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How Does Fampridine Affect Upper Limb Function In Multiple Sclerosis?
Funder
National Health and Medical Research Council
Funding Amount
$113,237.00
Summary
Multiple sclerosis (MS) is a common and disabling neurological disease affecting thousands of young Australians. In 2011 Fampridine received TGA approval for walking impairment in MS, but its mechanism of action is unknown and its effects on domains other than lower limb function remain untested. Our study will test whether Fampridine improves upper limb impairment in MS patients and will use electrophysiological measures of central nervous system conduction to uncover its mechanism of action.
Interactions Between Neuropeptide FF Receptor And Hypothalamic Neuropeptides In The Regulation Of Energy Homeostasis And Obesity
Funder
National Health and Medical Research Council
Funding Amount
$95,733.00
Summary
Despite the alarming obesity epidemic, there currently exists no effective long-term treatment for obesity. Neuropeptide FF and its receptor NPFF2R have an emerging role in regulating food intake and body fat stores. Results from this study will show whether NPFF2R plays an important role in regulating appetite, metabolic rate, body weight and fat stores, thus help to identify whether NPFF2R-targeted therapeutics would confer significant benefit for the long-term treatment of obesity.
Maternal Gut Microbiome During Pregnancy Influences Offspring Atopy And Asthma.
Funder
National Health and Medical Research Council
Funding Amount
$46,622.00
Summary
Allergic diseases such as food allergy and asthma have increased significantly as our exposure to bacteria has reduced. Many studies have explored exposure to bacteria in early life but few have examined the maternal bacteria we are exposed to while we develop in the womb. New studies indicate that we are exposed to many different components of our mothers gut bacteria and this might change our developing immune system and determine whether or not we get diseases like food allergy and asthma.
In Vivo Studies On Ventriculo-vascular Coupling And The Role Of Aortic Pressure Wave Morphology On Coronary Blood Flow
Funder
National Health and Medical Research Council
Funding Amount
$137,700.00
Summary
Heart disease is a leading cause of death and disability in Australia. Conditions resulting in reduced blood flow to the heart are particularly common and dangerous. Despite significant progress, we still do not understand exactly how changes in heart function and the aorta (the major artery arising from the heart) affect blood flow to the heart. This study will utilise sophisticated new techniques to look at the interactions between heart function, pressure in the aorta and coronary blood flow
Reference Values For Spirometry, Lung Volumes, Diffusing Capacity, And Fractional Exhaled Nitric Oxide In First Nations Australians
Funder
National Health and Medical Research Council
Funding Amount
$83,832.00
Summary
Reference values in lung function tests allow respiratory doctors to accurately interpret results in order to effectively diagnose, treat and manage respiratory disease. Currently, reference values do not exist for First Nations adults. I will recruit 600 healthy First Nations adults from communities in Queensland and the Northern Territory for several lung function tests. Data collected will be submitted to the Global Lung Function Initiative to be incorporated into future guidelines.
Effects Of Replacement And Withdrawal Of Testosterone In Human Males On Muscle, Bone And Fat
Funder
National Health and Medical Research Council
Funding Amount
$156,682.00
Summary
Male sex hormone or androgen deficiency (AD) is a common, but under-diagnosed condition. AD decreases well being and contributes to muscle weakness, bone fragility and weight gain. Cutting edge technology will be used to help explain how AD may relate to these negative effects, particularly on muscle function. Given the importance of aging, frailty, osteoporosis and obesity, understanding the role of hormones in these conditions may have major implications for prevention and treatment.
Cognitive And Psychosocial Functioning In Patients With Idiopathic Generalized Epilepsies
Funder
National Health and Medical Research Council
Funding Amount
$123,143.00
Summary
Children born extremely preterm are at risk of struggling at school and falling behind normal educational milestones, and having emotional problems such as anxiety. This study aims to see whether anxiety affects these children’s ability to learn and use new information. It will also determine whether an intervention targeting these thinking skills is less useful in children with higher levels of anxiety.
The Impact Of Early Experiences Of Stress And Depression On Cardiovascular Health: The Australian Lifestyle Of Our Kids (LOOK) Study
Funder
National Health and Medical Research Council
Funding Amount
$96,183.00
Summary
This study forms part of the LOOK study examining the link between lifestyle factors and children’s health. This research will investigate the impact of early experiences of stress and depression on cardiovascular health, whilst accounting for a set of potentially confounding variables (physical activity, fatness). The uniqueness of this study lies in the multidisciplinary approach and the breadth of measures collected. Poorer mental health is expected to predict poorer cardiovascular outcomes.