Preventing gendered violence: lessons from the global south. This project aims to study the establishment of police stations for women in Argentina as a key element to preventing gendered violence. This project aims to discover the extent to which the Argentinian interventions prevent the occurrence of gendered violence, and identify aspects that could inform the development of new approaches to preventing gendered violence in Australia. Anticipated outcomes include knowledge critical to develo ....Preventing gendered violence: lessons from the global south. This project aims to study the establishment of police stations for women in Argentina as a key element to preventing gendered violence. This project aims to discover the extent to which the Argentinian interventions prevent the occurrence of gendered violence, and identify aspects that could inform the development of new approaches to preventing gendered violence in Australia. Anticipated outcomes include knowledge critical to developing and implementing new ways to prevent gendered violence, with long-term benefits for national health, wellbeing and productivity.Read moreRead less
Farmers of the Future: the Challenges of Feminised Agriculture in India. Neoliberal economic policies are fundamentally transforming the social landscapes of rural India, causing a deep agrarian crisis. The agrarian changes accentuate the unequal consequences for poor women and men in relation to: production (labour, tenure); livelihood and food security; access to and ownership of assets such as land and water and access to agricultural innovations and institutions. This multiscalar project inv ....Farmers of the Future: the Challenges of Feminised Agriculture in India. Neoliberal economic policies are fundamentally transforming the social landscapes of rural India, causing a deep agrarian crisis. The agrarian changes accentuate the unequal consequences for poor women and men in relation to: production (labour, tenure); livelihood and food security; access to and ownership of assets such as land and water and access to agricultural innovations and institutions. This multiscalar project investigates the causes and consequences of feminisation of agriculture in India’s transitioning economy in order to understand how gender roles and relations are being re-shaped in communities and households in diverse socioeconomic and cultural contexts and agro-ecological areas.Read moreRead less
Microenvironments which support extramedullary hematopoiesis. Tissue regeneration is a breakthrough technology absolutely dependent on knowledge of the stem cells and stromal cells which support differentiation and tissue development. This project investigates the stromal cell types in spleen which can regenerate blood-forming cells in an ectopic tissue site or artificial matrix.
Veteran suicide: investigating the historical and social dimensions . This project aims to address veteran suicide by conducting an historical and cultural analysis of the ways government, the military and the community have understood, governed, and serviced veterans from 1914-present. This project will generate new knowledge, moving beyond orthodox medical and cultural assessments to explore wider historical, cultural and sociological relations of veteran suicide, including civil military rela ....Veteran suicide: investigating the historical and social dimensions . This project aims to address veteran suicide by conducting an historical and cultural analysis of the ways government, the military and the community have understood, governed, and serviced veterans from 1914-present. This project will generate new knowledge, moving beyond orthodox medical and cultural assessments to explore wider historical, cultural and sociological relations of veteran suicide, including civil military relations, and the influence of the veteran sector and families and community. The project will develop an innovative survey that will form the foundation of a longitudinal social health and wellbeing dataset on veterans, and contribute to policy and service provision to reduce veteran suicide and improve their wellbeing.Read moreRead less
Gain from pain: new tools from venomous animals for exploring pain pathways. This project aims to explore animal venoms for new pain-causing toxins, to determine their structure and mechanism of action. Many venomous animals use their venom defensively and envenomation is frequently associated with rapid and often excruciating pain. In most cases the molecular mechanisms by which they achieve this is unknown. Using biochemical, pharmacological and biophysical techniques, this project expects to ....Gain from pain: new tools from venomous animals for exploring pain pathways. This project aims to explore animal venoms for new pain-causing toxins, to determine their structure and mechanism of action. Many venomous animals use their venom defensively and envenomation is frequently associated with rapid and often excruciating pain. In most cases the molecular mechanisms by which they achieve this is unknown. Using biochemical, pharmacological and biophysical techniques, this project expects to uncover toxins that employ new mechanisms of pain signalling, leading to new insights into pain physiology.Read moreRead less
Molecular mechanisms of signalling by plant immune receptors. This project aims to understand how resistance proteins function and to find new sources of these proteins. Plant diseases account for 15% loss of global crop production, representing a threat to food security. Fungicides, one key form of protection, represent environmental concerns. The other key form of protection corresponds to resistance gene breeding, which is limited by lengthy breeding processes, restricted choice of genes from ....Molecular mechanisms of signalling by plant immune receptors. This project aims to understand how resistance proteins function and to find new sources of these proteins. Plant diseases account for 15% loss of global crop production, representing a threat to food security. Fungicides, one key form of protection, represent environmental concerns. The other key form of protection corresponds to resistance gene breeding, which is limited by lengthy breeding processes, restricted choice of genes from sexually compatible species and short effective time spans in the field. Building on previous research, this project aims to characterise the molecular basis of the Toll/interleukin-1 receptor domain-mediated nicotinamide adenine dinucleotide (NAD+) cleavage and the structural architecture of plant NLR complexes. This knowledge will support the long-term objective of protecting crops from pathogens.Read moreRead less
Understanding the molecular function of plant disease resistance proteins, pathogen effectors and their interaction to protect Australian agriculture. This project aims to understand the processes that enable resistant plants to detect and respond to pathogen attack. The acquired knowledge will form the foundation for durable plant disease resistance measures that can be applied to a wide range of crop diseases in an environmentally sustainable manner.
Structural basis of plant immune receptor signaling. Plants detect invading pathogens and trigger immune responses in a process called “effector-triggered immunity”, in which pathogen effector (avirulence) proteins are recognized by plant resistance proteins, typically so-called “plant NLRs”. Ongoing work in the applicants’ laboratories has shown that oligomerization into “resistosomes” and NAD+ (nicotinamide adenine dinucleotide) cleavage play central roles in the process. Building on these dat ....Structural basis of plant immune receptor signaling. Plants detect invading pathogens and trigger immune responses in a process called “effector-triggered immunity”, in which pathogen effector (avirulence) proteins are recognized by plant resistance proteins, typically so-called “plant NLRs”. Ongoing work in the applicants’ laboratories has shown that oligomerization into “resistosomes” and NAD+ (nicotinamide adenine dinucleotide) cleavage play central roles in the process. Building on these data, the project aims to characterize the structures of the signaling molecules resulting from TIR (Toll/interleukin-1 receptor) domain-mediated NAD+ cleavage and the structural architecture of plant NLR resistosomes. This knowledge will support the long-term objective of protecting crops from pathogens.Read moreRead less
Directed evolution of enzymes for bioremediation: structure function studies of bimetalloenzymes. We will evolve enzymes that degrade organophosphate pesticides (OPs) that are used in Australian agriculture. Although these OPs were designed to kill insects they are closely related to chemical warfare agents and are known to be toxic to humans. Bacteria have acquired a number of enzymes that degrade some OPs. One such enzyme has been used in field trials demonstrating its potential to degrade OP ....Directed evolution of enzymes for bioremediation: structure function studies of bimetalloenzymes. We will evolve enzymes that degrade organophosphate pesticides (OPs) that are used in Australian agriculture. Although these OPs were designed to kill insects they are closely related to chemical warfare agents and are known to be toxic to humans. Bacteria have acquired a number of enzymes that degrade some OPs. One such enzyme has been used in field trials demonstrating its potential to degrade OP residues. However, many pesticides are not removed rapidly and OP-degrading enzymes require modification(s) if they are to be useful environmental reagents - this can be achieved with directed evolution. Read moreRead less
Methods for Protein Structure Analysis by Electron Paramagnetic Resonance. This highly interdisciplinary project aims to establish new tools to analyse the structure and motions of proteins that are otherwise difficult to study. A combination of advanced biochemistry, modern magnetic spectroscopy methods, and high-performance computing techniques will be applied to study proteins at physiological concentrations and in complex environments. New techniques will be developed and tested on proteins ....Methods for Protein Structure Analysis by Electron Paramagnetic Resonance. This highly interdisciplinary project aims to establish new tools to analyse the structure and motions of proteins that are otherwise difficult to study. A combination of advanced biochemistry, modern magnetic spectroscopy methods, and high-performance computing techniques will be applied to study proteins at physiological concentrations and in complex environments. New techniques will be developed and tested on proteins of high biochemical or biomedical importance, and the approach will be applied to established drug targets.Read moreRead less