Creating a climate for change: from cognition to consensus. Climate change is a significant contemporary issue, and communicating the complexities of the terminology and the data is a major modern challenge. This project will apply principles of cognitive and social psychology to determine the most effective methods for promoting an understanding of the scientific dimensions of the issue. The research is significant because it provides a coherent theoretical framework for identifying the psychol ....Creating a climate for change: from cognition to consensus. Climate change is a significant contemporary issue, and communicating the complexities of the terminology and the data is a major modern challenge. This project will apply principles of cognitive and social psychology to determine the most effective methods for promoting an understanding of the scientific dimensions of the issue. The research is significant because it provides a coherent theoretical framework for identifying the psychological mechanisms underlying cognition and commitment at both an individual and collective level. The outcome will be a body of evidence that will inform strategies and policies for communication of complex scientific questions.Read moreRead less
Spatial Cognition—Expressive Representation Formalisms and Effective Reasoning Mechanisms. The project will contribute significantly to the advancement of knowledge in breakthrough science in qualitative spatial reasoning and smart information use in geographic information systems. Expressive spatial languages are important in organising spatial knowledge, defining spatial query languages and guiding spatial data mining. Effective spatial reasoning mechanisms bring theory closer to applications ....Spatial Cognition—Expressive Representation Formalisms and Effective Reasoning Mechanisms. The project will contribute significantly to the advancement of knowledge in breakthrough science in qualitative spatial reasoning and smart information use in geographic information systems. Expressive spatial languages are important in organising spatial knowledge, defining spatial query languages and guiding spatial data mining. Effective spatial reasoning mechanisms bring theory closer to applications including consistency checking and spatial query pre-processing. The project will help in extracting knowledge from massive spatial databases, meeting the growing needs of naive users for spatial information and establishing Australia as a major player in spatial cognition research and in the development of geo-location services.Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Leadership, social identity and the dynamics of influence in intergroup relations: A new understanding of social continuity and social change. Understanding how social change occurs (or continuity prevails) and the role of leadership in this process is paramount to any social system (e.g. nation, state, organization, team). This project provides a new social psychological understanding of leadership and social change dynamics, including when more radical leaders and social relations emerge, as w ....Leadership, social identity and the dynamics of influence in intergroup relations: A new understanding of social continuity and social change. Understanding how social change occurs (or continuity prevails) and the role of leadership in this process is paramount to any social system (e.g. nation, state, organization, team). This project provides a new social psychological understanding of leadership and social change dynamics, including when more radical leaders and social relations emerge, as well as how different groups become more united around a common cause. Given ethnic, religious, social and political diversity of Australian society, these questions are fundamental to strengthening Australia's social fabric. This research also has cross-disciplinary applications, builds international collaborations, and supports emerging Australian research talent.Read moreRead less
The high cost of bad bosses: Reactions of employees, co-workers, and employees' partners to abusive supervision. Abusive supervision has serious consequences for individuals and organisations. It is detrimental to employee well-being, reduces productivity, and may even result in litigation. We examine the negative effects of abusive supervision not only on employees but also on those around them: their co-workers and families. Our proposed intervention is a major step towards empowering employee ....The high cost of bad bosses: Reactions of employees, co-workers, and employees' partners to abusive supervision. Abusive supervision has serious consequences for individuals and organisations. It is detrimental to employee well-being, reduces productivity, and may even result in litigation. We examine the negative effects of abusive supervision not only on employees but also on those around them: their co-workers and families. Our proposed intervention is a major step towards empowering employees to effectively manage the aftermath of supervisory mistreatment. The outcomes of this research will demonstrate the need for organisations and governmental agencies to invest more resources in the prevention of these harmful supervisory practices.Read moreRead less
ARC/NHMRC Research Network in Ageing Well. The ARC Research Network on Ageing Well will support interdisciplinary, high quality research in the National Research Priority Goal of Ageing Well, Ageing Productively. It will build scale and focus on Australia's notable research strengths in ageing, promote collaborative research, and extend research capacities. The Network will link outstanding researchers from many disciplines, nurture developing researchers, relate social to health researchers, s ....ARC/NHMRC Research Network in Ageing Well. The ARC Research Network on Ageing Well will support interdisciplinary, high quality research in the National Research Priority Goal of Ageing Well, Ageing Productively. It will build scale and focus on Australia's notable research strengths in ageing, promote collaborative research, and extend research capacities. The Network will link outstanding researchers from many disciplines, nurture developing researchers, relate social to health researchers, strengthen international collaboration, and involve and inform end-point users. It will foster research which responds to the aspirations and needs of older Australians and informs action that can improve experiences of individual and population ageing.Read moreRead less
Estimating And Alleviating The Impacts Of Age-Related Sensory Decline
Funder
National Health and Medical Research Council
Funding Amount
$323,767.00
Summary
Sensory loss and dementia disproportionately affect older adults, often co-occur, and are the two leading contributors to disability burden among older Australians. This research will investigate the consequences that hearing and vision loss have for older adult health and wellbeing, informing strategies to reduce the disability burden of age-related sensory loss. These impacts include cognitive decline and dementia, mental health, quality of life, disability and independent living.
Humanisation And Pre-clinical Validation Of A Therapeutic Anti-cancer Antibody
Funder
National Health and Medical Research Council
Funding Amount
$699,136.00
Summary
This grant will develop a novel antibody against a protease expressed on cancer cells. Preclinical studies, and antibody humanisation, will be performed. This project will also provide vital information on optimal therapeutic approaches with the antibody that can be ultimately taken into human trials.