Integrated governance of water and coal seam gas. This project aims to evaluate the governance of the water effects on unconventional gas, to develop legal and policy principles for the integration of these effects in an effective, efficient and legitimate manner, and to investigate problems posed for integrated and polycentric governance, more generally. Australia must meet its unconventional gas needs without harming its water resources. The project is expected to deliver effective and legitim ....Integrated governance of water and coal seam gas. This project aims to evaluate the governance of the water effects on unconventional gas, to develop legal and policy principles for the integration of these effects in an effective, efficient and legitimate manner, and to investigate problems posed for integrated and polycentric governance, more generally. Australia must meet its unconventional gas needs without harming its water resources. The project is expected to deliver effective and legitimate outcomes for water, energy and potentially other social and environmental issues, aiming to establish Australia as a leader in sustainable water management.Read moreRead less
Increasing organisational capacity of community residential units to facilitate ageing in place for people with intellectual disability. Unique challenges face the disability, aged care and health sectors because of the increased life expectancy of people with life-long intellectual disability (ID) and the likelihood of their premature ageing. Although this group is recognised by Federal and State governments as requiring specific and special service arrangements, little is known about adapting ....Increasing organisational capacity of community residential units to facilitate ageing in place for people with intellectual disability. Unique challenges face the disability, aged care and health sectors because of the increased life expectancy of people with life-long intellectual disability (ID) and the likelihood of their premature ageing. Although this group is recognised by Federal and State governments as requiring specific and special service arrangements, little is known about adapting disability and aged care services to their needs. This research will inform the development of policy and programs in the disability, aged care, and health sectors. The research aims to improve the capacity of disability group homes to respond to the health and ageing issues of older people with ID,to improve their quality of life.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100074
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
Facilities for automated high-throughput slide scanning and stereology. The equipment requested will facilitate the work of the Australian Mouse Brain Mapping Consortium, a consortium of Australian research groups collaborating to provide the only mouse model brain mapping capability in the country. The consortium brings together laboratory, neuroimaging and computational expertise in a comprehensive framework for imaging the mouse brain. This will help researchers to study mouse models of genet ....Facilities for automated high-throughput slide scanning and stereology. The equipment requested will facilitate the work of the Australian Mouse Brain Mapping Consortium, a consortium of Australian research groups collaborating to provide the only mouse model brain mapping capability in the country. The consortium brings together laboratory, neuroimaging and computational expertise in a comprehensive framework for imaging the mouse brain. This will help researchers to study mouse models of genetic and acquired disorders across the life-span. Remote viewing and analysis capabilities will help overcome the 'tyranny of distance', increasing national access to the facility. Repositories of digitised images will increase the availability of valuable research material to other Australian and international researchers.Read moreRead less
Mitochondrially targeted anti-cancer drugs modulate the mitochondrial genome. Successful cancer management requires novel therapeutical approaches. This project will test the effect of a new class of compounds that target mitochondria, the powerhouse of the cells, where they suppress expression of mitochondrial genes. By this mechanism, cancers that are resistant to apoptosis induction can be inhibited.
Keeping my place in the community: achieving successful ageing-in-place for people with intellectual and developmental disabilities. This project, in partnership with aged care and disability agencies across two states, aims to examine ways the aged care, social and health needs of people with intellectual and developmental disabilities may be met in rural and urban settings. It will explore mechanisms that will lead to a better integration of the aged care and disability sectors.
The effect of wastewater treatment on the ecotoxicity of chiral chemicals. This project aims to assess the environmental implications of pharmaceuticals discharged in effluents from wastewater treatment plants. Trace levels of human pharmaceuticals occur in sewage and urban waterways, but during sewage treatment, some pharmaceuticals can undergo a chemical transformation known as 'chiral inversion'. In some cases, this may convert relatively benign environmental contaminants to more ecologically ....The effect of wastewater treatment on the ecotoxicity of chiral chemicals. This project aims to assess the environmental implications of pharmaceuticals discharged in effluents from wastewater treatment plants. Trace levels of human pharmaceuticals occur in sewage and urban waterways, but during sewage treatment, some pharmaceuticals can undergo a chemical transformation known as 'chiral inversion'. In some cases, this may convert relatively benign environmental contaminants to more ecologically toxic species. This project will investigate why and how some pharmaceuticals become susceptible to chiral inversion and assess ecotoxicological differences. This work is expected to determine the significance of considering chiral inversion in environmental risk assessment, with applications to a broader range of chemicals including pesticides and industrial chemicals.Read moreRead less
Impact Of DTP Schedules On The Immunogenicity Of 2 Doses Of 13v-PCV Followed By An Early Booster
Funder
National Health and Medical Research Council
Funding Amount
$2,651,687.00
Summary
This project aims to come up with a vaccination schedule to make pneumococcal vaccines more effective and affordable for Fiji and other developing countries. We will evaluate schedules involving a 2 dose primary series in early infancy with a booster at 9 months of age. We will compare the immune responses to 3 different primary series and 2 booster options. The results of this project will be used to provide advice, at global and country levels, regarding introduction of pneumococcal vaccines.
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Adequate nutrition is necessary for recovery from illness. 30-40% of hospitalised patients may be malnourished. The critically ill are at higher risk because of increased energy requirements yet often receive less than 50% of required nutritional intake. Adequate nutrition therapy is associated with improved patient outcomes, such as reduced mortality and reduced infectious complications. Robust strategies to implement of evidence-based recommendations for nutrition therapy are required.
Smart management of disinfectant in chloraminated water-supply systems. Smart management of disinfectant in chloraminated water-supply systems. This project aims to develop an adaptive, real-time control system for managing disinfectant residuals in chloraminated water supply systems. While chloramine delivers microbiologically safe drinking water in warmer climates and in long distribution systems, it is largely unpredictable, costs water utilities millions of dollars annually, and has uncertai ....Smart management of disinfectant in chloraminated water-supply systems. Smart management of disinfectant in chloraminated water-supply systems. This project aims to develop an adaptive, real-time control system for managing disinfectant residuals in chloraminated water supply systems. While chloramine delivers microbiologically safe drinking water in warmer climates and in long distribution systems, it is largely unpredictable, costs water utilities millions of dollars annually, and has uncertain benefits. This project’s control system will be guided by quantitative models formulated from multi-pronged, fundamental experiments. The project will quantify microbial chloramine decay and determine mechanisms to increase predictability. The project will develop and demonstrate a real-time control technology which delivered microbiologically safe, cost-efficient drinking water to people in warmer climates, despite warming climate and increasing population.Read moreRead less