Photoelectrode design for solar driven methane to methanol conversion. This project aims to achieve efficient photoelectrocatalytic partial oxidation of greenhouse gas methane for methanol production with high selectivity. The program will design new semiconductor materials through rational defect engineering and co-catalyst selection to revolutionise methane conversion. The expected outcomes include sustainable processes to convert methane into valuable liquid chemicals like methanol, and compr ....Photoelectrode design for solar driven methane to methanol conversion. This project aims to achieve efficient photoelectrocatalytic partial oxidation of greenhouse gas methane for methanol production with high selectivity. The program will design new semiconductor materials through rational defect engineering and co-catalyst selection to revolutionise methane conversion. The expected outcomes include sustainable processes to convert methane into valuable liquid chemicals like methanol, and comprehensive understanding on functional material design for solar driven catalytic reactions. The significant benefits will include revolutionary methane mitigation technologies and sustainable processes for value-added chemical production, alleviating key environmental and energy challenges facing Australia and the world.Read moreRead less
High temperature corrosion induced by multiple secondary oxidants . Heat resisting chromia-forming alloys passivate successfully in clean, dry air at temperatures up to about 950°C. However, this performance is degraded by secondary oxidants (carbon, sulphur, chlorine, water vapour), leading to corrosion failure in important industries. The project aims to investigate the effect of these secondary oxidants on corrosion behaviour of chromia-forming alloys, to identify interactions between multipl ....High temperature corrosion induced by multiple secondary oxidants . Heat resisting chromia-forming alloys passivate successfully in clean, dry air at temperatures up to about 950°C. However, this performance is degraded by secondary oxidants (carbon, sulphur, chlorine, water vapour), leading to corrosion failure in important industries. The project aims to investigate the effect of these secondary oxidants on corrosion behaviour of chromia-forming alloys, to identify interactions between multiple oxidants within the scale, to establish the mechanisms of oxide scale penetration by foreign species, and to evaluate scales on different alloy types. The results will provide a basis for improved design/selection of heat resisting chromia-forming alloys, key to power generation industries.Read moreRead less
Energy-efficient liquid-flow system for electroreduction of carbon dioxide. Concerns about fossil fuel depletion and rising carbon emissions have brought about an urgent demand for carbon dioxide (CO2) capture and utilisation technologies. Facilitated by the mechanism-driven catalyst development and engineering innovation, this project aims to deliver a durable and cost-effective approach to electrochemical transformation of CO2 into the valuable products. The proposed automatic liquid-flow reac ....Energy-efficient liquid-flow system for electroreduction of carbon dioxide. Concerns about fossil fuel depletion and rising carbon emissions have brought about an urgent demand for carbon dioxide (CO2) capture and utilisation technologies. Facilitated by the mechanism-driven catalyst development and engineering innovation, this project aims to deliver a durable and cost-effective approach to electrochemical transformation of CO2 into the valuable products. The proposed automatic liquid-flow reactor system is expected to enable an energy efficient and practical viable CO2 reduction in benign aqueous electrolytes. The resulting innovations will not only reduce the environmental impact of atmospheric CO2 but also generate highly concentrated industrial feedstocks for the sustainable production of commodity chemicals.Read moreRead less
Low cost aqueous rechargeable zinc batteries for grid-scale energy storage. This project aims to advance energy storage technology by developing high energy aqueous rechargeable zinc batteries, which are the most promising choice for large-scale electrical energy storage, in particular for smart electric grids, owing to their low cost, high safety, and eco-friendly features. The success of this project will advance our fundamental understanding of aqueous rechargeable batteries, provide techniqu ....Low cost aqueous rechargeable zinc batteries for grid-scale energy storage. This project aims to advance energy storage technology by developing high energy aqueous rechargeable zinc batteries, which are the most promising choice for large-scale electrical energy storage, in particular for smart electric grids, owing to their low cost, high safety, and eco-friendly features. The success of this project will advance our fundamental understanding of aqueous rechargeable batteries, provide techniques for the development of a low-cost, high energy, and long life system for renewable energy storage, and benefit Australia's environment, economy, and sustainability.Read moreRead less
Lithium-rich cathode materials for high-energy lithium-ion batteries. This project aims to develop lithium-rich cathode materials for a new generation of high-energy lithium-ion batteries. These innovative materials could double the capacity of commercial cathodes, thereby doubling the energy density of lithium-ion batteries. A further increase is anticipated from fundamental insights into anionic redox. Expected outcomes include materials with optimised architecture and chemistry, stabilisation ....Lithium-rich cathode materials for high-energy lithium-ion batteries. This project aims to develop lithium-rich cathode materials for a new generation of high-energy lithium-ion batteries. These innovative materials could double the capacity of commercial cathodes, thereby doubling the energy density of lithium-ion batteries. A further increase is anticipated from fundamental insights into anionic redox. Expected outcomes include materials with optimised architecture and chemistry, stabilisation of lithium-rich cathodes, identification of redox mechanism of lithium-rich cathode materials, technologies for producing lithium-rich cathode materials on a large scale and fabrication of new generation high-energy lithium-ion batteries. This project will have benefits especially in the transport and energy sectors. Read moreRead less
Augmenting the activity of glyoxalase-1 to increase dicarbonyl clearance . Reactive intermediates generated during our metabolism contribute to ageing. Glyoxalase-1 is a key defence enzyme against these toxic intermediates and therefore ageing itself. This project aims to investigate novel pathways how the expression and activity of glyoxalase-1 are regulated. This interdisciplinary project expects to generate new understanding by combining relevant cell and animal models, protein chemistry, epi ....Augmenting the activity of glyoxalase-1 to increase dicarbonyl clearance . Reactive intermediates generated during our metabolism contribute to ageing. Glyoxalase-1 is a key defence enzyme against these toxic intermediates and therefore ageing itself. This project aims to investigate novel pathways how the expression and activity of glyoxalase-1 are regulated. This interdisciplinary project expects to generate new understanding by combining relevant cell and animal models, protein chemistry, epigenetics and structural biology. It is expected that this work will improve understanding of this fundamental biological defence. This will allow us to identify the potential means to enhance the capacity of glyoxalase-1 to the future benefit of biological ageing.Read moreRead less
Signaling in the crypt: a novel metabolic pathway in intestinal stem cells. The gut is the most rapidly renewing tissue in the body, driven by a highly active stem cell niche. Bile acids are emerging as critical regulators of this stem cell niche and disruption of bile acid homeostasis has profoundly adverse effects on intestinal renewal and hence gut health. We are addressing a critical gap in our understanding of how bile acids are controlled within stem cell niche. The aim of the project is ....Signaling in the crypt: a novel metabolic pathway in intestinal stem cells. The gut is the most rapidly renewing tissue in the body, driven by a highly active stem cell niche. Bile acids are emerging as critical regulators of this stem cell niche and disruption of bile acid homeostasis has profoundly adverse effects on intestinal renewal and hence gut health. We are addressing a critical gap in our understanding of how bile acids are controlled within stem cell niche. The aim of the project is to define the critical role of a novel enzyme called UGT8 in controlling intestinal stem cell response to bile acids; this is achieved by modulating UGT8 activity in intestinal stem cell models and determining the effects on stem cell function and the key signalling pathways that control intestinal homeostasis and renewal.Read moreRead less
Unravelling the complexities of cell death pathways . This project aims to test if cells can flexibly rewire their cell death pathways to ensure that the absence or inhibition of one type of cell death can be compensated through the triggering of another. The project expects to generate new knowledge in the area of programed cell death, and more specifically will address why cells have multiple programmed ways to die. Expected outcomes of this project include the provision of unprecedented insig ....Unravelling the complexities of cell death pathways . This project aims to test if cells can flexibly rewire their cell death pathways to ensure that the absence or inhibition of one type of cell death can be compensated through the triggering of another. The project expects to generate new knowledge in the area of programed cell death, and more specifically will address why cells have multiple programmed ways to die. Expected outcomes of this project include the provision of unprecedented insights into the molecular regulation of how cells orchestrate and integrate cell death pathways. This should provide significant benefits, such as providing the knowledge base needed to improve our abilities to manipulate cell death both in basic research and commercial applications of cell death.Read moreRead less
EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cel ....EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cell survival. This project advances basic and applied biology. Its outcomes will be relevant to several research areas and industries, specifically to the propagation of cell cultures that nowadays contributes to the production of a myriad of biotechnical and pharmaceutical commodities.
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Sodium-Metal-Free, Safe and Sustainable Sodium-Ion Sulfur Batteries. This project aims to develop sodium sulfide cathodes via effective single-atom catalysts and elaborately regulate the solid-electrolyte interphase on the anode by using a new class of electrolytes. Thus, the obtained low-cost, high-energy, safe sodium-ion sulfur batteries can serve as a novel technique for large-scale stationary energy storage, especially for intermittent solar and wind energy storage in Australia. Expected out ....Sodium-Metal-Free, Safe and Sustainable Sodium-Ion Sulfur Batteries. This project aims to develop sodium sulfide cathodes via effective single-atom catalysts and elaborately regulate the solid-electrolyte interphase on the anode by using a new class of electrolytes. Thus, the obtained low-cost, high-energy, safe sodium-ion sulfur batteries can serve as a novel technique for large-scale stationary energy storage, especially for intermittent solar and wind energy storage in Australia. Expected outcomes include a comprehensive understanding and a breakthrough in advances of innovative and affordable battery storage technology, leading to significant scientific, economic, environmental, and social benefits to Australia by integrating this battery system with renewable energy.Read moreRead less