A Randomised Trial Of The Augmentation Of Cognitive Behaviour Therapy With Fluoxetine For Anxious School Refusing Youth
Funder
National Health and Medical Research Council
Funding Amount
$539,191.00
Summary
School refusing youth consistently suffer from anxiety and sometimes depression. They become severely emotionally distressed when taken to school and experience social and academic difficulties in the short and long term as well as psychiatric illness in adulthood. Our program investigates whether treatment can be improved by enhancing psychotherapy (cognitive behaviour therapy) which helps over half of anxious school refusing children, with antidepressant-anxiety medication compared to placebo.
Modelling human decision making in complex environments. The project aims to extend quantitative psychological models of simple choice tasks to decision-making with complex stimuli in complex environments. The new formal models are designed to provide a comprehensive account of behaviour, including the choices that are made, how long it takes to make them, and how choices and choice times vary within and between decision-makers. The models would explain how people adapt to changes in task demand ....Modelling human decision making in complex environments. The project aims to extend quantitative psychological models of simple choice tasks to decision-making with complex stimuli in complex environments. The new formal models are designed to provide a comprehensive account of behaviour, including the choices that are made, how long it takes to make them, and how choices and choice times vary within and between decision-makers. The models would explain how people adapt to changes in task demands when dealing with multiple stimuli or performing multiple tasks concurrently under time pressure. The project aims to provide the basic research that is needed to extend psychological models of choice to complex ‘real-world’ tasks, such air traffic control and maritime surveillance.Read moreRead less
Creating a climate for change: from cognition to consensus. Climate change is a significant contemporary issue, and communicating the complexities of the terminology and the data is a major modern challenge. This project will apply principles of cognitive and social psychology to determine the most effective methods for promoting an understanding of the scientific dimensions of the issue. The research is significant because it provides a coherent theoretical framework for identifying the psychol ....Creating a climate for change: from cognition to consensus. Climate change is a significant contemporary issue, and communicating the complexities of the terminology and the data is a major modern challenge. This project will apply principles of cognitive and social psychology to determine the most effective methods for promoting an understanding of the scientific dimensions of the issue. The research is significant because it provides a coherent theoretical framework for identifying the psychological mechanisms underlying cognition and commitment at both an individual and collective level. The outcome will be a body of evidence that will inform strategies and policies for communication of complex scientific questions.Read moreRead less
Spatial Cognition—Expressive Representation Formalisms and Effective Reasoning Mechanisms. The project will contribute significantly to the advancement of knowledge in breakthrough science in qualitative spatial reasoning and smart information use in geographic information systems. Expressive spatial languages are important in organising spatial knowledge, defining spatial query languages and guiding spatial data mining. Effective spatial reasoning mechanisms bring theory closer to applications ....Spatial Cognition—Expressive Representation Formalisms and Effective Reasoning Mechanisms. The project will contribute significantly to the advancement of knowledge in breakthrough science in qualitative spatial reasoning and smart information use in geographic information systems. Expressive spatial languages are important in organising spatial knowledge, defining spatial query languages and guiding spatial data mining. Effective spatial reasoning mechanisms bring theory closer to applications including consistency checking and spatial query pre-processing. The project will help in extracting knowledge from massive spatial databases, meeting the growing needs of naive users for spatial information and establishing Australia as a major player in spatial cognition research and in the development of geo-location services.Read moreRead less
Judgements and Decisions under Ambiguity and Conflict. Little is known about how people make decisions when faced with uncertainties arising from information that is both ambiguous and conflicting, despite the fact that ambiguity and conflict frequently arise in real decision-making situations. In fact, virtually nothing is known about the joint impact of conflict and ambiguity on judgements of risk and uncertainty or on decisional preferences. This project will investigate how perceptions of un ....Judgements and Decisions under Ambiguity and Conflict. Little is known about how people make decisions when faced with uncertainties arising from information that is both ambiguous and conflicting, despite the fact that ambiguity and conflict frequently arise in real decision-making situations. In fact, virtually nothing is known about the joint impact of conflict and ambiguity on judgements of risk and uncertainty or on decisional preferences. This project will investigate how perceptions of uncertainty are jointly affected by conflict and ambiguity in information, develop and test formal models of judgement and decision making under conflict and ambiguity, and examine the joint effects of ambiguity and conflict aversion on decision making.Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Zero-sum thinking: psychological predictors and causes. This project investigates the causes and psychological triggers of zero-sum thinking, the tendency to think that others' gains leave less for oneself. The results will enable negotiators and managers to defuse dysfunctional zero-sum thinking, thereby increasing the chances for cooperation and 'win-win' outcomes.