Discovery And Mechanisms Of Host Cell Factors In HIV Uncoating
Funder
National Health and Medical Research Council
Funding Amount
$635,098.00
Summary
HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.
Inhibition Of Cellcell Actin-based Motility During Poxvirus Infection By The Kinase Inhibitor Glivec
Funder
National Health and Medical Research Council
Funding Amount
$92,950.00
Summary
Although smallpox, one of the deadliest human pathogens, was eradicated in 1980, the current global climate has resulted in fears that smallpox may be used as a biological weapon. Unfortunately the smallpox vaccine poses a serious health hazard to certain people. We have shown that Glivec, a drug used to treat cancer, has potent anti-viral affects on poxvirus replication. This project will test the effectiveness of Glivec in treating smallpox in an animal model and study how it acts.
Scalable Visual Analytics for Uncertain Dynamic Networks. Technological advances have provided a data deluge over the past few years, and have led to many large uncertain and dynamic network models. This includes terrorist networks, marketing networks, facebook networks, various biological networks, and software engineering structures. Human understanding of such networks is difficult. This project aims to provide new methods for visual analysis of large uncertain dynamic networks such as these. ....Scalable Visual Analytics for Uncertain Dynamic Networks. Technological advances have provided a data deluge over the past few years, and have led to many large uncertain and dynamic network models. This includes terrorist networks, marketing networks, facebook networks, various biological networks, and software engineering structures. Human understanding of such networks is difficult. This project aims to provide new methods for visual analysis of large uncertain dynamic networks such as these. The algorithms developed in the project will help security analysts to monitor illegal behaviour such as money laundering and terrorist activities, help biologists understand key biological systems, and help engineers to understand large software systems.Read moreRead less
Prion-like Behaviour In Immunity: Super-sized Signalling Platforms?
Funder
National Health and Medical Research Council
Funding Amount
$611,995.00
Summary
Prions have been mostly associated with pathologies but recent discoveries show that prion-like behaviour may be beneficial, enhancing our immune response for example. To test this, we want to systematically explore all human proteins involved in the defence against pathogens, find new prion-like trends and probe their role in the innate immune response.
Discovery Early Career Researcher Award - Grant ID: DE180101416
Funder
Australian Research Council
Funding Amount
$338,446.00
Summary
Broadening horizons: using curiosity to diversify behaviour. This project aims to explore how interactive systems can encourage their users to try new things. This is made possible by recent developments in artificial intelligence that can estimate what will make users curious. This project expects to generate new knowledge about how interactive technology can encourage diverse behaviour by stimulating curiosity. Expected outcomes include a framework for how to design interactive systems that en ....Broadening horizons: using curiosity to diversify behaviour. This project aims to explore how interactive systems can encourage their users to try new things. This is made possible by recent developments in artificial intelligence that can estimate what will make users curious. This project expects to generate new knowledge about how interactive technology can encourage diverse behaviour by stimulating curiosity. Expected outcomes include a framework for how to design interactive systems that encourage users to try new things, and a greater theoretical understanding of how to diversify user behaviour.Read moreRead less
Using 3D printing to improve access to graphics by vision-impaired people. This project aims to investigate the possible benefits of 3D printing for production of accessible materials for vision-impaired people. Currently tactile graphics are used to provide severely vision-impaired adults and children with access to graphical content used in education and in orientation and mobility training. This project is expected to clarify the kinds of graphics for which 3D prints are better suited than ta ....Using 3D printing to improve access to graphics by vision-impaired people. This project aims to investigate the possible benefits of 3D printing for production of accessible materials for vision-impaired people. Currently tactile graphics are used to provide severely vision-impaired adults and children with access to graphical content used in education and in orientation and mobility training. This project is expected to clarify the kinds of graphics for which 3D prints are better suited than tactile graphics, and to build capacity within the national accessible format provision sector for the production and use of 3D prints. Benefits will include increased educational opportunities and quality of life for Australians with severe vision impairment, through improved access to graphic materials used in education and orientation and mobility training.
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Integrating human operators into large-scale sensor networks. Information awareness is critical in many applications of national importance: from bush fire fighting and defence to transportation and health care. These applications involve tasks in which timely delivery and fusion of heterogeneous information streams is of critical importance. They can all benefit from the use of robotic and embedded sensor networks considered in this project. Human operators, acting as users or supervisors, will ....Integrating human operators into large-scale sensor networks. Information awareness is critical in many applications of national importance: from bush fire fighting and defence to transportation and health care. These applications involve tasks in which timely delivery and fusion of heterogeneous information streams is of critical importance. They can all benefit from the use of robotic and embedded sensor networks considered in this project. Human operators, acting as users or supervisors, will remain at the centre of these systems. The technology and algorithms developed in this project will efficiently structure information exchange between humans and sensor networks. Establishing Australian leadership in this fast-evolving high-technology field will spur growth and job creation.Read moreRead less
Gesture-controlled interaction to enrich information access. This project is a study of gestural computing (enabled by sensors such as pressure mats, infra-red sensors and video tracking) which aims to move away from desk-bound, restrictive computing environments and towards computing that is more integral to the building structure and space itself. Linking gesture controllers and information sonification delivers a unique bridge between data and human interaction. Enriching the capacity to acce ....Gesture-controlled interaction to enrich information access. This project is a study of gestural computing (enabled by sensors such as pressure mats, infra-red sensors and video tracking) which aims to move away from desk-bound, restrictive computing environments and towards computing that is more integral to the building structure and space itself. Linking gesture controllers and information sonification delivers a unique bridge between data and human interaction. Enriching the capacity to access information in dense workplace environments is central to improved efficiency across the Australian workforce. Greater accuracy and enhanced techniques for controlling information in visually-overloaded work environments contribute to Australia's competitive leadership in a global marketplace.Read moreRead less
Streaming video media using semantic information. Delivering video over the Internet has posted a big problem. Video files are extremely big and need hours or even tens of hours to download. This is too long to wait for the content. Much research has been attempted over low-level structures such as coding, buffer, protocol, agent and server. These techniques are either not scalable or impractical. This project aims to collaborate with CyberView on developing a high-level scheme of streaming vide ....Streaming video media using semantic information. Delivering video over the Internet has posted a big problem. Video files are extremely big and need hours or even tens of hours to download. This is too long to wait for the content. Much research has been attempted over low-level structures such as coding, buffer, protocol, agent and server. These techniques are either not scalable or impractical. This project aims to collaborate with CyberView on developing a high-level scheme of streaming video using semantic information. It breaks videos into shots and allows semantic browsing of the content. It also introduces intelligent agents with various behaviours.Read moreRead less