Mechanisms Of Macrophage Activation By Immunostimulatory DNA
Funder
National Health and Medical Research Council
Funding Amount
$230,728.00
Summary
This project is based upon the observation that the mammalian immune system can distinguish between its own genetic material (DNA) and the genes of infectious agents such as bacteria. This fact has implications for understanding how the immune system copes with infection, and also for design of new therapies and vaccines. Our central aim is to define exactly how this recognition system works. The cells that respond most vigorously to foreign DNA are large white blood cells called macrophages. We ....This project is based upon the observation that the mammalian immune system can distinguish between its own genetic material (DNA) and the genes of infectious agents such as bacteria. This fact has implications for understanding how the immune system copes with infection, and also for design of new therapies and vaccines. Our central aim is to define exactly how this recognition system works. The cells that respond most vigorously to foreign DNA are large white blood cells called macrophages. We aim to find the macrophage protein which binds to foreign DNA and triggers the activation of the immune system. The type of immune responses initiated by foreign DNA may be useful in treatment of allergies and cancer and for improving vaccinations.Read moreRead less
The First Polynesians: Their Origins, Lifeways and Environmental Challenges. This project uses an interdisciplinary approach to examine the biological, cultural and environmental factors underpinning the Polynesian people through a study of their ancient homeland in Tonga. Early Polynesian society developed 2650-2350 years ago, but little is known about the people, their culture and how sea-level fall impacted subsistence and settlement. The proposed study’s goal is to fill this gap in human kno ....The First Polynesians: Their Origins, Lifeways and Environmental Challenges. This project uses an interdisciplinary approach to examine the biological, cultural and environmental factors underpinning the Polynesian people through a study of their ancient homeland in Tonga. Early Polynesian society developed 2650-2350 years ago, but little is known about the people, their culture and how sea-level fall impacted subsistence and settlement. The proposed study’s goal is to fill this gap in human knowledge about our Pacific neighbours using a unique skeletal assemblage, excavated cultural remains and advanced mapping of palaeo-sea-level markers that will improve understanding of the impact of environmental change on human societies in our region.Read moreRead less
Warfare and the Archaic State in Oceania. The project aim is to investigate warfare in the ancient Tongan state through a study of earthwork fortifications. The conflict record for an Archaic state in Oceania that survived for 650 years contributes a new perspective to global research on warfare in complex societies. The effect of conflict is a prominent issue for Australia and long-term records of warfare in our region will improve our understanding of it. Intra-state conflict is the most press ....Warfare and the Archaic State in Oceania. The project aim is to investigate warfare in the ancient Tongan state through a study of earthwork fortifications. The conflict record for an Archaic state in Oceania that survived for 650 years contributes a new perspective to global research on warfare in complex societies. The effect of conflict is a prominent issue for Australia and long-term records of warfare in our region will improve our understanding of it. Intra-state conflict is the most pressing threat to political stability in South-East Asia and the Pacific and the project would benefit Australia by showing how changes to political systems are associated with phases of conflict and peace.Read moreRead less
Before, during and after Lapita: 5000 years of cultural continuity and transformation at Caution Bay, southern Papua New Guinea. Australia's closest Indigenous neighbours in southern Papua New Guinea have long been thought to have been in contact with long-distance seafarers only in the last 2000 years. This project will document recent archaeological findings that are causing a radical rethink of ancestral connections between Australia and southern Papua New Guinea.
Discovery Early Career Researcher Award - Grant ID: DE200100597
Funder
Australian Research Council
Funding Amount
$399,551.00
Summary
Pacific Matildas: finding the women in the history of Pacific archaeology. This project aims to investigate the scientific lives and contributions of women in the development of a particular discipline; using Pacific archaeology as a case study. The history of science has traditionally produced gender biased narratives, so an innovative interdisciplinary approach will be developed to document the hidden role of women in the history of archaeology. New knowledge will be generated in the history o ....Pacific Matildas: finding the women in the history of Pacific archaeology. This project aims to investigate the scientific lives and contributions of women in the development of a particular discipline; using Pacific archaeology as a case study. The history of science has traditionally produced gender biased narratives, so an innovative interdisciplinary approach will be developed to document the hidden role of women in the history of archaeology. New knowledge will be generated in the history of science, archaeology and gender studies. Anticipated outcomes include (i) a more inclusive history that provides diverse role models of women in science from our region, (ii) the identification of socio-cultural patterns limiting women's careers and successful strategies historically developed to overcome these.Read moreRead less
Excavating MacGregor: re-connecting a colonial museum collection. Sensing the impacts of colonisation, the first Administrator of British New Guinea William MacGregor made a significant collection of objects specifically for its future citizens. This comprehensive legacy of 13 000 objects did not remain in the country but was dispersed to three Australian and six overseas museums. Our aim is to re-assemble and re-connect this material by 'excavating' its private and official components. This res ....Excavating MacGregor: re-connecting a colonial museum collection. Sensing the impacts of colonisation, the first Administrator of British New Guinea William MacGregor made a significant collection of objects specifically for its future citizens. This comprehensive legacy of 13 000 objects did not remain in the country but was dispersed to three Australian and six overseas museums. Our aim is to re-assemble and re-connect this material by 'excavating' its private and official components. This research aims to focus on the makers and traders to disentangle the social relationships embedded in the objects. Using material-centred, assemblage-based archaeological approaches, we aim to investigate how indigenous groups used objects to negotiate with the new colonial government.Read moreRead less