Development And Implementation Of Evidence-based Deprescribing Guidelines To Guide Person-centred Care For People With Dementia
Funder
National Health and Medical Research Council
Funding Amount
$623,363.00
Summary
Optimising medication use in people with dementia will include both initiation of necessary medications and withdrawal of unnecessary and harmful medications. Many guidelines exist to aid doctors when prescribing medication, however, no guidelines currently exist that detail when, or how to withdraw medications. Development and implementation of such guidelines into practice may lead to improved quality of life of people with dementia and their carers.
A Pilot Dementia Clinical Quality Registry To Improve Dementia Clinical Care
Funder
National Health and Medical Research Council
Funding Amount
$1,571,501.00
Summary
Clinical Quality Registries collect health data about the quality of clinical care and assist the implementation and monitoring of clinical guidelines into practice. Registries can identify variations in clinical care across geographical areas, facilitate further research into a condition, and help refine and develop new guidelines over time. This proposal will test procedures and pilot a clinical quality registry for dementia, using data from a well-characterised cohort.
An integrated platform built on efficient informatics concepts already implemented in international research infrastructures for large-scale data management, providing access to federated databases/registries, biobank catalogues, harmonised - omics profiles, and bioinformatics tools. Patient data types will be linked via a unique identifier “RD-ID” developed jointly with the US NIH. RD-Connect is a primary enabler for IRDiRC funded research to improve treatment and management of rare diseases
OzENTER-TBI_Australia-Europe NeuroTrauma Effectiveness Research In TBI Collaboration
Funder
National Health and Medical Research Council
Funding Amount
$368,823.00
Summary
The OzENTER-TBI project will advance the care of traumatic brain injury (TBI) patients. Researchers will collaborate with the European CENTER-TBI project to characterise and classify TBI. They will contribute to large data sets which will explore the differences between sites and countries on TBI outcomes. They will also investigate emerging technologies in TBI. It will have a profound impact on treatment, health care costs and ultimately quality of life for TBI patients worldwide.
Application Of Omics-based Strategies For Improved Diagnosis And Treatment Of Endocrine Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$461,322.00
Summary
Arterial hypertension affects up to 45% of the general population and is responsible for 7.1 million deaths per year worldwide. We will define specific omics profiles for patients with a range of hypertension-related disorders by integrating high throughput genetics, genomics and metabolomics data. This should allow identification of patients with preclinical phenotypes along with those hypertensives that cluster into specific endocrine groups who may benefit from personalised treatment.
Spatial Learning And Memory In Huntington's Disease
Funder
National Health and Medical Research Council
Funding Amount
$475,969.00
Summary
This project will develop a spatial learning and memory test battery sensitive to dementia in Huntington’s disease, relate the task to atrophy in key brain regions, and then apply the test in a clinical trial aimed at developing a regeneration of damaged brain regions in Huntington’s disease. The overarching goal is to develop a cognitive test that is closely aligned to brain pathology in dementia as a tool for more precise, mechanism-based investigations in the dementia clinical trial setting.
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
The Interaction Between The Host And Pathogen Genetics In Susceptibility To Pulmonary Tuberculosis
Funder
National Health and Medical Research Council
Funding Amount
$390,294.00
Summary
People infected with the bacteria causing tuberculosis (TB) have different clinical fates. Some people remain well with dormant infections, some get lung disease and survive, others die. We are investigating the interplay between the human host and the bacteria causing disease by identifying genetic variants in both. This will enable us to determine what is important in the defence against this disease. Knowledge of the different TB disease processes is critical for future rational design of new ....People infected with the bacteria causing tuberculosis (TB) have different clinical fates. Some people remain well with dormant infections, some get lung disease and survive, others die. We are investigating the interplay between the human host and the bacteria causing disease by identifying genetic variants in both. This will enable us to determine what is important in the defence against this disease. Knowledge of the different TB disease processes is critical for future rational design of new TB vaccines and treatments.Read moreRead less
Randomised Controlled Trial Of Early Use Of A Simplified Treatment Regimen Incorporating A Half-dose, Three-in-one Blood Pressure Lowering Pill Vs. Usual Care For Improving Hypertension Control In India.
Funder
National Health and Medical Research Council
Funding Amount
$1,095,201.00
Summary
Hypertension affects a large proportion of the Indian population. Effective medications exist to lower blood pressure (BP) and the adverse effects of hypertension. However, complex medication regimes and the need to take multiple drugs can affect patient adherence to drugs, making it difficult to achieve good BP control. This research will investigate whether use of a simplified treatment protocol including a three-in-one BP lowering pill can improve BP control in Indians with hypertension.
Developing A Sustainable Community Based Response To Asbestos-related Diseases In Aboriginal Communities
Funder
National Health and Medical Research Council
Funding Amount
$623,155.00
Summary
Asbestos-related disease in remote Aboriginal communities where asbestos mining has occurred over many decades is an under-recognised problem. In contrast to many occupationally-exposed groups, little is known or published on the burden of disease affecting these communities and health program responses based on good science are underdeveloped. This project will support two Aboriginal community-controlled primary health care services to: estimate the number of people affected in local communitie ....Asbestos-related disease in remote Aboriginal communities where asbestos mining has occurred over many decades is an under-recognised problem. In contrast to many occupationally-exposed groups, little is known or published on the burden of disease affecting these communities and health program responses based on good science are underdeveloped. This project will support two Aboriginal community-controlled primary health care services to: estimate the number of people affected in local communities; find the best way to diagnose and manage lung and asbestos disease and prevent complications; advocate for affected individuals, families and communities. Rather than the usual 'in-out' health survey, this research project will build the capacity of local communities and health service to implement and sustain holistic responses.Read moreRead less