (as a measure of oxygen fugacity) of these materials both in nature and in synthetic materials. This project will use synthetic materials to understand the variability of oxygen stoichiometry, establish accurate and precise structures for the oxides, and distinguish both long range and short-range order which is critical to understanding both natural and synthetic U-oxides. This will help to define the geochemical conditions leading to the formation of deposits like Olympic Dam towards potential economic benefit.Read moreRead less
Developing indicator minerals to geochemically fingerprint mineralized Fe oxide Cu-Au systems: a pilot study around the Ernest Henry Cu-Au mine. Fe oxide Cu-Au deposits represent some of the largest accumulations of economically extractable metal in the earth's crust. However, exploration has been largely ineffective over the last decade, and new methods for their delineation are required to deliver a step-change in the efficiency of exploration programs. The development of a mineral indicator s ....Developing indicator minerals to geochemically fingerprint mineralized Fe oxide Cu-Au systems: a pilot study around the Ernest Henry Cu-Au mine. Fe oxide Cu-Au deposits represent some of the largest accumulations of economically extractable metal in the earth's crust. However, exploration has been largely ineffective over the last decade, and new methods for their delineation are required to deliver a step-change in the efficiency of exploration programs. The development of a mineral indicator scheme to fingerprint potential ?ore-forming? systems using state-of-the-art laser ablation ICP-MS analysis may engender new methods and strategies that lead to exploration success. A baseline study around a known deposit provides the best means to characterize indicators- the Ernest Henry Cu-Au deposit provides the ideal candidate.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100103
Funder
Australian Research Council
Funding Amount
$547,000.00
Summary
Australian Virtual Experimental Laboratory: a multimode geoscience facility. Australian virtual experimental laboratory: a multimode geoscience facility:
This project aims to establish seven types of high-pressure equipment to form a multi-node experimental laboratory at four locations across Australia. Experiments conducted at the high pressures and temperatures of the internal Earth form the basis of our knowledge about the physical and chemical processes that drive geological processes such ....Australian Virtual Experimental Laboratory: a multimode geoscience facility. Australian virtual experimental laboratory: a multimode geoscience facility:
This project aims to establish seven types of high-pressure equipment to form a multi-node experimental laboratory at four locations across Australia. Experiments conducted at the high pressures and temperatures of the internal Earth form the basis of our knowledge about the physical and chemical processes that drive geological processes such as plate tectonics, melting to form volcanoes, and the formation and movement of fluids that concentrate precious metals into valuable ore deposits. The new facility may enable major advances in fields such as mantle geodynamics and element transport in fluids, improving our understanding of internal Earth processes and ore deposit formation and location. It also includes portable systems, which can be used in synchrotron applications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989986
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims ....Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims to provide outstanding opportunities for the training of research students, expanding research in the fields of materials, minerals, geological, environmental and forensic science enabling to maintain Australia's lead and competitiveness in cutting edge research and technology. Read moreRead less
A study of high temperature transformation of oil shale - In-situ mineral reactions and structure analysis. In the current energy market, non-traditional fuels like oil shale are becoming more economically important. Australia has >33 billion tonnes of oil shales resources with potential for >1800 million tonnes of recoverable oil. This potential multi-billion dollar industry depends upon development of an efficient technology leading to economical oil production and much cleaner organic liquid ....A study of high temperature transformation of oil shale - In-situ mineral reactions and structure analysis. In the current energy market, non-traditional fuels like oil shale are becoming more economically important. Australia has >33 billion tonnes of oil shales resources with potential for >1800 million tonnes of recoverable oil. This potential multi-billion dollar industry depends upon development of an efficient technology leading to economical oil production and much cleaner organic liquid fuels. Retorting and combustion, which are core parts of oil shale conversion technology, would benefit from improved process conditions. This research proposal intends to investigate the in-situ complex oil shale thermal conversion reactions that occur during the retorting and combustion processes. Improved understanding of these complex reactions could lead to substantial economic and environmental improvements in oil shale processing.Read moreRead less