Subunit stoichiometry and arrangement in the glycine receptor. Glycine receptors are important for nervous system function. These receptors comprise a mixture of 5 alpha and beta subunits arranged around a central ion-conducting pore. The subunit stoichiometry (i.e., numbers of alpha and beta subunits) and arrangement (i.e., subunit order) are unknown. The first aim of this project is to define these parameters using tethered subunits. The second aim is to use the tethered subunits to probe th ....Subunit stoichiometry and arrangement in the glycine receptor. Glycine receptors are important for nervous system function. These receptors comprise a mixture of 5 alpha and beta subunits arranged around a central ion-conducting pore. The subunit stoichiometry (i.e., numbers of alpha and beta subunits) and arrangement (i.e., subunit order) are unknown. The first aim of this project is to define these parameters using tethered subunits. The second aim is to use the tethered subunits to probe the structure and function of glycine and zinc binding sites at an unprecedented level of resolution. The results will provide crucial new information concerning glycine receptor structure and function.Read moreRead less
Dissection of nodule and lateral root development in the model legume Lotus japonicus. We propose to isolate and decipher the function of plant genes involved in nodule development, with the view to extend and compare this knowledge to lateral root formation. While nodulation and lateral root formation are distinct processes, they appear to share anatomical and biochemical features. Working hypothesis is that nodule formation borrowed functions from lateral root development. Our approach impleme ....Dissection of nodule and lateral root development in the model legume Lotus japonicus. We propose to isolate and decipher the function of plant genes involved in nodule development, with the view to extend and compare this knowledge to lateral root formation. While nodulation and lateral root formation are distinct processes, they appear to share anatomical and biochemical features. Working hypothesis is that nodule formation borrowed functions from lateral root development. Our approach implements T-DNA and transposon insertional mutagenesis in the model legume Lotus japonicus. The success of this project will contribute significantly to the studies of plant-microbe interaction and plant morphogenesis.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668241
Funder
Australian Research Council
Funding Amount
$824,610.00
Summary
A Facility for High-Throughput, Functional Gene Discovery Using Arrayed Retroviral Expression Cloning. The proposed facility will represent world-leading technology in functional genomics and provide Australian scientists with unique opportunities to identify genes involved in a broad range of biological processes. This will contribute to fundamental knowledge in mammalian biology, and equally importantly, is likely to identify genes involved in important health problems such as cancer, inflamma ....A Facility for High-Throughput, Functional Gene Discovery Using Arrayed Retroviral Expression Cloning. The proposed facility will represent world-leading technology in functional genomics and provide Australian scientists with unique opportunities to identify genes involved in a broad range of biological processes. This will contribute to fundamental knowledge in mammalian biology, and equally importantly, is likely to identify genes involved in important health problems such as cancer, inflammatory disease, brain damage and diabetes. Such genes may in turn constitute targets against which new therapies may be developed. This endeavour will contribute to national research priorities in both the health and scientific/technological development arenas.Read moreRead less
NANO-SCALE CATALYST SYSTEMS FOR HYDROGEN GENERATION FOR FUEL CELLS. The project aims to develop nano-scale catalyst materials for micro-channel fuel processing systems. Micro-channel reactors have the benefits over conventional technology of being more compact and potential for much lower costs. This will assist in the development of hydrogen generation systems for fuel cells, as well as other chemical processing applications such as gas-to-liquids technology. The technology has the potential t ....NANO-SCALE CATALYST SYSTEMS FOR HYDROGEN GENERATION FOR FUEL CELLS. The project aims to develop nano-scale catalyst materials for micro-channel fuel processing systems. Micro-channel reactors have the benefits over conventional technology of being more compact and potential for much lower costs. This will assist in the development of hydrogen generation systems for fuel cells, as well as other chemical processing applications such as gas-to-liquids technology. The technology has the potential to generate significant IP in an evolving multi-billion dollar fuel cell industry. Support from Ceramic Fuel Cells Ltd. and the Gas Technology Institute will ensure that the work has an international as well as national perspective, and a route to exploitation.Read moreRead less
TAILORING OF CARBON MATERIALS FOR USE IN DIRECT CARBON FUEL CELLS. This project aims to develop a fundamental understanding of and methods for tailoring carbon materials to be used in high efficiency (80-85%) direct carbon fuel cells (DCFC). This project addresses an important area in clean and efficient energy supply to meet the World's long-term energy and environmental requirements. Specifically, we aim to focus on the carbon particulates based on carbon black materials with a turbostratic st ....TAILORING OF CARBON MATERIALS FOR USE IN DIRECT CARBON FUEL CELLS. This project aims to develop a fundamental understanding of and methods for tailoring carbon materials to be used in high efficiency (80-85%) direct carbon fuel cells (DCFC). This project addresses an important area in clean and efficient energy supply to meet the World's long-term energy and environmental requirements. Specifically, we aim to focus on the carbon particulates based on carbon black materials with a turbostratic structure, and to investigate the relationship between the microstructures of synthetic carbon black materials and their efficacy in DCFC systems. Ultimately, we aim to engineer novel carbon particulates for use in DCFCs.Read moreRead less
Hydrogen Production by Non-thermal Plasma Assisted Catalytic Pyrolysis of Natural Gas. This project aims to develop a cost effective technology for hydrogen production using catalytic pyrolysis of natural gas assisted by non-thermal plasma. The mechanism and kinetics of catalytic hydrocarbon decomposition on carbons produced in situ will be systematically studied. Based on the fundamental understanding of carbon nanostructures and their catalytic activities and stabilities, the non-thermal plasm ....Hydrogen Production by Non-thermal Plasma Assisted Catalytic Pyrolysis of Natural Gas. This project aims to develop a cost effective technology for hydrogen production using catalytic pyrolysis of natural gas assisted by non-thermal plasma. The mechanism and kinetics of catalytic hydrocarbon decomposition on carbons produced in situ will be systematically studied. Based on the fundamental understanding of carbon nanostructures and their catalytic activities and stabilities, the non-thermal plasma and the catalytic reactions will be optimized to achieve high conversion and catalytic stability. The project will lead to a new process combining effective carbon catalyst and low temperature plasma to produce pure hydrogen with high energy efficiency and no CO2 emissions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0236372
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
CENTRIFUGATION FACILITIES FOR THE GENETICS ANALYSIS FACILITY. Access to both a high-speed centrifuge and an ultracentrifuge is essential for a wide range of biochemistry and molecular biology research projects. A high-speed centrifuge is essential for the collection of bacteria cultured to express specific proteins as well as the collection of purified proteins isolated from a wide range of organisms. Similarly an ultracentrifuge is required for the isolation of viruses and the preparation and p ....CENTRIFUGATION FACILITIES FOR THE GENETICS ANALYSIS FACILITY. Access to both a high-speed centrifuge and an ultracentrifuge is essential for a wide range of biochemistry and molecular biology research projects. A high-speed centrifuge is essential for the collection of bacteria cultured to express specific proteins as well as the collection of purified proteins isolated from a wide range of organisms. Similarly an ultracentrifuge is required for the isolation of viruses and the preparation and purification of RNA and DNA. The two machines will facilitate the continuation of research projects funded by both government and industry grants. The centrifuges will complement the equipment available in the Genetic Analysis Facility.Read moreRead less
Engineered functional metal silica membranes for hydrogen processing. This project focuses on hydrogen processing technologies for the petrochemical, agricultural and coal/energy industries. These sectors employ 110,000 people with annual combined revenues of $80 billion. Advanced technologies are vital for the competitiveness of the Australian economy, and to sustain Australia's social stability and economic growth.
Development of Superflux Carbon Nanotube Membranes for Gas Separation. The project seeks to develop gas separation membranes displaying superfluxes - throughputs 10 to 100 times higher than current systems, with lower operating costs. There is compelling evidence that very high flow rates are achievable and they have been shown for single gas transport. Theory predicts that highly selective separations are possible, but this has not yet been experimentally shown - a key outcome from this proje ....Development of Superflux Carbon Nanotube Membranes for Gas Separation. The project seeks to develop gas separation membranes displaying superfluxes - throughputs 10 to 100 times higher than current systems, with lower operating costs. There is compelling evidence that very high flow rates are achievable and they have been shown for single gas transport. Theory predicts that highly selective separations are possible, but this has not yet been experimentally shown - a key outcome from this project. The applications are widespread and include separation of carbon dioxide from power station flue gas for sequestration, purification of natural gas and provision of pure component gases such as oxygen and nitrogen amongst others.Read moreRead less
Conantokin selectivity for heteromeric N-methyl-D-aspartate (NMDA) receptors. NMDA receptors are ligand gated ion channels formed by heterogeneous population of subunits with distinct pharmacological and biophysical properties. The heterogeneic receptors are differentially expressed during development and play an important role in many physiological and pathological processes. Conantokins are toxins isolated from Conus venoms, which target NMDA receptor subunits with high affinity. The primary g ....Conantokin selectivity for heteromeric N-methyl-D-aspartate (NMDA) receptors. NMDA receptors are ligand gated ion channels formed by heterogeneous population of subunits with distinct pharmacological and biophysical properties. The heterogeneic receptors are differentially expressed during development and play an important role in many physiological and pathological processes. Conantokins are toxins isolated from Conus venoms, which target NMDA receptor subunits with high affinity. The primary goal of this study is to examine the effects of conantokins on the molecular properties of different NMDA receptor subtypes in vivo and in vitro.Read moreRead less