Osteosarcoma is the most common tumour of bone. Recent success in targeting immune checkpoint blockers such as Programmed death-1 (PD-1) in genomically complex tumours suggests that osteosarcomas may be amenable to such strategies. We will characterise the role of the PD-1 pathway in osteosarcoma development and growth. Using preclinical mouse models we will investigate the biology of the PD-1 pathway and study its potential as a therapeutic target in advanced and resectable osteosarcoma.
Combating Bacterial ‘superbugs‘ By Innovative Dosing Strategies That Combine Available Antibiotics To Prevent Resistance
Funder
National Health and Medical Research Council
Funding Amount
$547,694.00
Summary
As resistant bacterial ‘superbugs’ are among the 3 most serious threats to global health and as new antibiotics are lacking, innovative strategies to prevent bacterial resistance are urgently needed. This proposal will yield molecular insights on optimal combinations of current beta-lactam antibiotics to maximise bacterial killing without resistance. This project will provide guidance to physicians on how to optimally combine available beta-lactam antibiotics to prevent bacterial resistance.
Community variations in crime: A spatial and ecometric analysis. Collective Efficacy (CE) is a new theoretical construct (that has never been investigated in Australia). It is a task-specific process for mobilising social capital to tackle specific neighbourhood problems. Research in Chicago finds that communities with high levels of CE experience lower levels of violence regardless of poverty levels. We will conduct a spatial and ecometric analysis of CE and crime using a survey of 3000 residen ....Community variations in crime: A spatial and ecometric analysis. Collective Efficacy (CE) is a new theoretical construct (that has never been investigated in Australia). It is a task-specific process for mobilising social capital to tackle specific neighbourhood problems. Research in Chicago finds that communities with high levels of CE experience lower levels of violence regardless of poverty levels. We will conduct a spatial and ecometric analysis of CE and crime using a survey of 3000 residents in 50 Brisbane communities. We will compare similar data from Chicago and Stockholm to investigate the Australian contribution of CE to spatial crime patterns and its potential for future crime prevention programs.Read moreRead less
The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.
The many moral rationalisms. This project addresses the foundations of morality. It contributes to our self-understanding by generating new insights into the objectivity of morality and into the role of reason and emotion in moral judgment.
WOmen's Action For Mums And Bubs (WOMB): A Pragmatic Trial Of Participatory Women's Groups To Improve Indigenous Maternal And Child Health
Funder
National Health and Medical Research Council
Funding Amount
$1,766,216.00
Summary
There is strong evidence elsewhere that involving community women in decision-making about strategies to improve the health of mothers and babies is a cheap and effective way of improving health. The WOMB study tests whether community women's groups improve the quality of maternal and child health care and outcomes in Aboriginal and Torres Strait Islander communities, the cost-effectiveness and how it works.
Integrated Kids Hubs - Ensuring Equity of Access for Children. The Integrated Kids Hubs - Ensuring Equity of Access for Children project aims to determine if integrated Hubs are effective in increasing access to child and family services for disadvantaged urban and regional families with children aged 3 years and under, thus improving early identification of developmental vulnerability, parental wellbeing and capacity, and addressing unmet psychosocial needs. If these issues are not identified a ....Integrated Kids Hubs - Ensuring Equity of Access for Children. The Integrated Kids Hubs - Ensuring Equity of Access for Children project aims to determine if integrated Hubs are effective in increasing access to child and family services for disadvantaged urban and regional families with children aged 3 years and under, thus improving early identification of developmental vulnerability, parental wellbeing and capacity, and addressing unmet psychosocial needs. If these issues are not identified and addressed early, these children will go on to struggle in school and life. We will use a pragmatic trial design (meaning the research is embedded in our usual practice), determine the social return on investment, and establish what is needed to scale up the Hubs across NSW and Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100154
Funder
Australian Research Council
Funding Amount
$399,000.00
Summary
Theory use in social care practice: improving implementation and outcomes . This project aims to harness the power of theorising to advance implementation science. The project expects to generate new knowledge on how frontline workers can use and move beyond their tacit knowledge to strengthen the implementation and effectiveness of programs designed to address pervasive disadvantage and promote positive child and family outcomes. The expected outcome is a tested theoretical model that will inf ....Theory use in social care practice: improving implementation and outcomes . This project aims to harness the power of theorising to advance implementation science. The project expects to generate new knowledge on how frontline workers can use and move beyond their tacit knowledge to strengthen the implementation and effectiveness of programs designed to address pervasive disadvantage and promote positive child and family outcomes. The expected outcome is a tested theoretical model that will inform how frontline workers' critical thinking supports the consolidation of tacit and new knowledge and the use of implementation science. Strengthening understanding of effective program implementation through theory driven inquiry is viable and may generate urgently needed population level change in the social care sector. Read moreRead less
Womens access to welfare after prison - an international comparison. The aim of the proposed research is to undertake an comparative analysis of the services accessed by female prisoners following their return to the community and the potential of these services to reduce re-offending. This analysis will build upon the current ARC project in Victoria and a similar project in Scotland. Scotland and Victoria provide an interesting focus for comparative research, having similar populations, similar ....Womens access to welfare after prison - an international comparison. The aim of the proposed research is to undertake an comparative analysis of the services accessed by female prisoners following their return to the community and the potential of these services to reduce re-offending. This analysis will build upon the current ARC project in Victoria and a similar project in Scotland. Scotland and Victoria provide an interesting focus for comparative research, having similar populations, similar numbers of women imprisoned and similar increases during the last decade in the daily female prison population. Moreover in both jurisdictions initiatives are being introduced to enhance women's access to services when they leave prison.
The purpose of the proposed research will be to develop and implement a framework for the comparative analysis of data on women's experiences after prison that will be generated by two funded studies in Scotland and Victoria.Read moreRead less
Women's access to welfare after prison. This project aims to examine the nature of welfare services available to women after they leave Victorian prisons, how the women access these services and the extent to which the services meet their needs and contribute to their rehabilitation. Although female ex-offenders are likely to have a high need for welfare services, and the evidence suggests that these services can make a difference to their successful re-integration, little is known about whether ....Women's access to welfare after prison. This project aims to examine the nature of welfare services available to women after they leave Victorian prisons, how the women access these services and the extent to which the services meet their needs and contribute to their rehabilitation. Although female ex-offenders are likely to have a high need for welfare services, and the evidence suggests that these services can make a difference to their successful re-integration, little is known about whether and how women access services or benefit from them. The results of the project will inform the development of welfare services by the industry partner and elsewhere.
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