Solar solutions to improve energy affordability for low-income renters. This Project aims to develop solutions for low-income renters to access solar energy. Low-income households spend higher proportions of income on electricity costs. Solar energy is a key way to reduce electricity costs and thus improve energy affordability. Renters are largely excluded from this opportunity. Intended Project outcomes are solutions to access solar energy suitable for widespread application to low-income priva ....Solar solutions to improve energy affordability for low-income renters. This Project aims to develop solutions for low-income renters to access solar energy. Low-income households spend higher proportions of income on electricity costs. Solar energy is a key way to reduce electricity costs and thus improve energy affordability. Renters are largely excluded from this opportunity. Intended Project outcomes are solutions to access solar energy suitable for widespread application to low-income private, public and community rental housing. Adoption of the Project’s outcomes are expected to benefit low-income renters, assist electricity retailers to maintain and extend their customer base, and provide commercial incentives for the many stakeholders providing rental housing and residential solar and battery systems.Read moreRead less
Unravelling the enigma of turbulence by integrating simulation & modelling. This project will transform how turbulence and flow-induced noise is understood and predicted to help meet the challenge of ever-growing transport and energy demands in an affordable and sustainable way. This will be achieved by integrating the latest simulation advances with unique machine-learning approaches. The expected outcome will be a paradigm shift in how turbulence and noise models are created and used, informed ....Unravelling the enigma of turbulence by integrating simulation & modelling. This project will transform how turbulence and flow-induced noise is understood and predicted to help meet the challenge of ever-growing transport and energy demands in an affordable and sustainable way. This will be achieved by integrating the latest simulation advances with unique machine-learning approaches. The expected outcome will be a paradigm shift in how turbulence and noise models are created and used, informed by new scientific knowledge and data. The proliferation of these new models will allow the design and operation of more efficient, reliable and quieter technologies in the aerospace, naval and energy industries, benefitting the Australian economy and environment, and raise the international profile of our scientists.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100429
Funder
Australian Research Council
Funding Amount
$406,177.00
Summary
Bioinspired Photocatalysts for Solar-Driven Hydrogen Peroxide Production. This project aims to develop advanced photocatalysts that can efficiently produce hydrogen peroxide from just water, air, and sunlight. By mimicking the structure and function of the natural photosynthetic apparatus, the key innovations are expected in the design of reaction-oriented conjugated polymer-based photocatalysts at the atomic and molecular nanostructure levels. It expects to generate new knowledge in artificial ....Bioinspired Photocatalysts for Solar-Driven Hydrogen Peroxide Production. This project aims to develop advanced photocatalysts that can efficiently produce hydrogen peroxide from just water, air, and sunlight. By mimicking the structure and function of the natural photosynthetic apparatus, the key innovations are expected in the design of reaction-oriented conjugated polymer-based photocatalysts at the atomic and molecular nanostructure levels. It expects to generate new knowledge in artificial photosynthesis and rational design of functional materials, and sustainable technology for hydrogen peroxide production. This cross-disciplinary research will benefit Australia by the development of biomimetic catalysts for advancing solar energy conversion and enabling sustainable manufacturing of commodity chemicals. Read moreRead less
Innovations in Green Chemical Manufacture from Synchrotron based Techniques. This project aims to find sustainable ways to produce commodity chemicals by developing new catalysts. New synchrotron techniques will be developed and applied to provide new knowledge about the spatial and temporal factors affecting the selectivity and efficiency of electron transfer, redox reactions and diffusion, key for catalyst design. Expected outcomes include the development of new catalysts, new catalyst design ....Innovations in Green Chemical Manufacture from Synchrotron based Techniques. This project aims to find sustainable ways to produce commodity chemicals by developing new catalysts. New synchrotron techniques will be developed and applied to provide new knowledge about the spatial and temporal factors affecting the selectivity and efficiency of electron transfer, redox reactions and diffusion, key for catalyst design. Expected outcomes include the development of new catalysts, new catalyst design concepts and a knowledge repository/database of analytical observations key for unlocking new materials knowledge. This should provide significant economic and environmental benefits by placing Australia at the forefront of the sustainable production of commodity chemicals.Read moreRead less
Augmenting the activity of glyoxalase-1 to increase dicarbonyl clearance . Reactive intermediates generated during our metabolism contribute to ageing. Glyoxalase-1 is a key defence enzyme against these toxic intermediates and therefore ageing itself. This project aims to investigate novel pathways how the expression and activity of glyoxalase-1 are regulated. This interdisciplinary project expects to generate new understanding by combining relevant cell and animal models, protein chemistry, epi ....Augmenting the activity of glyoxalase-1 to increase dicarbonyl clearance . Reactive intermediates generated during our metabolism contribute to ageing. Glyoxalase-1 is a key defence enzyme against these toxic intermediates and therefore ageing itself. This project aims to investigate novel pathways how the expression and activity of glyoxalase-1 are regulated. This interdisciplinary project expects to generate new understanding by combining relevant cell and animal models, protein chemistry, epigenetics and structural biology. It is expected that this work will improve understanding of this fundamental biological defence. This will allow us to identify the potential means to enhance the capacity of glyoxalase-1 to the future benefit of biological ageing.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100259
Funder
Australian Research Council
Funding Amount
$467,964.00
Summary
Interrogating the adaptive potential of skeletal muscle. Disruptions to muscle oxidative capacity and growth signalling underpin atrophy and dysfunction with ageing, which impacts on an individual’s quality of life. These biological processes are thought to be mutually exclusive and compete during muscle adaptation. This project aims to define how these processes regulate the extent of muscle adaptation, and how modifying these attributes influence functional capacity in the context of ageing. T ....Interrogating the adaptive potential of skeletal muscle. Disruptions to muscle oxidative capacity and growth signalling underpin atrophy and dysfunction with ageing, which impacts on an individual’s quality of life. These biological processes are thought to be mutually exclusive and compete during muscle adaptation. This project aims to define how these processes regulate the extent of muscle adaptation, and how modifying these attributes influence functional capacity in the context of ageing. This project will provide fundamental new knowledge in understanding how modifying muscle attributes influence successful ageing. This knowledge will improve resilience, productivity, and wellbeing of all Australians, with implications for reducing societal and economic burden.Read moreRead less
Unravelling the complexities of cell death pathways . This project aims to test if cells can flexibly rewire their cell death pathways to ensure that the absence or inhibition of one type of cell death can be compensated through the triggering of another. The project expects to generate new knowledge in the area of programed cell death, and more specifically will address why cells have multiple programmed ways to die. Expected outcomes of this project include the provision of unprecedented insig ....Unravelling the complexities of cell death pathways . This project aims to test if cells can flexibly rewire their cell death pathways to ensure that the absence or inhibition of one type of cell death can be compensated through the triggering of another. The project expects to generate new knowledge in the area of programed cell death, and more specifically will address why cells have multiple programmed ways to die. Expected outcomes of this project include the provision of unprecedented insights into the molecular regulation of how cells orchestrate and integrate cell death pathways. This should provide significant benefits, such as providing the knowledge base needed to improve our abilities to manipulate cell death both in basic research and commercial applications of cell death.Read moreRead less
EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cel ....EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cell survival. This project advances basic and applied biology. Its outcomes will be relevant to several research areas and industries, specifically to the propagation of cell cultures that nowadays contributes to the production of a myriad of biotechnical and pharmaceutical commodities.
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How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240101286
Funder
Australian Research Council
Funding Amount
$469,707.00
Summary
SARS-CoV-2-induced dead cell fragments drive viral uptake and inflammation. This project will apply advanced cell biology and imaging techniques to investigate how macrophages, which lacks a canonical receptor for viral entry, become infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and elicit inflammatory responses. Its insights into a novel pathway of viral entry is expected to advance our understanding of host-pathogen interaction. The project is intended to uncover t ....SARS-CoV-2-induced dead cell fragments drive viral uptake and inflammation. This project will apply advanced cell biology and imaging techniques to investigate how macrophages, which lacks a canonical receptor for viral entry, become infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and elicit inflammatory responses. Its insights into a novel pathway of viral entry is expected to advance our understanding of host-pathogen interaction. The project is intended to uncover the role of SARS-CoV-2-induced dead cell fragmentation in promoting viral uptake and inflammation. Its findings should provide significant scientific, health and economic benefits by informing new research directions on infection and innate immunity as well as future therapeutic designs for infection treatment.Read moreRead less