Postgraduate Training And Teaching Methodologies In Regional Anaesthesia
Funder
National Health and Medical Research Council
Funding Amount
$130,601.00
Summary
An important skill of specialist anaesthetists is performing nerve blocks to provide excellent pain relief in surgery and childbirth. This PhD research examines the use of new methods of education, including structured assessment, simulation, and high fidelity models to help train the next generation of anaesthetists. The goals of this research is to provide better quality patient care and improve patient outcomes after anaesthesia and surgery.
A Randomised Control Trial Evaluating Outcomes Of An Emergency Nurse Practitioner Service.
Funder
National Health and Medical Research Council
Funding Amount
$83,149.00
Summary
This proposed research will provide much needed evidence on this reform model. Health services research struggles to establish an inquiry context that is flexible to study service-level interventions using the gold standard of a randomised controlled trail (RCT). This proposed research will be conducted in a health service environment with a stable E-NP service innovation and capacity to randomise patient participants.
Development Of A Transdiagnostic Intervention For Patients With Cancer Experiencing Anxiety In The Context Of Ongoing Uncertainty
Funder
National Health and Medical Research Council
Funding Amount
$72,768.00
Summary
Surprisingly little work has been done to explain how anxiety develops and persists in patients with cancer. A model was recently developed to explain how fears of cancer recurrence develop and persist, which led to a new intervention. This study proposes to extend that work for patients with ongoing cancer threat or poor prognosis. The proposed study will develop a model of cancer-related anxiety and develop and test an intervention for anxiety in cancer patients with ongoing uncertainty.
Enhancer RNAs As Cancer Drivers And Predictive Biomarkers Of BET Inhibitor Therapy
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
BET inhibitors are a new type of therapy designed to slow down cancer growth by switching off cancer genes. In individuals with colon and prostate cancer, BET inhibitors have shown good initial results, but these are not long-lasting. By measuring blood levels of a specific type of RNA (a close companion of DNA), called CCAT1 and PCAT1, we hope to better understand which patients gain the most benefit from BET inhibitors, and the mechanisms that cause BET inhibitors to stop working.
Molecular And Structural Determinants Of Myocardial Dysfunction And Prognosis In Left And Right Heart Failure.
Funder
National Health and Medical Research Council
Funding Amount
$124,608.00
Summary
The aim of this research is to investigate the role of inherited genetic variation on myocardial function and prognosis in patients with cardiomyopathies as well as pulmonary hypertension. Clinical, cardiac genomic and myocardial tissue studies will be undertaken in various patient cohorts. It is hoped that this research will provide new insights into disease mechanisms, and will contribute to new approaches to patient management and risk stratification.
Optimising Cooperative Group Cancer Clinical Trials In The Era Of Molecularly Targeted Treatments
Funder
National Health and Medical Research Council
Funding Amount
$55,778.00
Summary
Cancer treatments are tested in trials to ensure that they are effective and safe for use. Recently treatments have been developed that act on newly discovered pathways of cancer growth. I aim to research the way cancer clinical trials are designed and evaluate ways to improve them. This will help to ensure cancer medicines are brought into clinical use as efficiently as possible in this new era of drug treatment.
Improving The Treatment Of Neonatal Sepsis Through Vancomycin Pharmacokinetic And Pharmacodynamic Modelling
Funder
National Health and Medical Research Council
Funding Amount
$71,458.00
Summary
Our study will assess whether vancomycin, a key antibiotic used to treat severe infections in young infants, is best given as a continuous infusion or as multiple doses per day. We will determine which is the most effective method to achieve the target blood level of vancomycin and if current recommended target levels for vancomycin are appropriate for infants. Findings will be used to develop a bedside tool that will enable clinicians to tailor the dose of vancomycin to individual children.
Strategies To Reduce The Burden Of Gastroenteritis In Aboriginal Children.
Funder
National Health and Medical Research Council
Funding Amount
$124,676.00
Summary
Rotavirus is the leading cause of severe gastroenteritis in children. Despite early promise, vaccines which target rotavirus seem to be less effective in low-resource settings and also amongst Australian Indigenous children. This study seeks to assess whether an extra dose of rotavirus vaccine (RV1) will improve the effectiveness of rotavirus vaccine in Aboriginal children and result in decreased admissions and clinic visits in the first three years of life.
Characterisation Of Autoreactive T Cells In Chronic Idiopathic Urticaria Would Improve Its Diagnosis And Treatment.
Funder
National Health and Medical Research Council
Funding Amount
$97,182.00
Summary
Chronic idiopathic urticaria (CIU) is a disease in which itchy hives recur due to no apparent trigger. It is an autoimmune disease in which the immune system reacts against certain cells in the skin, called mast cells and basophils. It is unclear how this occurs. Once activated, mast cells and basophils release a chemical called histamine, which is responsible for the rash. I aim to identify the immune reactions that occur in CIU, develop reliable tests for diagnosis and improve treatment of CIU ....Chronic idiopathic urticaria (CIU) is a disease in which itchy hives recur due to no apparent trigger. It is an autoimmune disease in which the immune system reacts against certain cells in the skin, called mast cells and basophils. It is unclear how this occurs. Once activated, mast cells and basophils release a chemical called histamine, which is responsible for the rash. I aim to identify the immune reactions that occur in CIU, develop reliable tests for diagnosis and improve treatment of CIU.Read moreRead less
Peritoneal Metastases From Colorectal Carcinoma: Exploring The Potential Of Immunotherapy As A Treatment Adjunct
Funder
National Health and Medical Research Council
Funding Amount
$89,197.00
Summary
Twenty percent of patients with bowel cancer have disease involving the lining of the abdomen, called the peritoneum. These patients do poorly. The majority are inoperable, and chemotherapy has poor response in these patients. Therefore, there is a dire need to explore new treatments. Newer drugs that stimulate the immune cells to fight cancer have shown promise in other cancers. We aim to assess the potential of this treatment in peritoneal disease, with the aim of improving patient outcomes.