Genetic architecture of species divergence and hybridisation in eucalypts. Eucalypts are an icon of Australia and are of great economic and ecological significance to the nation. They are the most widely planted hardwood trees in the world, but Australia is the centre of origin of most species and the custodian of this important native bioresource. Understanding the evolutionary processes that shape diversity in this internationally significant genus is important for its long-term management a ....Genetic architecture of species divergence and hybridisation in eucalypts. Eucalypts are an icon of Australia and are of great economic and ecological significance to the nation. They are the most widely planted hardwood trees in the world, but Australia is the centre of origin of most species and the custodian of this important native bioresource. Understanding the evolutionary processes that shape diversity in this internationally significant genus is important for its long-term management and conservation. This project links to large international initiatives currently underway for high-density mapping and sequencing of the eucalypt genome, to enhance the flow of information gained back to Australia for scientific, economic and environmental benefit.Read moreRead less
Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge mic ....Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge microscopy techniques to visualise whether the endogenous astrocyte protein metallothionein can promote regeneration in the injured nervous system of living zebrafish. The successful outcomes of this project will provide significant insight into understanding how the brain responds to injury.Read moreRead less
Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-th ....Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-thalassaemia, understanding the specific aHb-binding factor, AHSP is a goal of national significance. In the long term, manipulation of AHSP function through gene therapy may have a direct role in the treatment of thalassaemia.Read moreRead less
Contribution of hybridisation to genetic diversity and adaptation in Eucalyptus. The eucalypt gene pool is an outstandingly important bioresource for Australia. Its effective future management will be based on understanding the extent, causes and significance of genetic variation in eucalypt species. This project investigates a currently overlooked, but potentially important, source of genetic diversity and adaptation in Eucalyptus. The knowledge gained will contribute substantially to our un ....Contribution of hybridisation to genetic diversity and adaptation in Eucalyptus. The eucalypt gene pool is an outstandingly important bioresource for Australia. Its effective future management will be based on understanding the extent, causes and significance of genetic variation in eucalypt species. This project investigates a currently overlooked, but potentially important, source of genetic diversity and adaptation in Eucalyptus. The knowledge gained will contribute substantially to our understanding of eucalypt biology, and will inform decision-making for conservation, revegetation, and sustainable use of seed resources. Through addressing fundamental questions, the project will also provide a uniquely Australian contribution to world research in forest molecular genetics.Read moreRead less
Rebuilding fiscal federalism in Australia: reforming the financial relationship between the Commonwealth and the States. The finances of the Australian States in the modern day face serious structural challenges. The aim of this project is to analyse and develop appropriate alternatives for reform of fiscal federalism in Australia, which would allow the States to gain access to income tax revenue as a secure source of funding in the future.
Using metallothioneins as a model for understanding cellular and biochemical interactions between neurons and astrocytes within the brain. This research will reveal some of the changes that occur in the relationship between neurons and astrocytes as a consequence injury, aging or disease to the human brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or in neurodegenerative diseases. These a ....Using metallothioneins as a model for understanding cellular and biochemical interactions between neurons and astrocytes within the brain. This research will reveal some of the changes that occur in the relationship between neurons and astrocytes as a consequence injury, aging or disease to the human brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or in neurodegenerative diseases. These are significant community issues in both economical and social terms. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest cellular processes associated with aging or disease of the brain, and will provide clues to promoting healthy aging.Read moreRead less
Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to th ....Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or neurodegenerative disease. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest biochemical and cellular processes associated with aging or disease of the brain.Read moreRead less
Genetic discrimination in Australia: an exploration of the nature and extent of the phenomenon within the legal and social context. This project involves national, groundbreaking research into the newly-emerging phenomenon of genetic discrimination in Australia. Undertaken by a multi-disciplinary, cross-institutional team with a wide range of expertise, this innovative and topical research will investigate genetic discrimination across three key perspectives: consumers, third parties and the le ....Genetic discrimination in Australia: an exploration of the nature and extent of the phenomenon within the legal and social context. This project involves national, groundbreaking research into the newly-emerging phenomenon of genetic discrimination in Australia. Undertaken by a multi-disciplinary, cross-institutional team with a wide range of expertise, this innovative and topical research will investigate genetic discrimination across three key perspectives: consumers, third parties and the legal system. It will advance the existing knowledge base, both nationally and internationally, and establish comprehensive baseline data for further evaluative research. Important outcomes for each of the three sectors will be generated, as well as a comprehensive overview of this important new Australian social issue. Recommendations will inform the development of appropriate law and policy.
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Revealing Enigma of Salt Bladders to Help Crops Cope with Salinity. In this project, the key transport systems mediating salt sequestration in halophytes are planned to be characterised and linked with cell genetic and metabolic profiles. Salinity is a major environmental hurdle affecting crop production around the world. Halophytes (naturally salt-loving plants) use specialised structures, called salt bladders, to sequester excessive salt outside their metabolically active parts. This feature i ....Revealing Enigma of Salt Bladders to Help Crops Cope with Salinity. In this project, the key transport systems mediating salt sequestration in halophytes are planned to be characterised and linked with cell genetic and metabolic profiles. Salinity is a major environmental hurdle affecting crop production around the world. Halophytes (naturally salt-loving plants) use specialised structures, called salt bladders, to sequester excessive salt outside their metabolically active parts. This feature is not utilised by crops however, and no information is available about the molecular mechanisms by which salt is pumped into bladder cells. This knowledge will allow breeders to utilise this, previously unexplored, trait to improve crop performance under conditions of salinity.Read moreRead less
Stomata functioning in halophytes for improved plant stress tolerance. This project aims to determine how halophytes balance photosynthesis and water loss under extreme soil conditions. Salinity and drought affect crop production. Plants’ ability to balance carbon dioxide uptake and water loss through stomata determines how they cope with stressors. Halophytes can achieve this balance at conditions that normally kill 99% of crops, but how they do so is unknown. This project will characterise the ....Stomata functioning in halophytes for improved plant stress tolerance. This project aims to determine how halophytes balance photosynthesis and water loss under extreme soil conditions. Salinity and drought affect crop production. Plants’ ability to balance carbon dioxide uptake and water loss through stomata determines how they cope with stressors. Halophytes can achieve this balance at conditions that normally kill 99% of crops, but how they do so is unknown. This project will characterise the transport systems mediating stomata function in halophytes and contribute to understanding the molecular and physiological basis of their operation. This should allow breeders to use this trait to improve crop performance under conditions of extreme salinity and drought.Read moreRead less