Parasite virulence: the role of activation and suppression of P2X7 receptors. Toxoplasmosis and leishmaniasis pose a threat to the health and well-being of the Australian human and animal populations. Around 6-8 million Australians are infected with Toxoplasma, a parasite that can cause severe problems in immunosuppressed individuals and birth defects and miscarriage in pregnant women with a primary infection. Toxoplasmosis is also the main cause of abortion and stillbirth in Australian sheep. L ....Parasite virulence: the role of activation and suppression of P2X7 receptors. Toxoplasmosis and leishmaniasis pose a threat to the health and well-being of the Australian human and animal populations. Around 6-8 million Australians are infected with Toxoplasma, a parasite that can cause severe problems in immunosuppressed individuals and birth defects and miscarriage in pregnant women with a primary infection. Toxoplasmosis is also the main cause of abortion and stillbirth in Australian sheep. Leishmaniasis, recently found in Australia, is a risk for overseas travellers, livestock and wildlife. This research will provide an understanding of what makes these parasites successful, paving the way for development of novel drugs to combat these chronic diseases.Read moreRead less
Special Research Initiatives - Grant ID: SR0354622
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network ....Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the early embryo have major consequences for the development of individuals. The aim of this Network is to harness the resources of leading researchers from the previously distinct disciplines of developmental biology and developmental physiology to better understand developmental regulatory networks and how environmental factors impinge on them. The formation of such a Network is unique, timely and strategic in that it will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
Trends in Time: Work, Family and Social Policy in Australia 1992-2006. This project will contribute to the national priority goal of 'strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, and fulfilling lives', within the National Research Priority of 'promoting good health and well being for all Australians'. It will provide sound new evidence for effective strategies fostering the policy goals of reducing stress on families, maintaining ....Trends in Time: Work, Family and Social Policy in Australia 1992-2006. This project will contribute to the national priority goal of 'strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, and fulfilling lives', within the National Research Priority of 'promoting good health and well being for all Australians'. It will provide sound new evidence for effective strategies fostering the policy goals of reducing stress on families, maintaining fertility and encouraging women into paid work. Identifying measures that most support men and women to balance work-family commitments, to spend adequate time with their children and social networks, and most facilitate female workforce participation, will promote national wellbeing. Read moreRead less
Discipline, Morale and Winning Wars: Understanding the Relationships Between Discipline and Combat Performance in Low-Intensity Conflict. Discipline and morale are key elements in combat performance, particularly in Low-Intensity Conflict (LIC). This project examines the relationships between discipline, morale and combat performance using the Australian Army in Vietnam as a case study. It provides insights into better understanding and managing discipline and morale to produce and sustain comba ....Discipline, Morale and Winning Wars: Understanding the Relationships Between Discipline and Combat Performance in Low-Intensity Conflict. Discipline and morale are key elements in combat performance, particularly in Low-Intensity Conflict (LIC). This project examines the relationships between discipline, morale and combat performance using the Australian Army in Vietnam as a case study. It provides insights into better understanding and managing discipline and morale to produce and sustain combat performance. It assists the Army to avoid the negative effects of failures in discipline and morale that produced the My Lai massacre and the Abu Ghraib fiasco. It also helps position Australia internationally as a contributor to the better understanding of LIC, and fills a gap in Australian historiography of war.Read moreRead less
Understanding Low-Intensity Conflict. Since 1945, Low-Intensity Conflict (LIC) has become the dominant form of warfare. Conventional armies have a poor record of success in fighting LIC. This project uses the records of the Australian Army's operations in the Vietnam War to better understand it's operational performance there and to unearth insights into the conduct of LIC. The project has the potential to reduce casualties, both military and civilian, and assist the Army in selecting new war-fi ....Understanding Low-Intensity Conflict. Since 1945, Low-Intensity Conflict (LIC) has become the dominant form of warfare. Conventional armies have a poor record of success in fighting LIC. This project uses the records of the Australian Army's operations in the Vietnam War to better understand it's operational performance there and to unearth insights into the conduct of LIC. The project has the potential to reduce casualties, both military and civilian, and assist the Army in selecting new war-fighting technologies, designing training and developing doctrine for future LIC. The project will raise Australia's profile in theorising about this troubling but increasingly common form of warfare.Read moreRead less
Reducing health disparities for older LGBTI Australians. Reducing health disparities for older LGBTI Australians. This project aims to optimise health and aged care services throughout Australia, by bringing together researchers and key organisations in the health, aged, and lesbian, gay, bisexual, transgender and intersex (LGBTI) sectors to build a much-needed evidence base. Older LGBTI Australians have vastly poorer health outcomes than the broader population. This project will provide detaile ....Reducing health disparities for older LGBTI Australians. Reducing health disparities for older LGBTI Australians. This project aims to optimise health and aged care services throughout Australia, by bringing together researchers and key organisations in the health, aged, and lesbian, gay, bisexual, transgender and intersex (LGBTI) sectors to build a much-needed evidence base. Older LGBTI Australians have vastly poorer health outcomes than the broader population. This project will provide detailed quantitative and qualitative data on the challenges and needs of older LGBTI Australians and service providers, and develop essential resources so policymakers and service providers can reduce older LGBTI Australians’ health disparities.Read moreRead less
Completing the Gallipoli story: Researching Turkish Archives for a More Comprehensive History. Both Australia and Turkey see the Gallipoli Campaign as a defining event. Australian perceptions of the Campaign are based on C.E.W. Bean's Official History and a number of popular publications. Yet, despite the vast collection of material held in Turkish archives, existing accounts give scant attention to Turkish operations leaving the story incomplete. This project will rectify that imbalance by loca ....Completing the Gallipoli story: Researching Turkish Archives for a More Comprehensive History. Both Australia and Turkey see the Gallipoli Campaign as a defining event. Australian perceptions of the Campaign are based on C.E.W. Bean's Official History and a number of popular publications. Yet, despite the vast collection of material held in Turkish archives, existing accounts give scant attention to Turkish operations leaving the story incomplete. This project will rectify that imbalance by locating and translating key documents-battlefield reports and signals, War Ministry communications, records of prisoner interrogations, aircraft logs and diaries. The result will be a comprehensive history that will contribute to the deepening relationship between Australia and Turkey as we approach the centenary of the Campaign. Read moreRead less
Improving the Well-Being of Low Socioeconomic Status Students at University. This project aims to investigate a new approach to improving the mental well-being of university students from low socioeconomic status (SES) backgrounds. University students have a high risk of experiencing mental health problems, and students from low SES backgrounds have a particularly high risk. This project aims to investigate university-relevant Facebook groups as a method of improving the mental well-being of low ....Improving the Well-Being of Low Socioeconomic Status Students at University. This project aims to investigate a new approach to improving the mental well-being of university students from low socioeconomic status (SES) backgrounds. University students have a high risk of experiencing mental health problems, and students from low SES backgrounds have a particularly high risk. This project aims to investigate university-relevant Facebook groups as a method of improving the mental well-being of low SES students by improving their online social integration at university. Expected outcomes and benefits include a scalable, low-cost approach to reducing an SES inequality that costs Australia billions of dollars each year.Read moreRead less
Investigating The Cellular Response To Iron-Depletion: The Trilogy Of ASK1, Thioredoxin And Ribonucleotide Reductase
Funder
National Health and Medical Research Council
Funding Amount
$552,572.00
Summary
Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for t ....Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.Read moreRead less