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Structural Characterization Of A Novel AB5 Cytoxin - SubAB
Funder
National Health and Medical Research Council
Funding Amount
$210,760.00
Summary
The proposed research program, using a combinantion of structural biology and biophysical techniques will provide insight into the role of novel AB5 toxin from E. coli. This study will not only improve our fundamental understanding the mode of action of this toxin from this devastating pathogen, but could lead to the design of rational antimicrobials. The knowledge gained will increase Australian international research profile.
Structural Analysis Of Poxvirus Immature Particles And Spheroids
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Despite the eradication of smallpox by vaccination, poxviruses remain a threat to public health because of bioterrorist scares from kept variola stocks and because of the possible emergence of other poxvirus pathogens from the extensive animal reservoir. The structural analysis of the assembly of poxvirus will not only improve our knowledge of fundamental processes, highly conserved in DNA viruses, but could also provide valuable targets for the rational design of antiviral drugs.
A Targeted Nutrient-depletion Approach To Tackle Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
Prostate cancer is the most prevalent male specific cancer, and has a similar incidence to breast cancer in women. We are studying the role of protein pumps that control the amount of nutrients taken into and out of cancer cells. We are aiming to structurally determine LAT1 and LAT3, two nutrient pumps important for cancer progression, and to use these structures as a platform for drug design where the intention is to drugs 'starve’ the cancer by restricting nutrient uptake.
Peripheral Membrane Proteins In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$469,151.00
Summary
Peripheral membrane proteins are critical for processes such as cell transport, signaling, neurosecretion and development. As such, their dysfunction can lead to many debilitating diseases including cancer, inflammation and neurodegeneration. This project will establish fundamental new knowledge about how peripheral membrane proteins regulate cell function, how their perturbation or mutation results in human disease, and will inform efforts to target them for future therapeutic outcomes.