Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100015
Funder
Australian Research Council
Funding Amount
$523,899.00
Summary
Integrated Tip-Enabled Nanofabrication and Characterisation at Atomic Scale. This project aims to establish the most advanced all-in-one multifunctional system going beyond the best system in the world. This facility is expected to combine tip-enabled nanofabrication, imaging, photo-/electrochemical, and electromechanical measurement to realise atomically precisely controlled nanofabrication, in-situ imaging, and real-time measurement of single active sites in micro and nanoscale devices.The pro ....Integrated Tip-Enabled Nanofabrication and Characterisation at Atomic Scale. This project aims to establish the most advanced all-in-one multifunctional system going beyond the best system in the world. This facility is expected to combine tip-enabled nanofabrication, imaging, photo-/electrochemical, and electromechanical measurement to realise atomically precisely controlled nanofabrication, in-situ imaging, and real-time measurement of single active sites in micro and nanoscale devices.The proposed facility features high-quality measurements in an unmatched spatial and temporal range, allowing studying physical and chemical phenomena that are difficult to detect using conventional methods. The proposed integrated system will be the first of its kind in Australia. Read moreRead less
Unravelling the enigma of turbulence by integrating simulation & modelling. This project will transform how turbulence and flow-induced noise is understood and predicted to help meet the challenge of ever-growing transport and energy demands in an affordable and sustainable way. This will be achieved by integrating the latest simulation advances with unique machine-learning approaches. The expected outcome will be a paradigm shift in how turbulence and noise models are created and used, informed ....Unravelling the enigma of turbulence by integrating simulation & modelling. This project will transform how turbulence and flow-induced noise is understood and predicted to help meet the challenge of ever-growing transport and energy demands in an affordable and sustainable way. This will be achieved by integrating the latest simulation advances with unique machine-learning approaches. The expected outcome will be a paradigm shift in how turbulence and noise models are created and used, informed by new scientific knowledge and data. The proliferation of these new models will allow the design and operation of more efficient, reliable and quieter technologies in the aerospace, naval and energy industries, benefitting the Australian economy and environment, and raise the international profile of our scientists.Read moreRead less
Photoelectrode design for solar driven methane to methanol conversion. This project aims to achieve efficient photoelectrocatalytic partial oxidation of greenhouse gas methane for methanol production with high selectivity. The program will design new semiconductor materials through rational defect engineering and co-catalyst selection to revolutionise methane conversion. The expected outcomes include sustainable processes to convert methane into valuable liquid chemicals like methanol, and compr ....Photoelectrode design for solar driven methane to methanol conversion. This project aims to achieve efficient photoelectrocatalytic partial oxidation of greenhouse gas methane for methanol production with high selectivity. The program will design new semiconductor materials through rational defect engineering and co-catalyst selection to revolutionise methane conversion. The expected outcomes include sustainable processes to convert methane into valuable liquid chemicals like methanol, and comprehensive understanding on functional material design for solar driven catalytic reactions. The significant benefits will include revolutionary methane mitigation technologies and sustainable processes for value-added chemical production, alleviating key environmental and energy challenges facing Australia and the world.Read moreRead less
Solar driven methane conversion for green methanol production. This project aims to develop advanced photoelectrode materials for solar driven methane partial oxidation to produce methanol. The key concepts are to develop new semiconductor devices and alloy metal cocatalysts in solving the slow charge and mass transfer challenges in catalytic methane partial oxidation reactions. The expected outcomes include ground-breaking approaches for catalytic materials design, efficient solar fuel producti ....Solar driven methane conversion for green methanol production. This project aims to develop advanced photoelectrode materials for solar driven methane partial oxidation to produce methanol. The key concepts are to develop new semiconductor devices and alloy metal cocatalysts in solving the slow charge and mass transfer challenges in catalytic methane partial oxidation reactions. The expected outcomes include ground-breaking approaches for catalytic materials design, efficient solar fuel production and cutting-edge knowledge on methane activation mechanism. The program is aligned with Australia’s Net-Zero Emission 2050 target, representing an innovative pathway in converting greenhouse gases into valuable chemicals, which will bring environmental and economic benefits to Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100357
Funder
Australian Research Council
Funding Amount
$409,118.00
Summary
Catalyst design for converting carbon dioxide into valuable chemicals. This project aims to use solar energy to convert carbon dioxide, the primary greenhouse gas that drives global climate change, into valuable chemicals via catalytic reduction. This project expects to facilitate the selective production of valuable ethylene from carbon dioxide reduction by developing novel cocatalyst materials derived from metal-oxo cluster molecules. Expected outcomes include fundamental understanding of the ....Catalyst design for converting carbon dioxide into valuable chemicals. This project aims to use solar energy to convert carbon dioxide, the primary greenhouse gas that drives global climate change, into valuable chemicals via catalytic reduction. This project expects to facilitate the selective production of valuable ethylene from carbon dioxide reduction by developing novel cocatalyst materials derived from metal-oxo cluster molecules. Expected outcomes include fundamental understanding of the structure-property relationship in new catalytic systems, and technological breakthroughs in reducing carbon dioxide emissions. The success of this project will bring significant environmental and economic benefits, and position Australia at the frontier of global transition to a low-carbon economy.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100429
Funder
Australian Research Council
Funding Amount
$406,177.00
Summary
Bioinspired Photocatalysts for Solar-Driven Hydrogen Peroxide Production. This project aims to develop advanced photocatalysts that can efficiently produce hydrogen peroxide from just water, air, and sunlight. By mimicking the structure and function of the natural photosynthetic apparatus, the key innovations are expected in the design of reaction-oriented conjugated polymer-based photocatalysts at the atomic and molecular nanostructure levels. It expects to generate new knowledge in artificial ....Bioinspired Photocatalysts for Solar-Driven Hydrogen Peroxide Production. This project aims to develop advanced photocatalysts that can efficiently produce hydrogen peroxide from just water, air, and sunlight. By mimicking the structure and function of the natural photosynthetic apparatus, the key innovations are expected in the design of reaction-oriented conjugated polymer-based photocatalysts at the atomic and molecular nanostructure levels. It expects to generate new knowledge in artificial photosynthesis and rational design of functional materials, and sustainable technology for hydrogen peroxide production. This cross-disciplinary research will benefit Australia by the development of biomimetic catalysts for advancing solar energy conversion and enabling sustainable manufacturing of commodity chemicals. Read moreRead less
Role of Tau and Synapsin in clustering distinct synaptic vesicle pools. Neurotransmitter-containing synaptic vesicles (SVs) are highly enriched in specific locations of brain cells, called nerve terminals via an unknown mechanism. The clustering of SVs depend on the phosphorylation of an unknown set of proteins. Two key proteins have been identified for their phosphorylation pattern and their potential to form membraneless compartments: tau and synapsin. Using highly innovative single-molecule s ....Role of Tau and Synapsin in clustering distinct synaptic vesicle pools. Neurotransmitter-containing synaptic vesicles (SVs) are highly enriched in specific locations of brain cells, called nerve terminals via an unknown mechanism. The clustering of SVs depend on the phosphorylation of an unknown set of proteins. Two key proteins have been identified for their phosphorylation pattern and their potential to form membraneless compartments: tau and synapsin. Using highly innovative single-molecule super-resolution microscopy, this grant will uncover how tau and synapsin phosphorylation controls the clustering of SVs thereby regulating neurotransmitter release. This project uses improved nanoscopic technologies and international
collaborations to unveil novel avenues in our understanding of brain communication.Read moreRead less
Super-resolving neurotransmitter release machinery during priming. Understanding how neurons communicate in the brain is one of the most challenging feats in neuroscience. The assembly of the molecular machinery involved in communication is unknown. This grant aims to understand how priming molecules Munc18 and Munc13, undergo a series of molecular steps leading to the release of neurotransmitter. Using innovative single-molecule super-resolution imaging we will uncover how Munc18 and Munc13 are ....Super-resolving neurotransmitter release machinery during priming. Understanding how neurons communicate in the brain is one of the most challenging feats in neuroscience. The assembly of the molecular machinery involved in communication is unknown. This grant aims to understand how priming molecules Munc18 and Munc13, undergo a series of molecular steps leading to the release of neurotransmitter. Using innovative single-molecule super-resolution imaging we will uncover how Munc18 and Munc13 are spatially and temporally organised to mediate communication. By elucidating how nanoclustering of these essential proteins enables key steps, this grant will reveal how brain cells communicate. This may then provide new opportunities to optimise underlying functions such as cognition, sensory and motor processing.Read moreRead less
Click chemistry to reveal how neurons and glia shape perineuronal nets . The extracellular matrix (ECM) and its perineuronal nets (which are net-like structures with holes wrapped around neurons) are largely underexplored, despite representing a remarkable 20% of the brain’s total volume and having been suggested to be involved in many brain functions. Interestingly, digestion of the ECM improves learning and memory, but deficits return once the ECM has reformed. However, how this ECM remodellin ....Click chemistry to reveal how neurons and glia shape perineuronal nets . The extracellular matrix (ECM) and its perineuronal nets (which are net-like structures with holes wrapped around neurons) are largely underexplored, despite representing a remarkable 20% of the brain’s total volume and having been suggested to be involved in many brain functions. Interestingly, digestion of the ECM improves learning and memory, but deficits return once the ECM has reformed. However, how this ECM remodelling is organised at a cell-type level is not understood. Here we aim to close this knowledge gap, using cutting-edge technology including bioconjugation and ultrasound-mediated cargo delivery. Together, this project aims to contribute to a deeper understanding of this major brain compartment in neuronal function. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100561
Funder
Australian Research Council
Funding Amount
$462,237.00
Summary
Understanding how platelets mediate new neuron formation in the adult brain. Exercise boosts the generation of new nerve cells from adult neural stem cells in the part of the brain responsible for learning and memory, the hippocampus. This project aims to investigate the mechanisms behind this effect, in particular, how blood cells known as platelets mediate this process. The expected outcomes include the discovery of new communication pathways between platelets and the brain following exercise ....Understanding how platelets mediate new neuron formation in the adult brain. Exercise boosts the generation of new nerve cells from adult neural stem cells in the part of the brain responsible for learning and memory, the hippocampus. This project aims to investigate the mechanisms behind this effect, in particular, how blood cells known as platelets mediate this process. The expected outcomes include the discovery of new communication pathways between platelets and the brain following exercise and will determine the importance of these blood cells in mediating brain function. This will help to explain how exercise affects the brain and may benefit Australian society through the implementation of new methods to support learning and memory in schools and workplaces, thereby enhancing performance and productivity.Read moreRead less