Discovery Early Career Researcher Award - Grant ID: DE180100261
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Understanding interactions between gut epithelial stem cells and neurons. This project aims to investigate the interaction between gut neurons and the epithelial stem cell compartment, as well as the relationship between age-related loss of enteric neurons and changes in gut epithelial stem cells. This project will include novel co-culturing of organoids and enteric neurospheres, which will identify mechanisms by which nerves influence the epithelia. The outcome of the project will be a better u ....Understanding interactions between gut epithelial stem cells and neurons. This project aims to investigate the interaction between gut neurons and the epithelial stem cell compartment, as well as the relationship between age-related loss of enteric neurons and changes in gut epithelial stem cells. This project will include novel co-culturing of organoids and enteric neurospheres, which will identify mechanisms by which nerves influence the epithelia. The outcome of the project will be a better understanding of the biology of the body’s most highly proliferative, long-lived stem cells, intestinal epithelial stem cells. This could have significant long term impact on the quality of life in an ageing population.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100825
Funder
Australian Research Council
Funding Amount
$422,955.00
Summary
Functional insights into the roles of enteric glia. This project aims to review our current definition of enteric glia populations, and our understanding of their communication mechanisms in the mouse and primate colon. It will generate new knowledge of enteric glia biology using advanced microscopy and image analysis. Calcium imaging and novel biosensors will measure cell signalling in enteric glia. It will provide the most comprehensive analysis of glia connectivity, morphology and receptor ex ....Functional insights into the roles of enteric glia. This project aims to review our current definition of enteric glia populations, and our understanding of their communication mechanisms in the mouse and primate colon. It will generate new knowledge of enteric glia biology using advanced microscopy and image analysis. Calcium imaging and novel biosensors will measure cell signalling in enteric glia. It will provide the most comprehensive analysis of glia connectivity, morphology and receptor expression in the primate colon. Expected outcomes include a detailed map of enteric glia and definitions of their basic biology. This project builds on the techniques and collaborations made by the candidate over recent years. This will benefit our basic understanding of enteric glia biology.Read moreRead less
Improving quality of life in chronic aphasia: reducing depression and increasing social connection and life participation through community aphasia groups. Aphasia, a communication disability resulting from brain injury and experienced by over 80,000 Australians, impacts significantly on social connection, well being and mental health. This program of research defines excellent community aphasia groups, an important preventative health measure and investigates their impact for Australians with a ....Improving quality of life in chronic aphasia: reducing depression and increasing social connection and life participation through community aphasia groups. Aphasia, a communication disability resulting from brain injury and experienced by over 80,000 Australians, impacts significantly on social connection, well being and mental health. This program of research defines excellent community aphasia groups, an important preventative health measure and investigates their impact for Australians with aphasiaRead moreRead less
Communicating with older people across transition points of care. This project aims to examine how health professionals, older people and their family members communicate in managing medications as older people move through transition points of care. Communication problems often occur as older people move between and within settings, often leading to harmful medication incidents. The project expects to facilitate medication safety as older people move across different settings and to facilitate ....Communicating with older people across transition points of care. This project aims to examine how health professionals, older people and their family members communicate in managing medications as older people move through transition points of care. Communication problems often occur as older people move between and within settings, often leading to harmful medication incidents. The project expects to facilitate medication safety as older people move across different settings and to facilitate cultural shifts in health care communication and opportunities for consumer involvement.Read moreRead less
Integrated depression management: a trial of a new model of care in a low vision rehabilitation setting. The project will integrate depression management into Vision Australia services and evaluate the impact of this new model of care. We anticipate that this new approach will lead to sustained improvements in clients’ quality of life.