The nature, extent and effect of infant removal by child protection. This project aims to provide new knowledge about the nature, extent and effect of removals of babies from their parents in Australia. Removal is the highest level of intervention by the child protection system, and one which some mothers experienced on multiple occasions. Little is known, however, about its incidence and effects, nor whether there are over-represented groups (e.g. Aboriginal mothers and babies) who would respon ....The nature, extent and effect of infant removal by child protection. This project aims to provide new knowledge about the nature, extent and effect of removals of babies from their parents in Australia. Removal is the highest level of intervention by the child protection system, and one which some mothers experienced on multiple occasions. Little is known, however, about its incidence and effects, nor whether there are over-represented groups (e.g. Aboriginal mothers and babies) who would respond to targeted interventions. This project aims to identify appropriate early intervention and prevention strategies, preventing the need for babies to spend their whole childhood in care at great financial and societal cost.Read moreRead less
CX3C chemokine signalling in the olfactory epithelium and its role in the self regeneration of the olfactory system. The current proposal will explore new venues in adult neural stem cell research and contribute to the further development of molecular biology and neuroscience research in Western Australia and Australia. The use of neural stem cells holds therapeutic promise for the treatment of a wide variety of neurological conditions, including neurotrauma and stroke. The proposed research wil ....CX3C chemokine signalling in the olfactory epithelium and its role in the self regeneration of the olfactory system. The current proposal will explore new venues in adult neural stem cell research and contribute to the further development of molecular biology and neuroscience research in Western Australia and Australia. The use of neural stem cells holds therapeutic promise for the treatment of a wide variety of neurological conditions, including neurotrauma and stroke. The proposed research will provide new data on the fundamental cellular and molecular events that are required to trigger the birth, differentiation and conditions for growth of new neurons in the adult nervous system. The generation of such insights will be critical for any translational research.
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Vulnerable families: A study of the impact of parental offending and incarceration on children's developmental outcomes. The limited evidence available suggests that parental incarceration severely compromises the development and well-being of children and increases the risk of delinquency. The financial and personal costs to the community of individuals embarking on an offending career are substantial. Significant cost-savings and prevention of victimisation could result from effectively target ....Vulnerable families: A study of the impact of parental offending and incarceration on children's developmental outcomes. The limited evidence available suggests that parental incarceration severely compromises the development and well-being of children and increases the risk of delinquency. The financial and personal costs to the community of individuals embarking on an offending career are substantial. Significant cost-savings and prevention of victimisation could result from effectively targeting this high-risk population. This research will identify where and when scarce government resources should be targeted. Appropriately timed programs can deliver a range of long-term benefits for children, families and communities. The research will also investigate the reintegration of prisoners into their families, with the aim of reducing prisoner recidivism.Read moreRead less
Alcohol’s harm to others: patterns, costs, disparities and precipitants. This project aims to generate understanding of the magnitude, character, economic burden, disparities and precipitants of occurrence of alcohol’s harm to others across Australia, using a national survey, crime, community services and health data and qualitative interviews. The project outcome will be a robust current evidence base for our partners, government and Australian society to underpin advocacy, policy and planning, ....Alcohol’s harm to others: patterns, costs, disparities and precipitants. This project aims to generate understanding of the magnitude, character, economic burden, disparities and precipitants of occurrence of alcohol’s harm to others across Australia, using a national survey, crime, community services and health data and qualitative interviews. The project outcome will be a robust current evidence base for our partners, government and Australian society to underpin advocacy, policy and planning, aimed at reducing alcohol-related harm and suffering.Read moreRead less
Exploring Wellbeing Outcomes in the Aquatic and Recreation Industry. This project aims to investigate the impact on individual wellbeing through use of public aquatic and recreation centres in Australia. Through the use of mixed methods across multiple locations, the project expects to generate new knowledge on the effect on users of different management and service models for the provision of aquatic and recreational infrastructure. Expected outcomes include a quantifiable measure of social and ....Exploring Wellbeing Outcomes in the Aquatic and Recreation Industry. This project aims to investigate the impact on individual wellbeing through use of public aquatic and recreation centres in Australia. Through the use of mixed methods across multiple locations, the project expects to generate new knowledge on the effect on users of different management and service models for the provision of aquatic and recreational infrastructure. Expected outcomes include a quantifiable measure of social and emotional wellbeing that can be utilised by centre management and government. This will help assessment of best practice for maximising community wellbeing, and can guide investment decisions by state and local government.Read moreRead less
Defining the Brassica pan-genome and establishing methods for gene conversion based crop improvement. Gene content varies between individual varieties. The project aims to apply novel genomic tools to identify and characterise the fixed and variable gene content in the important crop canola and use this to understand genome evolution as well as develop tools to accelerate canola breeding. The project team have developed and used a high-resolution genotyping approach to demonstrate that gene conv ....Defining the Brassica pan-genome and establishing methods for gene conversion based crop improvement. Gene content varies between individual varieties. The project aims to apply novel genomic tools to identify and characterise the fixed and variable gene content in the important crop canola and use this to understand genome evolution as well as develop tools to accelerate canola breeding. The project team have developed and used a high-resolution genotyping approach to demonstrate that gene conversions, short recombination events which lead to the non-reciprocal exchange of genomic regions during meiosis, are abundant in crop genomes. The project aims to develop methods and resources to characterise gene conversion in canola and establish a basis for gene conversion based crop improvement.Read moreRead less
Cellular Cross-talk Between Liver Progenitor Cells And Hepatic Stellate Cells Is Required For Hepatic Fibrogenesis
Funder
National Health and Medical Research Council
Funding Amount
$618,517.00
Summary
Deloitte Access Economics data proposes the total economic burden of liver disease in Australia in 2012 was >$50 billion. This study will identify how the liver heals itself by inducing liver cell populations which interact to regenerate damaged liver tissue in chronic liver disease. This knowledge may lead to the development of novel therapeutic interventions for the treatment of liver scarring and liver cancer, and to assist in normal liver regeneration following chronic liver disease.
Investigating the molecular basis of T-cell receptor cross-reactivity. This project will explore the basis of unexpected immune reactions whereby the immune system mistakes one molecular structure for another, a phenomenon known as cross-reactivity. This project will examine how often this is due to molecular mimicry, potentially explaining why immune T cells sometimes react inappropriately to different agents.
ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory ne ....ARC/NHMRC Research Network in Genes and Environment in Development. Interactions between the early environment and the genetic regulatory program of the developing organism have major consequences for the lifetime health of individuals. The primary objective of the Network in Genes and Environment in Development is to harness the resources of leading researchers from the currently distinct disciplines of developmental biology and developmental physiology to define key developmental regulatory networks and to address how environmental factors impinge on these regulatory networks. The formation of this National Research Network is unique, timely and strategic. It will generate new insights into the mechanisms by which events in early life determine the risk of adverse outcomes in perinatal and adult life.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less