Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668241
Funder
Australian Research Council
Funding Amount
$824,610.00
Summary
A Facility for High-Throughput, Functional Gene Discovery Using Arrayed Retroviral Expression Cloning. The proposed facility will represent world-leading technology in functional genomics and provide Australian scientists with unique opportunities to identify genes involved in a broad range of biological processes. This will contribute to fundamental knowledge in mammalian biology, and equally importantly, is likely to identify genes involved in important health problems such as cancer, inflamma ....A Facility for High-Throughput, Functional Gene Discovery Using Arrayed Retroviral Expression Cloning. The proposed facility will represent world-leading technology in functional genomics and provide Australian scientists with unique opportunities to identify genes involved in a broad range of biological processes. This will contribute to fundamental knowledge in mammalian biology, and equally importantly, is likely to identify genes involved in important health problems such as cancer, inflammatory disease, brain damage and diabetes. Such genes may in turn constitute targets against which new therapies may be developed. This endeavour will contribute to national research priorities in both the health and scientific/technological development arenas.Read moreRead less
Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not re ....Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not respond to the current TNF treatments. Improved anti-TNF strategies would provide enhanced health outcomes and welcome relief to many Australians. In addition, the economic benefit of the TNF market is very substantial. Therefore the potential impact of this research is very high both for health care and economical potential.Read moreRead less
Unravelling the enigma of turbulence by integrating simulation & modelling. This project will transform how turbulence and flow-induced noise is understood and predicted to help meet the challenge of ever-growing transport and energy demands in an affordable and sustainable way. This will be achieved by integrating the latest simulation advances with unique machine-learning approaches. The expected outcome will be a paradigm shift in how turbulence and noise models are created and used, informed ....Unravelling the enigma of turbulence by integrating simulation & modelling. This project will transform how turbulence and flow-induced noise is understood and predicted to help meet the challenge of ever-growing transport and energy demands in an affordable and sustainable way. This will be achieved by integrating the latest simulation advances with unique machine-learning approaches. The expected outcome will be a paradigm shift in how turbulence and noise models are created and used, informed by new scientific knowledge and data. The proliferation of these new models will allow the design and operation of more efficient, reliable and quieter technologies in the aerospace, naval and energy industries, benefitting the Australian economy and environment, and raise the international profile of our scientists.Read moreRead less
Unravelling the sub-nuclear complexity of the brain. Understanding the function of the brain is a major frontier of scientific research. The ability to increase knowledge of brain function is reliant upon the development of novel methods. This application will develop a novel approach for understanding the function of particular nerve cells. One outcome will be demonstration of the applicability of a novel method of benefit to all brain researchers. Another outcome will be increased understandin ....Unravelling the sub-nuclear complexity of the brain. Understanding the function of the brain is a major frontier of scientific research. The ability to increase knowledge of brain function is reliant upon the development of novel methods. This application will develop a novel approach for understanding the function of particular nerve cells. One outcome will be demonstration of the applicability of a novel method of benefit to all brain researchers. Another outcome will be increased understanding of one brain region that is known to contribute to the development of cardiovascular disease. It is expected that increased knowledge of brain function will lead to novel theories of brain disease and therapeutic strategies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100429
Funder
Australian Research Council
Funding Amount
$406,177.00
Summary
Bioinspired Photocatalysts for Solar-Driven Hydrogen Peroxide Production. This project aims to develop advanced photocatalysts that can efficiently produce hydrogen peroxide from just water, air, and sunlight. By mimicking the structure and function of the natural photosynthetic apparatus, the key innovations are expected in the design of reaction-oriented conjugated polymer-based photocatalysts at the atomic and molecular nanostructure levels. It expects to generate new knowledge in artificial ....Bioinspired Photocatalysts for Solar-Driven Hydrogen Peroxide Production. This project aims to develop advanced photocatalysts that can efficiently produce hydrogen peroxide from just water, air, and sunlight. By mimicking the structure and function of the natural photosynthetic apparatus, the key innovations are expected in the design of reaction-oriented conjugated polymer-based photocatalysts at the atomic and molecular nanostructure levels. It expects to generate new knowledge in artificial photosynthesis and rational design of functional materials, and sustainable technology for hydrogen peroxide production. This cross-disciplinary research will benefit Australia by the development of biomimetic catalysts for advancing solar energy conversion and enabling sustainable manufacturing of commodity chemicals. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668513
Funder
Australian Research Council
Funding Amount
$280,000.00
Summary
Time of Flight Aerosol Mass Spectrometer for Research on Airborne Particles and their impact on Health and the Environment. No TOF-AMS is currently available in Australia and thus, if acquired, it would significantly enhance Australian research capabilities in a field of high importance for the country and internationally, which is the nature and chemical composition of atmospheric aerosols, their origins and dynamics. The proposed studies with the application of this instrument would greatly in ....Time of Flight Aerosol Mass Spectrometer for Research on Airborne Particles and their impact on Health and the Environment. No TOF-AMS is currently available in Australia and thus, if acquired, it would significantly enhance Australian research capabilities in a field of high importance for the country and internationally, which is the nature and chemical composition of atmospheric aerosols, their origins and dynamics. The proposed studies with the application of this instrument would greatly increase scientific knowledge of atmospheric particles; would contribute to general welfare and economy in terms of enabling qualitative risk assessment of airborne particles on humans and the environment, and in turn, risk prevention. It would also enable the University partners to continue to produce graduates of high quality, conversant with cutting edge science.Read moreRead less
ARC Centre for Functional Nanomaterials. The Centre will consist of leading researchers from four Australian universities, four CSIRO divisions, and two US research centres. The vision is to position Australia as a world leader in nanomaterials science and technology. The Centre will involve nanoscale science for building functional nanostructures of materials at the molecular level. It aims to develop new methods and techniques for self-assembling and characterizing nanomaterials with tailorabl ....ARC Centre for Functional Nanomaterials. The Centre will consist of leading researchers from four Australian universities, four CSIRO divisions, and two US research centres. The vision is to position Australia as a world leader in nanomaterials science and technology. The Centre will involve nanoscale science for building functional nanostructures of materials at the molecular level. It aims to develop new methods and techniques for self-assembling and characterizing nanomaterials with tailorable properties. The outcomes will include leading-edge science, the development of human capital, and intellectual property in new materials and products for applications in clean energy, environmental, and health care industries.Read moreRead less
Towards the development of a novel live vaccine for the control of Glässer's disease (Haemophilus parasuis), a globally significant respiratory disease of swine. Respiratory diseases are common in intensively housed pigs, costing the Australian industry millions of dollars in lost production annually. Glässer's is a highly contagious and often fatal respiratory disease of pigs. Antibiotic therapy is expensive and often results in the emergence of antibiotic resistant organisms. There is also a t ....Towards the development of a novel live vaccine for the control of Glässer's disease (Haemophilus parasuis), a globally significant respiratory disease of swine. Respiratory diseases are common in intensively housed pigs, costing the Australian industry millions of dollars in lost production annually. Glässer's is a highly contagious and often fatal respiratory disease of pigs. Antibiotic therapy is expensive and often results in the emergence of antibiotic resistant organisms. There is also a trend to move away from the use of antibiotics in food production animals. Current vaccines are based on inactivated preparations and do not offer a high level of immune protection. Therefore, there is a great need worldwide for a live vaccine for the effective control of Glässer's disease.Read moreRead less
Devising a legal blueprint for corporate energy transition. This project aims to provide a legal blueprint for using corporate law mechanisms to incentivise improved climate risk management and clean energy practices in Australian companies. Corporations are key players in efforts to transition the global energy system to clean energy sources and to mitigate climate risk. While this role is widely acknowledged, thinking on the best legal strategies that could foster corporate energy transition i ....Devising a legal blueprint for corporate energy transition. This project aims to provide a legal blueprint for using corporate law mechanisms to incentivise improved climate risk management and clean energy practices in Australian companies. Corporations are key players in efforts to transition the global energy system to clean energy sources and to mitigate climate risk. While this role is widely acknowledged, thinking on the best legal strategies that could foster corporate energy transition is in its infancy. Drawing on empirical data and more extensive United States experience with the use of corporate law tools for climate ends, the project plans to uncover roadblocks to corporate energy transformation, and identify law and governance reforms necessary for putting the private sector on a low-carbon pathway.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989487
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
The National Hydrogen Materials Reference Facility. Hydrogen energy technology is a vital element in the global response to climate change owing to increasing atmospheric carbon dioxide levels from burning fossil fuels. Hydrogen is a universal energy carrier that facilitates the transformation of energy from renewable and other sources for applications in industry, transport and homes. The National Hydrogen Materials Reference Facility is a multidisciplinary, state-of-the-art experimental facili ....The National Hydrogen Materials Reference Facility. Hydrogen energy technology is a vital element in the global response to climate change owing to increasing atmospheric carbon dioxide levels from burning fossil fuels. Hydrogen is a universal energy carrier that facilitates the transformation of energy from renewable and other sources for applications in industry, transport and homes. The National Hydrogen Materials Reference Facility is a multidisciplinary, state-of-the-art experimental facility for materials science supporting excellent research into advanced materials for hydrogen generation from fossil fuels and by solar means, hydrogen storage for automotive and stationary applications, hydrogen distribution and hydrogen end use, particularly in fuel cells that generate electricity.Read moreRead less