Development of a novel high yield cell-free protein expression system. Recombinant proteins are used as vaccines, drugs, and research tools, as well as food and detergent additives, comprising a A$100 billion international market. Their production requires laborious, expensive, and time-consuming construction of transgenic organisms or cells. Alternatively, recombinant proteins can be produced in extracts prepared from cells or organisms. The aim of this proposal is to develop a new technology t ....Development of a novel high yield cell-free protein expression system. Recombinant proteins are used as vaccines, drugs, and research tools, as well as food and detergent additives, comprising a A$100 billion international market. Their production requires laborious, expensive, and time-consuming construction of transgenic organisms or cells. Alternatively, recombinant proteins can be produced in extracts prepared from cells or organisms. The aim of this proposal is to develop a new technology that will make cell-free production of recombinant proteins rapid, cheap, and scalable. This will advance Australia’s intellectual leadership in the area of biotechnology and will bring numerous economic benefits by accelerating pharmaceutical development. Read moreRead less
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
Venomics: Molecular and functional analysis of Australian snake venoms for development of human therapeutics. Australian snake venoms are lethal cocktails with potent effects on mammalian physiological processes, designed to immobilize and kill prey animals. Major targets of venom components are the nervous and blood coagulation systems but there is reason to believe that venoms have many other as yet unrecognized effects on mammalian systems. The project will combine techniques of modern mole ....Venomics: Molecular and functional analysis of Australian snake venoms for development of human therapeutics. Australian snake venoms are lethal cocktails with potent effects on mammalian physiological processes, designed to immobilize and kill prey animals. Major targets of venom components are the nervous and blood coagulation systems but there is reason to believe that venoms have many other as yet unrecognized effects on mammalian systems. The project will combine techniques of modern molecular biology (particularly transcriptomics and proteomics) with functional and structural analysis of purified venom components. Venoms from approximately 20 Australian snakes will be studied to reveal lead compounds for improved human pharmaceuticals against common disorders such as high blood pressure, bleeding and stroke.Read moreRead less
Smart Nanocapsules for Efficient Cellular Delivery of Bioactive Peptide Drugs. This project will bring about practical benefits in terms of developing efficient therapeutic drug delivery systems, which has a market growth estimated to be ca. 23% p.a. in the world. The novel encapsulation technology developed in this project is not only desirable for biomolecules but also applicable for other functional materials and will find wide applications in a number of fields, such as chemical, food proces ....Smart Nanocapsules for Efficient Cellular Delivery of Bioactive Peptide Drugs. This project will bring about practical benefits in terms of developing efficient therapeutic drug delivery systems, which has a market growth estimated to be ca. 23% p.a. in the world. The novel encapsulation technology developed in this project is not only desirable for biomolecules but also applicable for other functional materials and will find wide applications in a number of fields, such as chemical, food processing and cosmetic industries. Successful completion of the project can also strengthen our capacity to participate in new areas of research and positioning Australia at the forefront of bionanotechnology.Read moreRead less
Engaging Men and Boys in Violence Prevention: Effective directions for practice. Violence against women is a significant issue of policy effort and community concern. In the past decade, there has been an increasing emphasis on the need to engage men and boys in preventing and reducing men’s violence against women, both nationally and internationally. However, little is known about what works and does not work. Using robust evaluations of key strategies and interventions, this project aims to pr ....Engaging Men and Boys in Violence Prevention: Effective directions for practice. Violence against women is a significant issue of policy effort and community concern. In the past decade, there has been an increasing emphasis on the need to engage men and boys in preventing and reducing men’s violence against women, both nationally and internationally. However, little is known about what works and does not work. Using robust evaluations of key strategies and interventions, this project aims to produce a systematic framework for effective practice in engaging men and boys in preventing violence against women. It aims to produce both significant scholarly insights regarding gender and violence prevention and practical directions for policy and programming.Read moreRead less
Power in the Union? An Examination of Women-only Unions in Japan and South Korea. This project will analyse the development of women-only unions in Japan and South Korea. Women-only unions have existed and still exist in a number of countries but despite the growing numbers of women in unions, the creation of women-only unions has not been a popular organising strategy for pursuing issues of importance to women workers. This project is innovative as it explores the contemporary (re)emergence of ....Power in the Union? An Examination of Women-only Unions in Japan and South Korea. This project will analyse the development of women-only unions in Japan and South Korea. Women-only unions have existed and still exist in a number of countries but despite the growing numbers of women in unions, the creation of women-only unions has not been a popular organising strategy for pursuing issues of importance to women workers. This project is innovative as it explores the contemporary (re)emergence of women-only unions in Japan and South Korea. Through interviews, this project will explore the Western theoretical concepts of 'same/difference' and examine their applicability to an analysis of women-only unions in Japan and South Korea.Read moreRead less
LGBTI experiences of cancer survivorship and care. This project aims to understand the experiences and concerns of cancer survivors and carers within lesbian, gay, bisexual, transgender and intersex communities. This vulnerable population reports higher rates of cancer related distress and dissatisfaction with care than the general population. This project will examine the perspectives of cancer survivors, their carers, and professional stakeholders, to inform targeted patient and carer resource ....LGBTI experiences of cancer survivorship and care. This project aims to understand the experiences and concerns of cancer survivors and carers within lesbian, gay, bisexual, transgender and intersex communities. This vulnerable population reports higher rates of cancer related distress and dissatisfaction with care than the general population. This project will examine the perspectives of cancer survivors, their carers, and professional stakeholders, to inform targeted patient and carer resources, and recommendations for cancer care and policy.Read moreRead less
Developing a novel method for delivering a behavioral intervention for decreasing morbidity in women with a chronic disease: a randomized controlled trial. Currently there are 209.8 deaths from heart, stroke and vascular diseases per 100 000 of the Australian female population each year, with the rates being considerably high in the elderly female population. Despite the potential benefits of behavioural strategies to prevent morbidity in women with chronic disease, studies to date have not targ ....Developing a novel method for delivering a behavioral intervention for decreasing morbidity in women with a chronic disease: a randomized controlled trial. Currently there are 209.8 deaths from heart, stroke and vascular diseases per 100 000 of the Australian female population each year, with the rates being considerably high in the elderly female population. Despite the potential benefits of behavioural strategies to prevent morbidity in women with chronic disease, studies to date have not targeted women who already have a chronic disease in a clinical setting. This research study will address this, helping postmenopausal women who have chronic disease change negative health behaviours and increase physical activity and self efficacy, improve quality of life and decrease blood pressure, obesity and tobacco use.Read moreRead less
Descartes' Ontology of Everyday Life. Australia has a strong international reputation in philosophy and the history of philosophy. This project will contribute to our standing in the international community of scholars and to the teaching of Australian students in the historical origins of contemporary ideas and problems. It will furthermore contribute to the growing recognition of early modern interdisciplinary studies within Australia by drawing on ideas from the history of science, early mode ....Descartes' Ontology of Everyday Life. Australia has a strong international reputation in philosophy and the history of philosophy. This project will contribute to our standing in the international community of scholars and to the teaching of Australian students in the historical origins of contemporary ideas and problems. It will furthermore contribute to the growing recognition of early modern interdisciplinary studies within Australia by drawing on ideas from the history of science, early modern philosophy, medieval philosophy and the history of early modern thought and ideas.Read moreRead less
Sexual well-being and ageing: a study of older Australian women. This research addresses important issues of ageism and sexism that together affect older women's health and well-being. The findings will inform the link between aging, sexuality and more general dimensions of health and well-being and advance our understanding of issues central to policy and services for older Australians.