Ultrathin Gold Nanocrystal Conductors for Wearable Epidermal Biofuel Cells. This project aims to fabricate ultrathin, soft yet stretchable gold nanocrystal conductors to push the thickness limit of next-generation soft bioelectrodes for fabrication of wearable epidermal biofuel cells. This will generate new knowledge and patentable technologies related to design/fabrication of soft nanocrystal conductors, bioanode and biocathode, which require to be thin, soft, conductive and biocompatible. Expe ....Ultrathin Gold Nanocrystal Conductors for Wearable Epidermal Biofuel Cells. This project aims to fabricate ultrathin, soft yet stretchable gold nanocrystal conductors to push the thickness limit of next-generation soft bioelectrodes for fabrication of wearable epidermal biofuel cells. This will generate new knowledge and patentable technologies related to design/fabrication of soft nanocrystal conductors, bioanode and biocathode, which require to be thin, soft, conductive and biocompatible. Expected outcomes of this project include enhanced national capacity in disruptive wearable bioelectronics, strengthening international collaborations, unskilled workforce training, as well as advancement of Australian knowledge base in the fields of nanotechnology, materials science, energy, biosensors and bioelectronics.Read moreRead less
Tissue Bio-physicochemical Quantification Using Magnetic Resonance Imaging. This project aims to develop novel magnetic resonance imaging methods to investigate tissue structure and function. Current MRI technologies use standard water-based contrast mechanisms to generate images with limited tissue information. In contrast, this project expects to provide a non-invasive, ultra-high-resolution MRI technology that measures the electrical, magnetic, and chemical signals generated from the human bo ....Tissue Bio-physicochemical Quantification Using Magnetic Resonance Imaging. This project aims to develop novel magnetic resonance imaging methods to investigate tissue structure and function. Current MRI technologies use standard water-based contrast mechanisms to generate images with limited tissue information. In contrast, this project expects to provide a non-invasive, ultra-high-resolution MRI technology that measures the electrical, magnetic, and chemical signals generated from the human body. Thus, the new imaging methods can probe deeper biological functionality while examining tissue structure. The potential benefits include: expanding the scope and capabilities of current MRI, facilitating a wide range of imaging-based research and applications, and accelerating knowledge expansion in life science.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
Engineering nanoscale tools for cellular interrogation. The aim is to address fundamental hurdles to engineering seamless nanobiointerfaces between electroactive nanoscale tools and living cells. This is expected to allow efficient delivery of many bioactive cargo types into cells, intracellular sampling of cytosol contents, and probing of action potential, all at the cell—material interface. New, powerful, electroactive nanoscale tools that deliver precise spatio-temporal resolution and minimal ....Engineering nanoscale tools for cellular interrogation. The aim is to address fundamental hurdles to engineering seamless nanobiointerfaces between electroactive nanoscale tools and living cells. This is expected to allow efficient delivery of many bioactive cargo types into cells, intracellular sampling of cytosol contents, and probing of action potential, all at the cell—material interface. New, powerful, electroactive nanoscale tools that deliver precise spatio-temporal resolution and minimal invasiveness and perturbation are likely to transform ex-vivo cellular processes. The intended outcomes are crucial for maximising precision in engineering and implementing of ex-vivo cellular processes. Fundamental advances in knowledge may eventually be a platform for developing cell-based therapies.
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Next-generation methods for transport in poroelastic media with interfaces. Deformable porous structures are ubiquitous in the design of materials such as filters, sponges, and prosthetics. They often show complex mechano-chemical processes that occur across several spatio-temporal scales. To mathematically describe them requires coupled sets of nonlinear, multiphysical, and multiscale equations. This makes the design of accurate, efficient numerical methods challenging. The Fellowship aims to a ....Next-generation methods for transport in poroelastic media with interfaces. Deformable porous structures are ubiquitous in the design of materials such as filters, sponges, and prosthetics. They often show complex mechano-chemical processes that occur across several spatio-temporal scales. To mathematically describe them requires coupled sets of nonlinear, multiphysical, and multiscale equations. This makes the design of accurate, efficient numerical methods challenging. The Fellowship aims to address the mathematical characteristics encountered in poromechanics equations and their discretisation methods, and to devise novel mathematical and computational techniques for extending the analysis to cases where large deformations and the presence of interfaces and coupling with other neighbouring elements are relevant.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL220100185
Funder
Australian Research Council
Funding Amount
$3,269,608.00
Summary
Nanostructured Silicon-Based Wearable and Implantable Biosensors. The aim is to gain a deep understanding of the interface between nanostructured-silicon-based nanomaterials and biological systems, to develop a new generation of biosensor technologies applied on and in the body. Using innovative nanofabrication techniques, the team will integrate porous silicon nanomaterials with highly controllable optical and electrochemical properties into wearable and implantable biosensors for detecting bio ....Nanostructured Silicon-Based Wearable and Implantable Biosensors. The aim is to gain a deep understanding of the interface between nanostructured-silicon-based nanomaterials and biological systems, to develop a new generation of biosensor technologies applied on and in the body. Using innovative nanofabrication techniques, the team will integrate porous silicon nanomaterials with highly controllable optical and electrochemical properties into wearable and implantable biosensors for detecting bioanalytes directly and continuously in interstitial fluid, sweat, and blood; critically, they will be capable of long-term monitoring. The outcomes are expected to enable development of downstream applications across medical diagnostics, sports sciences, workplace testing as well as defence and space technologies.Read moreRead less
Identifying how cortical bone microstructure deteriorates with age. This project aims to define the disruptions responsible for the gradual weakening of the skeleton in ageing by integrating a range of high-resolution imaging, biomechanical, and computational methods. The expected significance of this project includes a full definition and comparison of the cellular and subcellular organisation of bone from young and elderly individuals. Expected outcomes of this international project include th ....Identifying how cortical bone microstructure deteriorates with age. This project aims to define the disruptions responsible for the gradual weakening of the skeleton in ageing by integrating a range of high-resolution imaging, biomechanical, and computational methods. The expected significance of this project includes a full definition and comparison of the cellular and subcellular organisation of bone from young and elderly individuals. Expected outcomes of this international project include the establishment of a new multidisciplinary research team, and the development of a new data-driven theoretical framework for understanding the nature and the causes of age-related bone fragility. Potential long-term benefits include new ways to treat age-related osteoporosis.Read moreRead less