Discovery Early Career Researcher Award - Grant ID: DE200100825
Funder
Australian Research Council
Funding Amount
$422,955.00
Summary
Functional insights into the roles of enteric glia. This project aims to review our current definition of enteric glia populations, and our understanding of their communication mechanisms in the mouse and primate colon. It will generate new knowledge of enteric glia biology using advanced microscopy and image analysis. Calcium imaging and novel biosensors will measure cell signalling in enteric glia. It will provide the most comprehensive analysis of glia connectivity, morphology and receptor ex ....Functional insights into the roles of enteric glia. This project aims to review our current definition of enteric glia populations, and our understanding of their communication mechanisms in the mouse and primate colon. It will generate new knowledge of enteric glia biology using advanced microscopy and image analysis. Calcium imaging and novel biosensors will measure cell signalling in enteric glia. It will provide the most comprehensive analysis of glia connectivity, morphology and receptor expression in the primate colon. Expected outcomes include a detailed map of enteric glia and definitions of their basic biology. This project builds on the techniques and collaborations made by the candidate over recent years. This will benefit our basic understanding of enteric glia biology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100235
Funder
Australian Research Council
Funding Amount
$422,241.00
Summary
The impact of mass gathering events on emergency healthcare services. Mass gathering events (MGEs) occur frequently across Australia. The preparation of a MGE from an emergency healthcare service perspective is conducted with limited evidence to support decision-making. Using routinely collected data from Tourism and Events Queensland, Queensland Ambulance Service, Queensland Emergency Departments, and the Bureau of Meteorology, this research aims to determine the impact on ambulance and emergen ....The impact of mass gathering events on emergency healthcare services. Mass gathering events (MGEs) occur frequently across Australia. The preparation of a MGE from an emergency healthcare service perspective is conducted with limited evidence to support decision-making. Using routinely collected data from Tourism and Events Queensland, Queensland Ambulance Service, Queensland Emergency Departments, and the Bureau of Meteorology, this research aims to determine the impact on ambulance and emergency department services in the vicinity of 750 planned MGEs over a five year period (2015 - 2019). The expected outcome includes an enhanced ability to predict the required emergency healthcare services for a MGE, therefore enhancing the planning and response, benefiting MGE attendees and the MGE host community.Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less