Proteomics And Confocal Endomicroscopy In The Evaluation Of Inflammatory Bowel Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$436,096.00
Summary
Inflammatory bowel diseases (IBD) result in devastating consequences and affect more young Australians than epilepsy or road traffic accidents. Damaged bowel results in loss of the normal gut barrier and flora can enter the tissue and even the blood. This concept of the "leaky gut" has been previously difficult to demonstrate. This can now be seen and measured using two new technologies called proteomics and confocal endomicroscopy. These tests offer new avenues of research for the 61,000 Austra ....Inflammatory bowel diseases (IBD) result in devastating consequences and affect more young Australians than epilepsy or road traffic accidents. Damaged bowel results in loss of the normal gut barrier and flora can enter the tissue and even the blood. This concept of the "leaky gut" has been previously difficult to demonstrate. This can now be seen and measured using two new technologies called proteomics and confocal endomicroscopy. These tests offer new avenues of research for the 61,000 Australian sufferers of IBD.Read moreRead less
Role Of Inflammation In The Physiological And Pathological Function Of The Gastrointestinal Tract
Funder
National Health and Medical Research Council
Funding Amount
$443,946.00
Summary
The gastrointestinal tract is continuously exposed to the external environment as a consequence of what we ingest. We have therefore evolved distinct mechanisms to deal with exposure to non-pathogenic insults in the gut. Sometimes, however these mechanisms fail leading to chronic inflammation and resultant pathology, which can under certain circumstances develop into cancer. This study will investigate inflammation in the gut, with particular interest in the systems that control inflammation.