Intergenerational Transmission of Inequality. There is a growing interest in the ways in which biological and socioeconomic heritage can shape vulnerabilities to disease. Once viewed as primarily a product of recent conditions such as lifestyle choices, it is now evident that health outcomes can also be shaped by intergenerational mechanisms. Analysis of these in current populations is impractical given the considerable time it would take for a prospective study to unfold. The analysis of histor ....Intergenerational Transmission of Inequality. There is a growing interest in the ways in which biological and socioeconomic heritage can shape vulnerabilities to disease. Once viewed as primarily a product of recent conditions such as lifestyle choices, it is now evident that health outcomes can also be shaped by intergenerational mechanisms. Analysis of these in current populations is impractical given the considerable time it would take for a prospective study to unfold. The analysis of historical populations, however, presents an opportunity to circumvent this obstacle. Using data for male and female convicts and their descendants, this project seeks to determine the extent to which disadvantage experienced by one generation impacted on the life expectancy of those that followed.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
Program evaluation of the osteoarthritis awareness hub. Persons with osteoarthritis generally have poor knowledge about their disease and its appropriate management. The aim of this project is to evaluate whether improved knowledge, and management decisions of persons with osteoarthritis, can ultimately lead to improved health outcomes.