Innovation In The Synthesis And Translation Of Research Evidence To Inform The Prevention, Management And Treatment Of Chronic Disease In Indigenous Populations
Funder
National Health and Medical Research Council
Funding Amount
$2,642,121.00
Summary
Chronic disease remains the principal cause of health inequality for Indigenous Australians. Primary care is critical to mounting a health system response. The Aboriginal community controlled sector is at the coal face of chronic disease management, yet requires the synthesis, utilisation, development, evaluation and translation of evidence to practice. CREATE was established for this purpose
Which Heart Failure Intervention Is Most Cost Effective In Reducing Hospital Care (WHICH? II) Trial: A Multicentre, Randomised Trial Of Standard Versus Intensified Management Of Metropolitan And Regional-dwelling Patients With Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$1,891,210.00
Summary
Chronic heart failure (CHF) management programs are now the gold-standard to cost-effectively care for thousands of Australians hospitalised with CHF each year. We’ve shown that home-based management is most cost-effective in reducing hospital stay in CHF. The Which Intervention is most Cost-effective in reducing Hospital care (WHICH? II) Trial, a multicentre, randomised study, will determine if more intensive care (via home visits and remote care contacts) further improves poor outcomes in CHF.
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
The cost of keeping gruesome images from the world. This project aims to investigate one of society’s most invisible ‘frontline’ trauma workforces—the online content moderators responsible for limiting the public’s exposure to distressing and sensitive content on social media. Using a series of rigorous experiments, and cutting-edge psychological and physiological assessment techniques, the research will advance our understanding of the impact of indirect trauma on mental health. Expected outcom ....The cost of keeping gruesome images from the world. This project aims to investigate one of society’s most invisible ‘frontline’ trauma workforces—the online content moderators responsible for limiting the public’s exposure to distressing and sensitive content on social media. Using a series of rigorous experiments, and cutting-edge psychological and physiological assessment techniques, the research will advance our understanding of the impact of indirect trauma on mental health. Expected outcomes include novel empirical evidence for preventative strategies that will predict, monitor and reduce negative mental health outcomes. This will provide significant global benefits to people with indirect trauma experiences, such as defence and forensic personnel.Read moreRead less
Evaluation of a Training Program for Staff to Recognize Depression Among Aged People Living in Residential and Community Care. Depression is a significant problem among older people, and is likely to increase in prevalence with the aging of the population. A large percentage of depressed older people fail to receive treatment because their depression is not diagnosed. This illness leads to high economic and social costs if it is not diagnosed and treated. This project will evaluate the effective ....Evaluation of a Training Program for Staff to Recognize Depression Among Aged People Living in Residential and Community Care. Depression is a significant problem among older people, and is likely to increase in prevalence with the aging of the population. A large percentage of depressed older people fail to receive treatment because their depression is not diagnosed. This illness leads to high economic and social costs if it is not diagnosed and treated. This project will evaluate the effectiveness of a training program to assist carers to detect depression, and so refer older people for treatment of this condition. Read moreRead less
Intergenerational transmission of dietary behaviour. The health of future generations depends largely on the health of current generations. Bad eating habits associated with obesity and other chronic diseases are often passed from parents to children. This study will provide insight into the ways in which these habits are perpetuated within families of various cultural backgrounds. It will establish how assessing family health history can be used as a tool to help identify and modify the risk of ....Intergenerational transmission of dietary behaviour. The health of future generations depends largely on the health of current generations. Bad eating habits associated with obesity and other chronic diseases are often passed from parents to children. This study will provide insight into the ways in which these habits are perpetuated within families of various cultural backgrounds. It will establish how assessing family health history can be used as a tool to help identify and modify the risk of chronic, life-threatening disease in families and individuals. If proven effective, this tool can be rolled out nationwide to help promote and maintain healthier diets in Australian families and reduce the economic burden on the government.Read moreRead less
Determination Of Irradiation Dose Efficacy For Use In Impaction Grafting At Revision Joint Replacement
Funder
National Health and Medical Research Council
Funding Amount
$411,517.00
Summary
Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence ....Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence of early complications of this procedure have included loss of fixation within the bone. Fracture of the bone around prostheses has also reported in some centres. These events require more surgery, putting the patient at higher risk greater complications and longer rehabilitations. Recent improvements in surgical technique and donor bone preparation have improved results. A current debate questions whether the dose of irradiation can be reduced from 25 kGy, while maintaining sterility of allografts. The risk of bacterial contamination in allografts is low, and irradiation reduces the mechanical strength of the graft, contributing to complications when irradiated bone is used. The benefits of decontaminating the bone may be outweighed by the higher risk for failure due to poor bone quality and resulting prosthesis instability. We will use ISO standards to test the validity of radiation dose for sterilising bone ex vivo. In the absence of controlled human studies, our aim is also to compare the results of impaction grafting with non-irradiated bone versus bone irradiated at current doses used by Australian bone banks, and lower doses indicated by ex vivo testing. We will use a large animal model of revision hip replacement, with precise measures of prosthesis stability. The results of this study will guide clinical decisions regarding the efficacy of current bone graft preparation procedures and the use of irradiated bone in human hip replacement surgery.Read moreRead less
Identification of Biological pathways regulated by circular RNAs. Circular RNAs (circRNAs) are a, recently discovered molecule. circRNAs are highly abundant and expressed in a tissue and disease specific manner. Yet, currently the understanding of how circRNAs regulate biological processes is very poor. This project aims to use pooled shRNA libraries to screen a large panel of cell lines and systematically identify cellular activities that are regulated by circRNAs. The expected outcome of this ....Identification of Biological pathways regulated by circular RNAs. Circular RNAs (circRNAs) are a, recently discovered molecule. circRNAs are highly abundant and expressed in a tissue and disease specific manner. Yet, currently the understanding of how circRNAs regulate biological processes is very poor. This project aims to use pooled shRNA libraries to screen a large panel of cell lines and systematically identify cellular activities that are regulated by circRNAs. The expected outcome of this study will be a catalogue of functionally active circRNAs. Over the past decades, the wealth of knowledge on the function of linear mRNAs has had a significant impact on medicine and agriculture. Similarly understanding how circRNAs regulate cellular activities may have an analogous impact on humans.Read moreRead less
Strengthening community partnerships to promote adolescent school engagement and prevent problems such as alcohol misuse and violence. The project will reduce community rates of adolescent school non-attendance, adolescent alcohol misuse and antisocial behaviour. Adolescent school exclusion, alcohol use and antisocial behaviour are highly prevalent in Australia, and can be reduced using a variety of strategies that are coordinated at the school and community level. The project will decrease adol ....Strengthening community partnerships to promote adolescent school engagement and prevent problems such as alcohol misuse and violence. The project will reduce community rates of adolescent school non-attendance, adolescent alcohol misuse and antisocial behaviour. Adolescent school exclusion, alcohol use and antisocial behaviour are highly prevalent in Australia, and can be reduced using a variety of strategies that are coordinated at the school and community level. The project will decrease adolescent problems through community improvements in child and adolescent protective influences and reductions in risk influences. Furthermore, the project will equip communities with the capacity to learn how to identify and implement strategies to address the major influences that have the potential to reduce adolescent behaviour problems.Read moreRead less