Regulation of lung immune-epithelial networks sensing environmental change. This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic ....Regulation of lung immune-epithelial networks sensing environmental change. This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic substances. Understanding this molecular program of epithelial-immune cell-mediated sensing/repair will be essential to understand how tissue-repair processes can be driven in the lung, an organ critical for respiration and thus life.Read moreRead less
The social and cognitive functions of affect. Dealing with affective problems represents a major challenge in clinical, health, organisational and counselling psychology. Yet the role that affective states play in thinking, judgments and many everyday social behaviours remains poorly understood.. This project will produce direct national and community benefit by developing a new, integrative theory of affective influences on thinking and action, and exploring the functions and processing consequ ....The social and cognitive functions of affect. Dealing with affective problems represents a major challenge in clinical, health, organisational and counselling psychology. Yet the role that affective states play in thinking, judgments and many everyday social behaviours remains poorly understood.. This project will produce direct national and community benefit by developing a new, integrative theory of affective influences on thinking and action, and exploring the functions and processing consequences of affect in everyday settings. The real-life consequences of affect infusion in applied areas will also be explored. The project will also contribute to Australia's research capability by training doctoral and postdoctoral students, and fostering international research collaboration.Read moreRead less
The stress of obesity stigma: Testing a model of risk and resilience. This project seeks to advance theoretical knowledge about obesity stigma (and stigma more generally), and also to provide novel insights into ways to help obese people cope with stigma. Obese people frequently experience stigma in their everyday lives, but little is known about why, when, and for whom obesity stigma is likely to have the most negative consequences. The aim of this project is to use sophisticated methodological ....The stress of obesity stigma: Testing a model of risk and resilience. This project seeks to advance theoretical knowledge about obesity stigma (and stigma more generally), and also to provide novel insights into ways to help obese people cope with stigma. Obese people frequently experience stigma in their everyday lives, but little is known about why, when, and for whom obesity stigma is likely to have the most negative consequences. The aim of this project is to use sophisticated methodological approaches to test a model of risk and resilience related to obesity stigma which predicts that characteristics of the person (such as past experiences with stigma) and characteristics of the situation (such as who the perpetrator is) determine how people respond to stigmatising experiences. The model tested in this project may help identify ways to reduce the negative impact of obesity stigma, which would have important social and health benefits.Read moreRead less
The dynamics of viral latency in chronic infection. Although many acute infections can now be controlled, we still suffer from a large number of chronic infections such as HIV or herpes that cannot be eradicated. Many of these infections persist because they can lie dormant in a 'latent' state. How this latent state is established, and how long it lasts are important to understand if we want to control these infections. We have assembled a team of mathematicians, immunologists and virologists in ....The dynamics of viral latency in chronic infection. Although many acute infections can now be controlled, we still suffer from a large number of chronic infections such as HIV or herpes that cannot be eradicated. Many of these infections persist because they can lie dormant in a 'latent' state. How this latent state is established, and how long it lasts are important to understand if we want to control these infections. We have assembled a team of mathematicians, immunologists and virologists in order to study latent infection at the cellular level, and within infected monkeys. This will provide the first insights into the dynamics of latency - how these cells are produced and die - and should lead to novel approaches to controlling chronic infection.Read moreRead less
The production, use and effect of social work research. This project aims to reform social work research to improve the quality and effectiveness of human services. The human services industry is vital to many people’s quality of life, but lacks innovation and struggles to demonstrate its effectiveness. Crucially for social work, research expands thinking about how to respond to social disadvantage. This project intends to examine the scope and quality of Australian social work research in child ....The production, use and effect of social work research. This project aims to reform social work research to improve the quality and effectiveness of human services. The human services industry is vital to many people’s quality of life, but lacks innovation and struggles to demonstrate its effectiveness. Crucially for social work, research expands thinking about how to respond to social disadvantage. This project intends to examine the scope and quality of Australian social work research in child protection, disability services, and aged care; assess the use of this research to the human services sector and its effect on generating innovation; and develop strategies to advance the production, uptake, and effect of social work research.Read moreRead less
Non-medical use of prescription stimulants by Australian university students: attitudes, prevalence of, and motivations for use. This study will provide a comprehensive understanding of student non-medical use of prescription stimulants. The findings will inform initiatives to prevent the abuse and misuse of pharmaceuticals, protect health and reduce the cost associated with inappropriate use of medicines.
The Power of Causal Attributions: Genetic Essentialist Biases and Health. Great advancements in the science of genetics are accompanied by increased public propensity to attribute causality to the genes for diverse outcomes such as abilities, social group differences, attitudes, and diseases. These genetic attributions activate cognitive biases termed Genetic Essentialist Biases, which have been shown to instigate a variety of deleterious outcomes. The project will evaluate hypothesized detrimen ....The Power of Causal Attributions: Genetic Essentialist Biases and Health. Great advancements in the science of genetics are accompanied by increased public propensity to attribute causality to the genes for diverse outcomes such as abilities, social group differences, attitudes, and diseases. These genetic attributions activate cognitive biases termed Genetic Essentialist Biases, which have been shown to instigate a variety of deleterious outcomes. The project will evaluate hypothesized detrimental effects of genetic attributions on actual health behaviours, endorsement of health policies, and disease related stigma. Furthermore, it will test interventions designed to reduce the negative effects of such attributions on attitudes, beliefs, intentions, and behaviours related to a common disease. Read moreRead less
Program evaluation of the osteoarthritis awareness hub. Persons with osteoarthritis generally have poor knowledge about their disease and its appropriate management. The aim of this project is to evaluate whether improved knowledge, and management decisions of persons with osteoarthritis, can ultimately lead to improved health outcomes.
Every Day Matters: Reducing School Non-Attendance in Autistic Students. Autistic children miss one day a week of school, three times more than their peers. This significantly impacts their learning, wellbeing and later, their vocational outcomes. This project aims to identify the factors that put autistic children at increased risk of missing school and map the supports and interventions used to reduce school non-attendance. Expected outcomes include an autism-specific model of the how and why s ....Every Day Matters: Reducing School Non-Attendance in Autistic Students. Autistic children miss one day a week of school, three times more than their peers. This significantly impacts their learning, wellbeing and later, their vocational outcomes. This project aims to identify the factors that put autistic children at increased risk of missing school and map the supports and interventions used to reduce school non-attendance. Expected outcomes include an autism-specific model of the how and why school non-attendance is elevated for autistic students. It is anticipated that this model make the important step of enabling teachers and professionals to identify which autistic children are most at risk of absenteeism and select the best strategies to support a positive and beneficial return to school.Read moreRead less
Cross-linked Tyrosine Residues in Peptides and Proteins. Many peptides and proteins have recently been found to contain unusual structural modifications, commonly in the form of cross-linked tyrosine residues. The aims of this project are to design and synthesise examples of these cross-linked tyrosine structures, thereby enabling the preparation of models of the modified proteins. Outcomes of this research will include an increased understanding of the relationship between the three-dimensional ....Cross-linked Tyrosine Residues in Peptides and Proteins. Many peptides and proteins have recently been found to contain unusual structural modifications, commonly in the form of cross-linked tyrosine residues. The aims of this project are to design and synthesise examples of these cross-linked tyrosine structures, thereby enabling the preparation of models of the modified proteins. Outcomes of this research will include an increased understanding of the relationship between the three-dimensional structure and biological activity of peptides/proteins, the generation of lead compounds for new anti-bacterial and anti-fungal pharmaceuticals, and the preparation of biological 'markers' of the processes involved in neurodegenerative diseases and aging.Read moreRead less