Rapid mapping of genes for complex traits. This project will develop a new resource that will allow rapid identification of genes controlling complex traits. This world-leading resource will improve knowledge of diseases like diabetes and neurological diseases.
Vaporization of heavier gas oil in Fluid Catalytic Cracking risers. Fluid Catalytic Cracking (FCC) is an important refinery operation responsible for about 45 per cent of the total petrol produced. The project is aimed at improving production efficiency of Australian refineries by applying fundamental modelling to the FCC. The outcomes will enable refiners to produce cleaner fuel and decrease greenhouse gas emissions.
Identifying the diversity and evolution of loci associated with adaptation to aridity/heat and salinity in ancient cereal crops. This project will use ancient grains of wheat, barley and rye to find 'lost' genetic diversity at key genes associated with resistance to aridity, salt and disease. This project will make the proteins of key genes, and study their interaction with the environment over time by measuring ions in the grains to reveal the ancient environmental conditions.
Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization ....Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization tools and numerical models. The final outcome of the project will be a set of designs of the columns, which should be more efficient, safer and cheaper to operate, and have smaller physical and environmental footprints, thus helping the Australian LNG industry to stay globally competitive.Read moreRead less
Energetics and dynamics of solvated biologically relevant molecules using liquid microjet and ion imaging technologies. The shape of many biomolecules in solution plays a critical role in determining their biological activity and function. It is known that the bonds that form between the biomolecules and the water solvent control this shape. However, very little is known about the strength and structure of these bonds at different sites around the biomolecule. Many experiments have informed u ....Energetics and dynamics of solvated biologically relevant molecules using liquid microjet and ion imaging technologies. The shape of many biomolecules in solution plays a critical role in determining their biological activity and function. It is known that the bonds that form between the biomolecules and the water solvent control this shape. However, very little is known about the strength and structure of these bonds at different sites around the biomolecule. Many experiments have informed us about the strength of the bonds, others have told us where the bonds occur. This project will provide both pieces of information for the first time, allowing us to better understand, and therefore control, biological function. This work will assist in the development of new biotechnology processes, especially in the emerging area of proteomics.Read moreRead less
Alarm Management - Silence is Golden. This project develops novel strategies and tools that aid alarm rationalisation in all types of process plants (e.g. gas, petrochemical, mining) by extracting groupings of related alarm tags from an enormous dataset of complex process data. These groupings are used in re-aligning the alarm systems, thus overcoming problems associated with the common practice of over-alarming, which may contribute to incidents like the Longford tragedy in Victoria. The approa ....Alarm Management - Silence is Golden. This project develops novel strategies and tools that aid alarm rationalisation in all types of process plants (e.g. gas, petrochemical, mining) by extracting groupings of related alarm tags from an enormous dataset of complex process data. These groupings are used in re-aligning the alarm systems, thus overcoming problems associated with the common practice of over-alarming, which may contribute to incidents like the Longford tragedy in Victoria. The approach is cost effective and improves alarm management. It addresses economic and safety concerns of the process industry as well as concerns raised in the study commissioned by the Institute of Engineers, Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100863
Funder
Australian Research Council
Funding Amount
$460,847.00
Summary
High-Efficiency, Modular and Low-Cost Hydrogen Liquefaction and Storage . Australia’s first modular hydrogen liquefaction and storage. This project aims to develop a novel multi-faceted cooling system and software to increase efficiency, lower cost, and improve the safety of hydrogen liquefaction and storage. The project will establish a new multi-disciplinary research capability in Australia and expand our fundamental knowledge to model, design, and build modular liquefaction and zero-boil-off ....High-Efficiency, Modular and Low-Cost Hydrogen Liquefaction and Storage . Australia’s first modular hydrogen liquefaction and storage. This project aims to develop a novel multi-faceted cooling system and software to increase efficiency, lower cost, and improve the safety of hydrogen liquefaction and storage. The project will establish a new multi-disciplinary research capability in Australia and expand our fundamental knowledge to model, design, and build modular liquefaction and zero-boil-off storage systems, allowing widespread distribution and usage of hydrogen. It will create a paradigm shift from traditional scale-up to modern number-up approaches. This level of innovation is crucial for Australia to lead the world in hydrogen and also enable accessible and sustainable clean energy sources for Australians.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0239647
Funder
Australian Research Council
Funding Amount
$290,000.00
Summary
Infrared chemical imaging and high temperature emission spectroscopy facility. Infrared spectroscopic imaging uses infrared radiation to analyse the chemical properties of microscopic samples in a fast and powerful manner. The images produced provide information about the different molecular chemistry at each pixel in the image. This is one of the latest and perhaps most important developments in vibrational spectroscopy, with wide applications in materials science, forensic science and the biol ....Infrared chemical imaging and high temperature emission spectroscopy facility. Infrared spectroscopic imaging uses infrared radiation to analyse the chemical properties of microscopic samples in a fast and powerful manner. The images produced provide information about the different molecular chemistry at each pixel in the image. This is one of the latest and perhaps most important developments in vibrational spectroscopy, with wide applications in materials science, forensic science and the biological sciences. It is an exceptional tool for the analysis of heterogeneous solids, whether these be seized drug samples, cancer cells, fibres left at a crime scene, layers of paint from a car or a Monet painting, or polymer blends.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100517
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Organocatalysis: A New Horizon for Synthesis of Organic Structures. The current technologies to synthesise organic substances, an important part of human life, often involve the use of excess amounts of reagents or precious and toxic metal catalysts, which incur high production costs and severe environmental impact. This project aims to use organocatalysis, chemical processes catalysed by stable, small, easily accessible, non-metallic organic compounds, to find a solution for these issues. Novel ....Organocatalysis: A New Horizon for Synthesis of Organic Structures. The current technologies to synthesise organic substances, an important part of human life, often involve the use of excess amounts of reagents or precious and toxic metal catalysts, which incur high production costs and severe environmental impact. This project aims to use organocatalysis, chemical processes catalysed by stable, small, easily accessible, non-metallic organic compounds, to find a solution for these issues. Novel organocatalytic methods will be designed and developed in order to promote environmentally friendly, highly efficient and selective chemical procedures for low cost production of laboratory organic substances and application in the industrial synthesis of potential agrochemicals and medicinal agents.Read moreRead less
Novel Statistical Methods For Genetic Epidemiology
Funder
National Health and Medical Research Council
Funding Amount
$481,505.00
Summary
We are in the midst of a genomics revolution that is transforming epidemiology, medicine and drug discovery. However, the scarcity of sophisticated statistical techniques to deal with the complicated problems inherent in genetic investigations of complex diseases is currently the critical factor limiting the success of human gene discovery programs. Statistical genetic methodology is currently one of the fastest developing areas of epidemiology. In information-intensive' areas such as genetic ep ....We are in the midst of a genomics revolution that is transforming epidemiology, medicine and drug discovery. However, the scarcity of sophisticated statistical techniques to deal with the complicated problems inherent in genetic investigations of complex diseases is currently the critical factor limiting the success of human gene discovery programs. Statistical genetic methodology is currently one of the fastest developing areas of epidemiology. In information-intensive' areas such as genetic epidemiology, genomics, and proteomics, there is a high demand for data analysis and statistical skills. WA has some world class expertise in statistical science, both in academia and in industry. However, this expertise has not yet been applied in a system way to genetic data analysis. We propose to undertake advanced methodological research in statistical genetics and bioinformatics, to produce easy-to-use and accessible software tools and resources that allow methodological advances to be accessed by the Australian research community, and to apply our new methods and tools both to specific disease research and to the developing human genome epidemiology (HuGE) enterprise in WA. These new initiatives in methodological research will draw together a number of currently separate research strands and will provide new tools and resources that will allow applied Australian programs to improve the efficiency of their research into the causes of important. Methodological development in both bioinformatics and statistical genetics are recognized international areas of need.Read moreRead less