The proposal is to set-up a high-standard cell culture facility that will enable the establishment of a national repository of quality-controlled vertebrate cell lines derived from various tissues and species. This will facilitate high quality studies in a wide range of areas of basic health and medical research and in biotechnology.
Building A Bridge Between Animal Models Of Blood Transfusion And Clinical Practice: Development Of Sheep Laboratory Models To Investigate The Effects Of Transfusion
Funder
National Health and Medical Research Council
Funding Amount
$86,117.00
Summary
This research project aims to develop clinically-relevant sheep laboratory models of transfusion that will provide a ‘bridge’ between human laboratory and sheep in vivo models and clinical setting by contributing to a better understanding of the underlying mechanisms of transfusion with stored blood products. Ultimately, addressing key knowledge gaps regarding transfusion of aged and cryopreserved blood products will result in improved outcomes for patients.
The Effect Of Oxygen Tension On Primary And Primordial Follicle Activation In The Primate Ovary
Funder
National Health and Medical Research Council
Funding Amount
$403,956.00
Summary
Oncofertility, bridges oncology and reproductive medicine in order to apply new fertility preservation options for young patients with fertility-threatening diseases or treatments. Development of the three dimensional (3-D) tissue culture system for follicle maturation is a novel method of replicating the native environment of the growing egg. The ultimate goal of the project is to develop and optimise an in vitro culture procedure that can be translated to support human follicle development.
Transplantation of frozen ovarian tissue is being used by young patients at risk of losing ovarian function. This study aims to maximize the likelihood that patients who have ovarian tissue collected, frozen and returned will acheive the desired outcome of returning ovarian hormonal cyclicity, ovulation, or fertility.