Body image instability, disordered eating and muscle dysmorphia. Body image is a serious public health issue. Dissatisfaction with body shape promotes disordered eating in females who fast and purge to lose weight, and muscle dysmorphia in males who over-exercise and use steroids to gain muscle. We will test the idea that these psychological disorders stem from an unstable body image. Our research will reveal the fundamental risk factors associated with disordered eating and muscle dysmorphia an ....Body image instability, disordered eating and muscle dysmorphia. Body image is a serious public health issue. Dissatisfaction with body shape promotes disordered eating in females who fast and purge to lose weight, and muscle dysmorphia in males who over-exercise and use steroids to gain muscle. We will test the idea that these psychological disorders stem from an unstable body image. Our research will reveal the fundamental risk factors associated with disordered eating and muscle dysmorphia and allow us to identify at-risk individuals on the basis of their body image instability. It will also predict patients' amenability to treatments that target body image, thereby improving outcomes for these individuals.Read moreRead less
Relative efficacy of self-help treatment for insomnia. This project aims to improve available non-pharmacological treatments for insomnia by determining the relative efficacy of various forms of self-help treatment compared to standard, therapist-led, treatment. Sleep disorders have serious consequences and are widespread. Drug therapies are costly and ineffective and, while psychological treatments have a well-established evidence base, they are not utilised by many. Self-help is a potential ....Relative efficacy of self-help treatment for insomnia. This project aims to improve available non-pharmacological treatments for insomnia by determining the relative efficacy of various forms of self-help treatment compared to standard, therapist-led, treatment. Sleep disorders have serious consequences and are widespread. Drug therapies are costly and ineffective and, while psychological treatments have a well-established evidence base, they are not utilised by many. Self-help is a potential solution, but has not been properly evaluated. This project will determine the efficacy of self-help, the best delivery methods, and should result in more individuals with sleep problems receiving better and cheaper help with benefits for them and society in general.Read moreRead less
The etiology of social anxiety and its impact on development across the lifespan. Social anxiety is a distressing early-onset disorder often associated with other psychiatric conditions in later life. This study will extend our previous work that has identified factors associated with its onset. We propose that these factors and the social anxiety itself may disrupt psychosocial development, at the time of onset, and throughout the lifespan. We aim to investigate these innovative hypotheses thro ....The etiology of social anxiety and its impact on development across the lifespan. Social anxiety is a distressing early-onset disorder often associated with other psychiatric conditions in later life. This study will extend our previous work that has identified factors associated with its onset. We propose that these factors and the social anxiety itself may disrupt psychosocial development, at the time of onset, and throughout the lifespan. We aim to investigate these innovative hypotheses through a sequence of three studies, with adults, children and adolescents. The results will inform prevention and early intervention regimes, thereby reducing both the incidence of social anxiety and the burden of the disorder.Read moreRead less
Patients' preference for participation in patient safety activities. This study will identify patient and nurse perceptions of involving patients in patient safety activities. Priorities for implementing strategies to support patient participation in patient safety activities will be identified, which will influence both health policy and practice.
Prospective predictors of body image attitudes and dieting beliefs during first years of school: Providing guidance for prevention. Although it is recognised that body dissatisfaction is a risk factor for the development of a wide range of mental health problems, little is known about its early development. There is a distinct increase in body dissatisfaction and dieting awareness during early school years. However, there has not been an exploration of a wide range of family, media, peer and sch ....Prospective predictors of body image attitudes and dieting beliefs during first years of school: Providing guidance for prevention. Although it is recognised that body dissatisfaction is a risk factor for the development of a wide range of mental health problems, little is known about its early development. There is a distinct increase in body dissatisfaction and dieting awareness during early school years. However, there has not been an exploration of a wide range of family, media, peer and school adaptation variables as predictors of body image and weight change behaviours in both girls and boys. This project will examine prospective predictors of body image and related variables in five to seven years old children. Findings will inform development of prevention interventions to assist parents and schools provide a positive body image and eating environment for Australian children.Read moreRead less
The critical role of kisspeptin/neurokinin/dynorphin (KNDy) neurons in gonadotropin releasing hormone (GnRH) release. The brain controls fertility through the secretion of its primary stimulatory factor, gonadotropin releasing hormone (GnRH). Brain cells producing three key peptide hormones, kisspeptin, neurokin B and dynorphin (termed KNDy cells) are vital for the control of GnRH. This project will detail the role of KNDy cells in puberty and reproduction.
Genes, neuroanatomy and family process: Predicting adolescent anxiety and depression. Whilst significant gains in outcomes have been obtained in other areas of health by focusing on early intervention and prevention, in the mental health field this approach has been limited by the paucity of developmentally targeted treatment and prevention strategies. This study will provide unique information regarding the risk processes that are operating during early and late adolescence, and will inform us ....Genes, neuroanatomy and family process: Predicting adolescent anxiety and depression. Whilst significant gains in outcomes have been obtained in other areas of health by focusing on early intervention and prevention, in the mental health field this approach has been limited by the paucity of developmentally targeted treatment and prevention strategies. This study will provide unique information regarding the risk processes that are operating during early and late adolescence, and will inform us about how the family environment can act to modulate the impacts of biological vulnerability on risk for mental disorder. This project will contribute to our understanding of who, and what, to target in early intervention and prevention strategies.Read moreRead less
Very young adolescents and substance use: community and family vulnerabilities and healthy developmental transitions. This research will examine how families and communities protect very young children from early alcohol and tobacco use. The findings will lead to new prevention policies and programs that better meet the needs of vulnerable communities. This project will strengthen collaborations with leading international research centres in this area.
Drug Companies, their Patenting Strategies and High-Cost Pharmaceuticals: An Empirical Investigation. Pharmaceuticals are a vital part of clinical services that maintain and improve Australia's health; they are also costly, absorbing a substantial proportion of the national health expenditures. By conferring market protections, the patent system helps the manufacturers of pharmaceuticals to recoup the high costs of research associated with developing new products. Abuses of the patent system by ....Drug Companies, their Patenting Strategies and High-Cost Pharmaceuticals: An Empirical Investigation. Pharmaceuticals are a vital part of clinical services that maintain and improve Australia's health; they are also costly, absorbing a substantial proportion of the national health expenditures. By conferring market protections, the patent system helps the manufacturers of pharmaceuticals to recoup the high costs of research associated with developing new products. Abuses of the patent system by pharmaceutical manufacturers have the potential to stifle competition and inappropriately raise the costs of pharmaceuticals to society. This innovative, cross-disciplinary, research will investigate the existence of abusive patents and, if necessary, propose reforms that will prevent further abuse and reduce the size of the health budget. Read moreRead less
Tumour localisation and enhancement of anthracycline anticancer activity. The anthracyclines are one of the most widely used anticancer agents today. If the cytotoxicity of these agents can be localised to tumour cells, or their activity improved, then this will result in improved response rates, less side-effects and an improved quality of life for many patients for whom anthracycline treatment is an important part of their therapy. This will result in enormous national/community benefit to an ....Tumour localisation and enhancement of anthracycline anticancer activity. The anthracyclines are one of the most widely used anticancer agents today. If the cytotoxicity of these agents can be localised to tumour cells, or their activity improved, then this will result in improved response rates, less side-effects and an improved quality of life for many patients for whom anthracycline treatment is an important part of their therapy. This will result in enormous national/community benefit to an aging Australian population that is becoming increasingly more prone to cancer. Read moreRead less