Regulation of lung immune-epithelial networks sensing environmental change. This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic ....Regulation of lung immune-epithelial networks sensing environmental change. This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic substances. Understanding this molecular program of epithelial-immune cell-mediated sensing/repair will be essential to understand how tissue-repair processes can be driven in the lung, an organ critical for respiration and thus life.Read moreRead less
The production, use and effect of social work research. This project aims to reform social work research to improve the quality and effectiveness of human services. The human services industry is vital to many people’s quality of life, but lacks innovation and struggles to demonstrate its effectiveness. Crucially for social work, research expands thinking about how to respond to social disadvantage. This project intends to examine the scope and quality of Australian social work research in child ....The production, use and effect of social work research. This project aims to reform social work research to improve the quality and effectiveness of human services. The human services industry is vital to many people’s quality of life, but lacks innovation and struggles to demonstrate its effectiveness. Crucially for social work, research expands thinking about how to respond to social disadvantage. This project intends to examine the scope and quality of Australian social work research in child protection, disability services, and aged care; assess the use of this research to the human services sector and its effect on generating innovation; and develop strategies to advance the production, uptake, and effect of social work research.Read moreRead less
Every Day Matters: Reducing School Non-Attendance in Autistic Students. Autistic children miss one day a week of school, three times more than their peers. This significantly impacts their learning, wellbeing and later, their vocational outcomes. This project aims to identify the factors that put autistic children at increased risk of missing school and map the supports and interventions used to reduce school non-attendance. Expected outcomes include an autism-specific model of the how and why s ....Every Day Matters: Reducing School Non-Attendance in Autistic Students. Autistic children miss one day a week of school, three times more than their peers. This significantly impacts their learning, wellbeing and later, their vocational outcomes. This project aims to identify the factors that put autistic children at increased risk of missing school and map the supports and interventions used to reduce school non-attendance. Expected outcomes include an autism-specific model of the how and why school non-attendance is elevated for autistic students. It is anticipated that this model make the important step of enabling teachers and professionals to identify which autistic children are most at risk of absenteeism and select the best strategies to support a positive and beneficial return to school.Read moreRead less
Fostering lifelong connections for children in permanent care. The out-of-home care sector in Australia is undergoing transformation to ensure children who cannot be restored to birth families exit care to permanent families. New South Wales is leading the way on these reforms. The emerging Australian policy model, permanency with lifelong connection to birth families, is distinctly different from the policy models in similar Western nations. While the Australian policy goal is clear, practices ....Fostering lifelong connections for children in permanent care. The out-of-home care sector in Australia is undergoing transformation to ensure children who cannot be restored to birth families exit care to permanent families. New South Wales is leading the way on these reforms. The emerging Australian policy model, permanency with lifelong connection to birth families, is distinctly different from the policy models in similar Western nations. While the Australian policy goal is clear, practices for achieving this goal are under-developed. This action research project will engage the New South Wales out-of-home care sector to design and trial relationship-building practices that promote positive relationships between children and their birth families.Read moreRead less
The role of protein glycosylation in erythropoiesis . This project aims to understand how the sugar code of key-signalling proteins influences the development of red blood cells. This project expects to generate new fundamental knowledge in the area of stem cell signalling by innovative integration of biological and computational molecular characterisation techniques. The expected outcomes of this project include the development of novel workflows to study key regulators of cell development and ....The role of protein glycosylation in erythropoiesis . This project aims to understand how the sugar code of key-signalling proteins influences the development of red blood cells. This project expects to generate new fundamental knowledge in the area of stem cell signalling by innovative integration of biological and computational molecular characterisation techniques. The expected outcomes of this project include the development of novel workflows to study key regulators of cell development and the generation of new knowledge in stem cell signalling that will find applications in transforming stem cell therapies and associated research for future applications such as the laboratory manufacturing of red blood cells to close the availability gap for transfusion purposes.Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less