Adaptive Immunity To Non-typeable H. Influenzae In Children With Bronchiectasis
Funder
National Health and Medical Research Council
Funding Amount
$81,143.00
Summary
Bronchiectasis is a chronic disease of the lungs which affects at least 1 in 68 NT Indigenous children. It causes recurring lung infections, hospitalisations and deteriorating lung function. This study will provide important data on the immune response of Indigenous children to NTHi, the most important pathogen associated with chronic respiratory infections and why this immune response is not protective. This is the first step in targeting therapies to the prevention of bronchiectasis.
A Multi-centre, Double-blind, Randomised Controlled Trial To Evaluate The Efficacy Of 10 Valent-pneumococcal-Protein D Conjugate Vaccine In Reducing Respiratory Exacerbations In Children Aged ? 18 Months With Suppurative Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,160,660.00
Summary
Chronic suppurative (ie infected) lung diseases in children are major causes of poor health and deaths worldwide. Repeated childhood infections contribute to poor lung health in adults. The most common organism causing infection is non-typeable Haemophilus influenzae (NTHi). This study aims to determine whether a vaccine against NTHi can reduce repeated respiratory infections in children. If so, vaccination may lead to substantial improvements in current/ future lung health, and considerable dir ....Chronic suppurative (ie infected) lung diseases in children are major causes of poor health and deaths worldwide. Repeated childhood infections contribute to poor lung health in adults. The most common organism causing infection is non-typeable Haemophilus influenzae (NTHi). This study aims to determine whether a vaccine against NTHi can reduce repeated respiratory infections in children. If so, vaccination may lead to substantial improvements in current/ future lung health, and considerable direct and indirect cost of disease savings.Read moreRead less
Culture-independent Assessment Of The Microbiota Underlying Chronic Suppurative Lung Disease In Indigenous Children.
Funder
National Health and Medical Research Council
Funding Amount
$310,071.00
Summary
Chronic suppurative lung disease (CSLD) affects 1 in 68 Indigenous children in the Northern Territory. The condition leads to loss of lung function which reduces life-expectancy. Little is known about microbial factors underlying the disease. My research uses DNA-based methods to describe lower airway microbiology of CSLD affecting Indigenous children, including investigation of bacteria, viruses and biofilm. Better understanding of the microbiology will potentially lead to development of improv ....Chronic suppurative lung disease (CSLD) affects 1 in 68 Indigenous children in the Northern Territory. The condition leads to loss of lung function which reduces life-expectancy. Little is known about microbial factors underlying the disease. My research uses DNA-based methods to describe lower airway microbiology of CSLD affecting Indigenous children, including investigation of bacteria, viruses and biofilm. Better understanding of the microbiology will potentially lead to development of improved treatments.Read moreRead less
Molecular Public Health In Australian Indigenous Communities And Developing Countries In Our Region To Improve Ear And Respiratory Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
Prevention of pneumonia and ear disease is of global importance. This study aims to improve outcomes for children living in remote Indigenous communities and Developing countries in our Region. Vaccines and antibiotics are powerful health tools, but often fail in high-risk populations for these diseases. Technological advances allow us to better examine the causes of pneumonia and ear disease and measure effects of vaccines and antibiotics. This will allow us to design improved interventions.
Advancing The Knowledge, Understanding And Management Of Respiratory Exacerbations In Children With Bronchiectasis
Funder
National Health and Medical Research Council
Funding Amount
$71,359.00
Summary
Bronchiectasis is a condition which causes significant morbidity, burden of disease and mortality in children as well as adults. Exacerbations in bronchiectasis influence the decline in lung function and quality of life for patients. Although the importance of treating exacerbations effectively is well accepted, there are no universally accepted guidelines for recognizing and managing an exacerbation of bronchiectasis in children. This study aims to fill this clinical and research gap.
Is Long Term Weekly Azithromycin Use For Bronchiectasis In Indigenous Children Associated With Antibiotic Resistance?
Funder
National Health and Medical Research Council
Funding Amount
$398,663.00
Summary
Aboriginal children living in remote areas such as central Australia experience unacceptably high rates of respiratory infection which can become chronic. A randomised controlled trial is being conducted to see if long-term azithromycin therapy reduces respiratory exacerbations in Aboriginal children with chronic lung disease. Concerns about the development of antibiotic resistance need to be addressed. This project aims to determine if such treatment is associated with antibiotic resistance.
Progression Of Kidney Damage In Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$782,249.00
Summary
There is an overwhelming burden of chronic disease in Indigenous Australians. In order to attempt to improve kidney disease in this high-risk population, it is vital that we understand what factors contribute to rapid progression of kidney damage. This study will provide the evidence to design an intervention to slow progression of kidney disease in Indigenous Australians. It will also enable development of appropriate clinical guidelines for improved management of kidney disease.