Wiring up the nervous system: how do axons detect molecular gradients? This project will improve our understanding of how the nervous system
becomes wired up during development. This will ultimately allow better
therapies for some types of developmental disorders, and for repairing
damaged connections for instance in the spinal cord. The theoretical
models developed will improve our understanding of the computations
necessary to generate appropriate wiring of the nervous system, which
may ....Wiring up the nervous system: how do axons detect molecular gradients? This project will improve our understanding of how the nervous system
becomes wired up during development. This will ultimately allow better
therapies for some types of developmental disorders, and for repairing
damaged connections for instance in the spinal cord. The theoretical
models developed will improve our understanding of the computations
necessary to generate appropriate wiring of the nervous system, which
may facilitate the development of self-organizing computing
devices. The project will also provide unique research training at the
interface of biology and computation, building capacity for such
interdisciplinary research throughout Australia.
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Discovery Early Career Researcher Award - Grant ID: DE130101191
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Formation of the osteocyte network in bone matrix. The formation of new bone, which occurs throughout life for bone renewal and acutely after fractures, entraps a network of cells that can detect micro-damage and direct repair mechanisms. Mathematical and computational methods will be used to understand how this network can lead to a self-detecting and self-repairing biomaterial.
Development and validation of virtual epithelial cancer models using an integrated modelling and experimental three-dimensional approach. The mathematical and experimental modelling of the human prostate and ovary applying quantitative bioengineering concepts will lead to virtual cancer models. This project aims to validate these multi-scale models to delineate biological and pathological avenues in healthy and disease tissue and improve prevention and treatment of prostate and ovarian cancer.