A Randomized Comparison Evaluating The Value Of High-sensitivity Troponin In The Efficient Management Of Chest Pain Patients Across The Spectrum Of Risk For An Acute Coronary Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$508,567.00
Summary
Chest pain patients are a large burden of emergency department demand. Their effective care requires timely risk assessment. High-sensitivity assays for cardiac muscle damage (troponin) increases the ability to detect patients with heart attacks, but may also lead to more abnormal results from other causes and more admissions. This randomized trial of current troponin versus a new troponin assays with robust initial evaluation of patient risk will provide a rationale for their use in modern care ....Chest pain patients are a large burden of emergency department demand. Their effective care requires timely risk assessment. High-sensitivity assays for cardiac muscle damage (troponin) increases the ability to detect patients with heart attacks, but may also lead to more abnormal results from other causes and more admissions. This randomized trial of current troponin versus a new troponin assays with robust initial evaluation of patient risk will provide a rationale for their use in modern care.Read moreRead less
Targeted LOWering Of Central Blood Pressure In Patients With Hypertension: A Randomised Controlled Trial (LOW CBP Study)
Funder
National Health and Medical Research Council
Funding Amount
$1,442,405.00
Summary
For over 100 years doctors have measured blood pressure (BP) using a cuff at the upper arm. However, this method has many drawbacks that can result in inappropriate treatment decisions. New technology has emerged to measure central BP, which allows a more accurate BP assessment and may improve patient care. This study will test the clinical value of this new measure of central BP. Findings are expected to lead to a change in the way that people with high BP are diagnosed and managed by doctors.
Which Heart Failure Intervention Is Most Cost Effective In Reducing Hospital Care (WHICH? II) Trial: A Multicentre, Randomised Trial Of Standard Versus Intensified Management Of Metropolitan And Regional-dwelling Patients With Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$1,891,210.00
Summary
Chronic heart failure (CHF) management programs are now the gold-standard to cost-effectively care for thousands of Australians hospitalised with CHF each year. We’ve shown that home-based management is most cost-effective in reducing hospital stay in CHF. The Which Intervention is most Cost-effective in reducing Hospital care (WHICH? II) Trial, a multicentre, randomised study, will determine if more intensive care (via home visits and remote care contacts) further improves poor outcomes in CHF.
Diabetes and heart disease are major causes of premature death, disability and high health care costs in Australia. Better strategies for the prevention and treatment of these conditions are needed. Professor Keech will continue to design and lead clinical trials and related laboratory research to evaluate and develop strategies to improve the lives of people with or at high risk of these conditions. He will also mentor the next generation of researchers.
Central Blood Pressure: Physiology And Clinical Application
Funder
National Health and Medical Research Council
Funding Amount
$459,270.00
Summary
Current methods used by doctors to measure blood pressure (BP) have many limitations that could result in incorrect diagnosis and inappropriate treatment of high BP (hypertension). This research program will determine the clinical usefulness of new methods to diagnose and treat people with high BP. The underlying mechanisms contributing to high BP will also be examined. The findings will lead to improved ways to identify and more effectively manage people with high BP.
Triple Therapy Prevention Of Recurrent Intracerebral Disease EveNts Trial (TRIDENT)
Funder
National Health and Medical Research Council
Funding Amount
$5,256,292.00
Summary
Acute intracerebral haemorrhage (ICH) is a serious form of stroke. Survivors of ICH are at high risk of repeat events. Blood pressure lowering is a very important to prevent repeat events but data shows blood pressure is poorly controlled in these patients. In this research we investigate whether an approach that uses a 'triple pill' strategy (3 low dose BP drugs in one pill) in ICH patients with mild to moderate hypertension can decrease major cardiovascular events.
Molecular And Structural Determinants Of Myocardial Dysfunction And Prognosis In Left And Right Heart Failure.
Funder
National Health and Medical Research Council
Funding Amount
$124,608.00
Summary
The aim of this research is to investigate the role of inherited genetic variation on myocardial function and prognosis in patients with cardiomyopathies as well as pulmonary hypertension. Clinical, cardiac genomic and myocardial tissue studies will be undertaken in various patient cohorts. It is hoped that this research will provide new insights into disease mechanisms, and will contribute to new approaches to patient management and risk stratification.
Application Of Genomic Technologies For The Diagnosis And Management Of Genetic Heart Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$438,768.00
Summary
The purpose of this research study is to investigate clinical and genetic factors which may predispose to important cardiac events such as dangerous arrhythmias, heart failure, heart transplantation or sudden cardiac death in patients with genetic heart diseases. It is possible that there are important risk factors or genetic findings which may be identified either through newer technologies which help cardiologists determine which patients and families are most at risk.
Improving Outcomes In Heart Failure Through Basic, Clinical And Translational Research
Funder
National Health and Medical Research Council
Funding Amount
$951,005.00
Summary
Heart failure (HF) is a common, chronic cardiovascular condition characterised by a reduced capacity of the heart to function. Patients with HF have a poor quality of life and significantly reduced survival. My proposed programme of research will improve the understanding of heart failure (HF) and lead to better treatments.
Improving The Prevention, Treatment And Management Of Cardiovascular & Chronic Disease In The Community
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
The identification, prevention and management of cardiovascular and chronic disease risk factors and understanding impact on clinical outcomes is fundamental to improving health and well-being. The program of work encapsulated in this application utilises modern epidemiological research methods involving large scale clinical trials, registries and epidemiological modelling to advance our understanding and provide new directions for cardiovascular disease prevention and management.