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Research Topic : CO-ENZYME Q10
Socio-Economic Objective : Expanding Knowledge in the Biological Sciences
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  • Researchers (45)
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  • Funded Activity

    Discovery Projects - Grant ID: DP130103141

    Funder
    Australian Research Council
    Funding Amount
    $345,000.00
    Summary
    The protein O-glycosylation pathway of Neisseria: a model system for O-glycosylation of bacterial proteins with potential use in biotechnology. Proteins can be modified by the addition of sugar molecules. This process, called glycosylation, has been studied for some time in humans and other higher organisms, but is relatively new in the field of bacteria. This study will use the bacterium Neisseria as a model system for this process and work to harness the system for use in biotechnology.
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    Active Funded Activity

    Discovery Projects - Grant ID: DP210101757

    Funder
    Australian Research Council
    Funding Amount
    $561,428.00
    Summary
    Combining new synthetic biology tools to boost crop CO2 capture and growth. A solution for improving crop yield is to enhance the carbon dioxide fixation properties of the enzyme Rubisco whose inefficient activity often limits plant growth. This project makes use of new synthetic biology capabilities to artificially evolve Rubisco in the laboratory and select for new versions with improved performance. These beneficial changes will be introduced into crop Rubisco using targeted gene editing appr .... Combining new synthetic biology tools to boost crop CO2 capture and growth. A solution for improving crop yield is to enhance the carbon dioxide fixation properties of the enzyme Rubisco whose inefficient activity often limits plant growth. This project makes use of new synthetic biology capabilities to artificially evolve Rubisco in the laboratory and select for new versions with improved performance. These beneficial changes will be introduced into crop Rubisco using targeted gene editing approaches and the improvements in photosynthesis, growth and yield evaluated. This information will aid complimentary biotechnological efforts seeking to supercharge photosynthesis and help deliver the second Green Revolution needed to meet the improvement required in future agriculture productivity and resource use.
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    Funded Activity

    Discovery Projects - Grant ID: DP150101371

    Funder
    Australian Research Council
    Funding Amount
    $355,100.00
    Summary
    Design and engineering of proteins for biotechnology and biomedicine. The primary aim of this application is to enhance the thermodynamic and folding properties of proteins by redesign and engineering. The structures and folding behaviour of the redesigned proteins will be characterised using X-ray crystallography and biophysical techniques. The expected outcomes of this project are: engineering of new proteins that can be used in biotechnology, medical and pharmaceutical applications, or basic .... Design and engineering of proteins for biotechnology and biomedicine. The primary aim of this application is to enhance the thermodynamic and folding properties of proteins by redesign and engineering. The structures and folding behaviour of the redesigned proteins will be characterised using X-ray crystallography and biophysical techniques. The expected outcomes of this project are: engineering of new proteins that can be used in biotechnology, medical and pharmaceutical applications, or basic research; fundamental insights into protein design and engineering; and a wealth of knowledge on the factors that dictate protein stability and folding.
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    Active Funded Activity

    Discovery Projects - Grant ID: DP200102837

    Funder
    Australian Research Council
    Funding Amount
    $451,284.00
    Summary
    Nano-reactors: Protein cages as reusable scaffolds for designer enzymes. This project aims to develop robust protein cages derived from the coats of viruses to contain heat-stable P450 enzymes, for use as specialised protein bio-catalysts in chemical industries. A valuable chemical precursor of renewable bio-plastics will be produced from seed oils by enzymes, reducing the use of fossil fuels. This synthetic biology approach combines biotechnology, nanotechnology and protein engineering to estab .... Nano-reactors: Protein cages as reusable scaffolds for designer enzymes. This project aims to develop robust protein cages derived from the coats of viruses to contain heat-stable P450 enzymes, for use as specialised protein bio-catalysts in chemical industries. A valuable chemical precursor of renewable bio-plastics will be produced from seed oils by enzymes, reducing the use of fossil fuels. This synthetic biology approach combines biotechnology, nanotechnology and protein engineering to establish a plant-based platform biotechnology for using enzymes as catalysts to make high-value molecules. The project aims to show how to engineer clean, sustainable chemistry in designer nano-environments. This should make synthetic processes more sustainable and enhance advanced chemical manufacturing in Australia.
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    Funded Activity

    Linkage Projects - Grant ID: LP170100717

    Funder
    Australian Research Council
    Funding Amount
    $460,800.00
    Summary
    Using photosynthesis to power fine chemical production. This project aims to develop robust, solar driven, enzyme-based biocatalysts to synthesise complex metabolites and biopharmaceutical molecules in single-cell micro-algae. The significance of this project is that solar energy is used to drive challenging chemical reactions inexpensively via photosynthesis. Expected outcomes include sustainable, solar driven production of high-value molecules that are difficult or impossible to synthesise che .... Using photosynthesis to power fine chemical production. This project aims to develop robust, solar driven, enzyme-based biocatalysts to synthesise complex metabolites and biopharmaceutical molecules in single-cell micro-algae. The significance of this project is that solar energy is used to drive challenging chemical reactions inexpensively via photosynthesis. Expected outcomes include sustainable, solar driven production of high-value molecules that are difficult or impossible to synthesise chemically. Benefits include proof-of-principle demonstration of new, light-driven green-chemistry processes for the production of biochemicals, biopharmaceuticals, agricultural and industrial chemicals, extending the diversity of molecules we can make while reducing cost and environmental impact of their production.
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