Central Neural Regulation Of Brown Fat Function – Glucose Sensing And CNS Pathways
Funder
National Health and Medical Research Council
Funding Amount
$761,942.00
Summary
Our research aims to identify how specific brain cells detect changes in glucose levels and how ageing and diet affect their function. We identified a subset of nerve cells that detect changes in glucose and the “hunger” hormone ghrelin, their ability to do so adapting with age and nutritional status. This project will investigate the potential of these nerve cells as targets for therapeutic and diet- intervention strategies to target obesity, diabetes and promote healthy ageing.
Centre For Research Excellence In Speech And Language Neurobiology (CRE-SLANG)
Funder
National Health and Medical Research Council
Funding Amount
$2,491,340.00
Summary
Half a million Australian children have a speech/language disorder, tripling their changes of poor academic outcomes, limited employment options and social isolation. Current speech therapy is limited, focusing on symptoms and ignoring evidence on underlying aetiologies. By identifying and translating findings on new genes and brain pathways leading to speech and language disorders, we will transform detection, diagnosis, prognosis and genetic counselling of affected children and their families.
Development of molecular markers for resistance to blackleg disease (Leptosphaeria maculans) in canola. Canola (Brassica napus) is a valuable oil seed crop grown in many parts of the world and contributes annually $A450 million to the Australian economy. The overall aim of this project is to develop molecular markers for blackleg resistance using Australian germplasm along with evaluation in Australian disease nurseries which are regarded worlwide to develop the highest levels of disease pressu ....Development of molecular markers for resistance to blackleg disease (Leptosphaeria maculans) in canola. Canola (Brassica napus) is a valuable oil seed crop grown in many parts of the world and contributes annually $A450 million to the Australian economy. The overall aim of this project is to develop molecular markers for blackleg resistance using Australian germplasm along with evaluation in Australian disease nurseries which are regarded worlwide to develop the highest levels of disease pressure. Once molecular marker systems are developed and evaluated, they will be applied to facilitate the selection of Nugrain's (Industry Partner) canola breeding programs. Any molecular markers and QTL developed for Australian cultivars would find commercial application in breeding programmes.Read moreRead less
The routes of infection with sheep scrapie and agents that cause related prion diseases. We will define the routes by which the infective agents for scrapie, a debilitating disease of sheep, reach the nervous system after being consumed with food. Scrapie is from the same disease group (prion diseases) as mad cow disease. There would be a large economic cost were prion diseases to infect agricultural animals in Australia, through bioterrorism or accident. An outbreak in sheep could ruin the indu ....The routes of infection with sheep scrapie and agents that cause related prion diseases. We will define the routes by which the infective agents for scrapie, a debilitating disease of sheep, reach the nervous system after being consumed with food. Scrapie is from the same disease group (prion diseases) as mad cow disease. There would be a large economic cost were prion diseases to infect agricultural animals in Australia, through bioterrorism or accident. An outbreak in sheep could ruin the industry, as our export markets would be immediately blocked, and thousands of animals would be killed to stop disease spread. The benefit of clearly understanding how the infective agents reach the nervous system is that this may lead to strategies to intervene, and thus limit the spread and seriousness of infection.Read moreRead less
Pathogenicity genes of the blackleg fungal pathogen of canola. Blackleg disease, caused by the fungus, Leptosphaeria maculans, is the most serious disease of canola (Brassica napus) Australia and worldwide. Control strategies require knowledge of mechanisms of both plant defence (resistance) and fungal pathogenicity; little is known about such processes for blackleg. I will make pathogenicity mutants of L.maculans (unable to attack canola) and characterise the mutated genes. This project will ....Pathogenicity genes of the blackleg fungal pathogen of canola. Blackleg disease, caused by the fungus, Leptosphaeria maculans, is the most serious disease of canola (Brassica napus) Australia and worldwide. Control strategies require knowledge of mechanisms of both plant defence (resistance) and fungal pathogenicity; little is known about such processes for blackleg. I will make pathogenicity mutants of L.maculans (unable to attack canola) and characterise the mutated genes. This project will develop a better understanding of the disease process for blackleg, identify novel disease control targets in this important fungus and lead to disease resistant canola.Read moreRead less
How Language Develops, What Goes Wrong, And Why It Matters: Following The Early Language In Victoria Study To Age 13
Funder
National Health and Medical Research Council
Funding Amount
$857,242.00
Summary
One in five children start school with low language. Little is known about the long term effects on developmental, educational attainment and other outcomes later in life. In this landmark study we will track the children's language, literacy and wellbeing from ages 8 to 12 years. We will capture the children's ability as they finish their primary school education and prior to the crucial transfer to high school.
Protecting the Australian chickpea industry through knowledge of the current Ascochyta rabiei fungal population and risk to resistance breeding strategies. Australian chickpea is highly vulnerable to epidemics of Ascochyta blight, which may cause total crop failure. This project will help to maintain Australia's position as a major global chickpea producer through maximising the life span of current resistance genes to A. rabiei. and determining the applicability of other potential resistance so ....Protecting the Australian chickpea industry through knowledge of the current Ascochyta rabiei fungal population and risk to resistance breeding strategies. Australian chickpea is highly vulnerable to epidemics of Ascochyta blight, which may cause total crop failure. This project will help to maintain Australia's position as a major global chickpea producer through maximising the life span of current resistance genes to A. rabiei. and determining the applicability of other potential resistance sources. The knowledge that will be generated regarding the pathogen's potential to overcome host resistance is imperative for developing future disease management strategies, especially since more aggressive isolates exist outside Australia. The project findings will feed directly into the National Australian Chickpea Breeding Program.Read moreRead less
Impaired Bone Remodelling Leads To Failure Of Orthopaedic Prostheses
Funder
National Health and Medical Research Council
Funding Amount
$515,917.00
Summary
The failure of bone prostheses is becoming a major health problem. More than 26,000 hip, and an equal number of knee, replacements were performed in Australia in 2002 with the number increasing between 5%-10% each year for the previous 10 years. Disturbingly, the incidence of revision hip surgery in Australia is now more than 15%, meaning that, despite the impressive success of joint replacement surgery, a significant number of arthroplasties fail. It is becoming more common for young, active in ....The failure of bone prostheses is becoming a major health problem. More than 26,000 hip, and an equal number of knee, replacements were performed in Australia in 2002 with the number increasing between 5%-10% each year for the previous 10 years. Disturbingly, the incidence of revision hip surgery in Australia is now more than 15%, meaning that, despite the impressive success of joint replacement surgery, a significant number of arthroplasties fail. It is becoming more common for young, active individuals to receive joint replacement surgery to improve their quality of life. This, combined with increasing life expectancy, and the known higher rate of failure of joint replacements in younger patients, means that the morbidity of a failed replacement, and the mobidity and associated mortality of revision surgery, will become an increasingly important health issue, with a major impact upon health budgets. The overwhelming majority of hip and knee prostheses have metal or ceramic on polyethylene bearing surfaces. It is now apparent that most implants fail due to bone loss around them leading to loosening, and evidence is accumulating that polyethylene wear particles are a major contributing factor to this process. It is therefore vital that we obtain better understanding of the causes of implant failure in order to extend the life of these implants and this project is designed to do so.Read moreRead less
The Role Of Interferon Signalling In The Regulation Of Stroke
Funder
National Health and Medical Research Council
Funding Amount
$620,381.00
Summary
This project focuses on the role that inflammation plays in the progression of the type of neural injury seen in stroke victims. This project targets a specific pathway that is thought to be involved in the regulation of general inflammation but has not been greatly investigated in terms of the neural injury seen in stroke. Understanding the actions of this pathway may lead to future therapies that can be used to prime the brain to react in a positive way to stroke.